Significant Temporal Evolution of Diffusion Anisotropy for Evaluating Early Response to Radiosurgery in Patients with Vestibular Schwannoma: Findings from Functional Diffusion Maps

Lin, Yu; Wang, Chi‐Chih; Wai, Yau‐Yau; Wan, Yung Liang; Sh, Ng; Chen, Y. L.; Liu, Ho-Ling Anthony; Wang, Jiun‐Jie

doi:10.3174/ajnr.a1799

Cited by 19 publications

(9 citation statements)

References 24 publications

(34 reference statements)

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“…ADC values may be affected in tissue damage such as edema, degeneration, and necrosis [21]. Radiation-induced changes in the auditory pathways can be detected in patients with VS treated with radiosurgery [6,8,9,22]. In our study, contralateral LL FA values were lower than ipsilateral in the pretreatment period.…”

Section: Discussionmentioning

confidence: 44%

“…There was no strong correlation between them. A decrease in FA values may be associated with alterations in cytoarchitecture [22]. The weak relationship between the brainstem radiation dose and the slight decrease in contralateral HG FA values may indicate that no significant permanent damage to the radiation-induced auditory pathways had developed.…”

Section: Discussionmentioning

confidence: 99%

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Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery

Çeşme¹,

Alkan²,

Gültekin³

et al. 2021

Cureus

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In this study, we aimed to investigate whether there is any change in diffusion tensor imaging (DTI) parameters in ipsilateral and contralateral auditory pathways after Gamma Knife radiosurgery (GKR) in patients with vestibular schwannoma (VS) and the relationship between radiosurgery variables. MethodsSixty-six patients were evaluated with MRI and DTI before and after GKR. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral lateral lemniscus (LL), inferior colliculus (IC), medial geniculate body (MGB), and Heschl's gyrus (HG). ResultsThere was no significant difference in ADC and FA values obtained from bilateral LL, IC, and MGB before and after radiosurgery. However, there was a significant difference between pretreatment and postradiosurgery contralateral HG ADC values. The ADC values obtained from the contralateral HG and IC positively correlated with the duration after radiosurgery. As the duration after radiosurgery increases, the difference between the ADC values obtained from ipsilateral and contralateral HG also increases. ConclusionThe high ADC values in the contralateral HG after radiosurgery may indicate microstructural alterations such as demyelination and axonal loss. Radiation exposure doses to the brainstem and cochlea are the most important factors that can cause microstructural damage to the auditory pathways. When planning radiosurgery, extreme care should be taken to prevent the harmful effects of radiation on the auditory pathways.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery

Çeşme¹,

Alkan²,

Gültekin³

et al. 2021

Cureus

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“…In a study on acoustic neuromas (AN), another disease that involves auditory pathways such as NF1, ADC increase was found in lateral lemniscus, colliculus inferior, corpus geniculatum mediale and Heschl's gyrus in AN patients when compared to healthy control subjects and thought to be related to microstructural changes such as dysmyelination or loss of myelin [4]. In another study of patients with sensorineural hearing loss, it was suggested that reduced FA values with increased radial diffusivity in the colliculus inferior and lateral lemniscus caused by the dysmyelination process [15]. In our study, we found that there was an increase in ADC values of the auditory pathways in patients with NF1.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Auditory Pathways Using Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1

Meydan

Aydın

Otcu

et al. 2019

CMIR

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Aim: The aim of our study was to determine whether the diffusion properties of the auditory pathways alter between patients with Neurofibromatosis type 1 (NF1) and the healthy subjects. DTI can well demonstrate FA and ADC changes in auditory tracts and it may be a guide to identify the candidates for hearing loss among NF1 children. Methods: The study population consisted of 43 patients with NF1 and 21 healthy controls. Diffusion tensor imaging (DTI) was used to measure apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values from lemniscus lateralis, colliculus inferior, corpus geniculatum mediale and Heschl's gyrus. The results were compared with those of the control group. Results: The ADC values of lateral lemniscus, colliculus inferior and corpus geniculatum mediale were significantly higher in NF1 compared to those of the control group. On the other hand, decreased FA values were observed in lateral lemniscus and colliculus inferior in patients with NF1. Conclusion: The increase in ADC and reduction in FA in the auditory pathways of patients with NF1 may suggest microstructural alterations, such as a decrease in the number of axons, edema or inflammation in the auditory tracts.

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“…The role of DTI in improving outcomes has been established in both low and high-grade gliomas (HGG), including glioblastomas (GBM), meningiomas, and medulloblastomas. It also serves as an adjunct to the awake craniotomy for tumor resection and radiation planning for stereotactic radiosurgery [ 5 - 8 ].…”

Section: Discussionmentioning

confidence: 99%

Multimodality 3D Superposition and Automated Whole Brain Tractography: Comprehensive Printing of the Functional Brain

Konakondla

Brimley

Sublett

et al. 2017

Cureus

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Whole brain tractography using diffusion tensor imaging (DTI) sequences can be used to map cerebral connectivity; however, this can be time-consuming due to the manual component of image manipulation required, calling for the need for a standardized, automated, and accurate fiber tracking protocol with automatic whole brain tractography (AWBT). Interpreting conventional two-dimensional (2D) images, such as computed tomography (CT) and magnetic resonance imaging (MRI), as an intraoperative three-dimensional (3D) environment is a difficult task with recognized inter-operator variability. Three-dimensional printing in neurosurgery has gained significant traction in the past decade, and as software, equipment, and practices become more refined, trainee education, surgical skills, research endeavors, innovation, patient education, and outcomes via valued care is projected to improve. We describe a novel multimodality 3D superposition (MMTS) technique, which fuses multiple imaging sequences alongside cerebral tractography into one patient-specific 3D printed model. Inferences on cost and improved outcomes fueled by encouraging patient engagement are explored.

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Significant Temporal Evolution of Diffusion Anisotropy for Evaluating Early Response to Radiosurgery in Patients with Vestibular Schwannoma: Findings from Functional Diffusion Maps

Cited by 19 publications

References 24 publications

Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery

Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery

Assessment of Auditory Pathways Using Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1

Multimodality 3D Superposition and Automated Whole Brain Tractography: Comprehensive Printing of the Functional Brain

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