Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient's satisfaction with treatment

Perimenis, Petros; Karkoulias, Kiriakos; Konstantinopoulos, Angelis; Perimeni, Paraskevi P.; Katsenis, G.; Athanasopoulos, Anastasios; Spyropoulos, Konstantinos

doi:10.1111/j.1745-7262.2007.00085.x

Cited by 34 publications

(44 citation statements)

References 19 publications

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“…In another study, sildenafil increased CPAP effectiveness in patients with mild OSAS when compared with CPAP alone. 6 In contrast, in study by Margel et al, 28 CPAP treatment deteriorated erectile function. This may be due to the improper use of CPAP.…”

Section: Discussionmentioning

confidence: 91%

“…Consequently, without defining the cause of ED, many drugs such as sildenafil are used for treatment. 13 The use of sildenafil with CPAP was reported by Perimenis et al, 6 whereas Margel et al 28 reported the long-term effects of CPAP treatment on ED in patients with OSAS. The latter study showed that only 20% of patients with OSAS might show improved erectile function solely with CPAP treatment.…”

Section: Discussionmentioning

confidence: 99%

“…5 ED is characterized by the National Institutes of Health as the persistent or recurrent inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse. 6 Erection is an event that involves the integration of psychological, neurological, endocrinological and vascular systems. Any reduction in this cooperation may cause ED.…”

Section: Introductionmentioning

confidence: 99%

“…The effect of CPAP on ED has also been studied, with limited efficiency. 11 Perimenis et al 6 studied CPAP alone and CPAP with sildenafil in patients with OSAS with ED and found that sildenafil in combination with CPAP appears clearly superior to CPAP alone.…”

Section: Introductionmentioning

confidence: 99%

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Erectile dysfunction in severe sleep apnea patients and response to CPAP

Taşkın¹,

Yiğit²,

Acıoğlu³

et al. 2009

Int J Impot Res

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The aim of this study was to investigate frequency and degree of ED in patients with severe sleep apnea and to evaluate the results of only continuous positive airway pressure (CPAP) therapy on ED in patients with severe obstructive sleep apnea syndrome (OSAS). This was a prospective clinical trial study. Patients with severe sleep apnea (40) were randomized into two groups. Multiple questionnaire investigation and laboratory evaluation were performed for ED, severity of OSAS and psychological status. Group 1 was treated with CPAP and group 2 was treated with only antidepressant medication for at least 1 month. Patients were evaluated after 1 month of therapy and compared with initial ones. Before CPAP, the International Index of Erectile Function (IIEF)-5 scores were significantly correlated only with body mass index (BMI; P ¼ 0.007) and not correlated significantly with Epworth Sleepiness Scale scores (P ¼ 0.286), lowest SaO 2 (P ¼ 0.182), Beck's Depression Inventory scores (P ¼ 0.302) and apnea/hypopnea index (P ¼ 0.279). After 1 month of regular CPAP usage, mean value of IIEF-5 score was 15.71 ± 5.12 before CPAP and were improved up to 19.06 ± 3.94, statistically significant. All subjects responded positively to the CPAP treatment and their erection status was improved positively. We have found a correlation between severe OSAS and ED. CPAP is effective in improvement of sexual performance of these patients.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Erectile dysfunction in severe sleep apnea patients and response to CPAP

Taşkın¹,

Yiğit²,

Acıoğlu³

et al. 2009

Int J Impot Res

View full text Add to dashboard Cite

show abstract

“…However, RCTs comparing the effect of CPAP to sildenafil showed that both improved erectile function but sildenafil was superior. 147,[149][150][151] There are no RCTs that assessed the impact of CPAP on erectile dysfunction in patients with T2D but one uncontrolled study showed that CPAP for 3 months had no effect on sexual function in 35 men with T2D.…”

Section: Impact Of Continuous Positive Airway Pressurementioning

confidence: 99%

Obstructive Sleep Apnoea and Vascular Disease in Patients with Type 2 Diabetes

Tahrani¹

2015

US Endocrinology

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Obstructive sleep apnoea (OSA) is common and is associated with many vascular risk factors, such as hypertension, insulin resistance, albuminuria, dyslipidaemia, increased inflammation and endothelial dysfunction. Epidemiological studies have shown that OSA is associated with increased cardiovascular disease (CVD) and that continuous positive airway pressure (CPAP) might reduce CVD events in patients with OSA. In addition, OSA has also been shown to be associated with albuminuria, chronic kidney disease, a wide range of ocular diseases and peripheral neuropathy. Considering that CVD and microvascular complications are major contributors to the morbidity, mortality and the economic burden of diabetes and that OSA is common in patients with type 2 diabetes (T2D), it is important to understand the role of OSA in the development and/or progression of vascular disease in patients with T2D and to explore the impact of CPAP on diabetes-related vascular outcomes. The purpose of this article is to review the evidence for the relationship and impact of OSA on vascular disease and vascular risk factors particularly in patients with T2D. KeywordsType 2 diabetes, obstructive sleep apnoea, vascular disease, vascular risk Diabetes-related macro-and microvascular complications contribute significantly to the increased morbidity, mortality, worsened quality of life and social and financial burden observed in patients with diabetes. [1][2][3][4][5] Hence, reducing the development and/or the progression of these complications is one of the main aims of treatment in patients with diabetes.Over the last 2 decades, strategies resulting in the improvements of glycaemic control, blood pressure (BP) and lipids and the use of renin angiotensin aldosterone inhibitors, resulted in reductions in cardiovascular disease (CVD) in patients with diabetes, but there was little impact on diabetic microvascular complications. 6 Nonetheless, both CVD and microvascular complications remain common and a better understanding of the pathogenesis of these complications is needed in order to identify new treatment strategies.Obstructive sleep apnoea (OSA) is common in patients with type 2 diabetes (T2D) (up to 86 % prevalence), which is not surprising considering that increasing age and obesity are common risk factors to both conditions. 7,8 OSA is characterised by upper airway instability during sleep that results in recurrent upper airway obstruction resulting in either complete or partial cessation of airflow (i.e. apnoea and hypopnoea, respectively). 9The recurrent obstructions of the upper airway usually result in recurrent oxygen desaturations/re-saturations, cyclical changes in intrathoracic pressure (as the patient attempts to breath against a blocked airway) and recurrent micro arousals that cause sleep fragmentation and reduction in slow wave and rapid eye movement (REM) sleep and result in termination of the apnoea/hypopnoea episodes. 9Several large epidemiological studies and randomised controlled trials (RCTs) have shown that OSA was ...

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