“…On the other hand, Budtz-Jorgensen and Isidor (1987) did not indicate and specify how the analysis was completed, but all pre-specified outcomes were reported, and the number of losses to follow-up was small, thus it was judged as having a low risk of bias 33,34,37 . In the Budtz-Jorgensen and Isidor (1987) and Witter et al (2001) studies all outcomes were reported but outcomes were not prespecified as primary or secondary outcomes 33,34,37,[55][56][57] Both these studies were thus judged as having a high risk of bias. The three remaining RCTs specified the outcomes as primary and secondary and reported these as such, thus these were judged as having a low risk of bias [39][40][41][42][46][47][48][50][51][52][53][54] .…”