Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Moysés, Raquel Ajub; López, Rossana Verónica Mendoza; Cury, Patrí­cia Maluf; Siqueira, Sheila Aparecida Coelho; Curioni, Otávio Alberto; Filho, José Francisco de Góis; Figueiredo, David Livingstone Alves; Tajara, Eloíza H.; Michaluart, Pedro

doi:10.6061/clinics/2013(06)03

Cited by 27 publications

(36 citation statements)

References 24 publications

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“…Studies included: the Brazilian Head and Neck Genome Project (GENCAPO; Southern Brazil – São Paulo)[16], the Carolina Head and Neck Cancer Study (CHANCE, North Carolina, U.S.A.)[17] and the Alcohol Related Cancers and Genetic Susceptibility in Europe study (ARCAGE). [18] Data from ARCAGE included cases from Germany (36%, n=181), Italy (52%, n=259), and U.K (12%, n=62).…”

Section: Methodsmentioning

confidence: 99%

Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

et al. 2016

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Objectives To explore whether HPV-related biomarkers predict oropharyngeal squamous cell cancer (OPSCC) survival similarly across different global regions, and to explore their prognostic utility among non-oropharyngeal (non-OP) head and neck cancers. Methods Data from 1362 head and neck SCC (HNSCC) diagnosed 2002-2011 was used from epidemiologic studies in: Brazil (GENCAPO study, n=388), U.S. (CHANCE study, n=472), and Europe (ARCAGE study, n=502). Tumors were centrally tested for p16INK4a and HPV16 DNA (by PCR). Risk of mortality was examined using Cox proportional hazard models. Results There were 517 OPSCC and 845 non-OP HNSCC. Cases were primarily male (81%), ever smokers (91%), with median age of 58 years and median follow-up of 3.1 years (IQR=1.4- 5.9). Among OPSCC, the risk of mortality was significantly lower among 184 HPV-related (i.e., p16+/HPV16+) compared to 333 HPV-unrelated (p16− and/or HPV16−) cases (HR=0.25, 95%CI=0.18- 0.34). Mortality was reduced among HPV-related OPSCC cases from the U.S., Europe, and Brazil (each p≤0.01) and after adjustment, remained significantly reduced (aHR=0.34, 95%CI=0.24- 0.49). Among non-OP HNSCC, neither p16 (aHR=0.83, 95%CI=0.60-1.14), HPV16 DNA (aHR=1.20, 95%CI=0.89-1.63), or p16+/HPV16+ (aHR=0.59, 95%CI=0.32-1.08) was a significantly predictor of mortality. When interaction was tested, the effect of HPV16/p16 was significantly different in OPSCC than non-OP HNSCC (p-interaction=0.02). Conclusion HPV-related OPSCCs had similar survival benefits across these three regions. Prognostic utility of HPV among non-OP HNSCC is limited so tumor HPV/p16 testing should not be routinely done among non-OP HNSCC.

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Section: Methodsmentioning

confidence: 99%

Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

et al. 2016

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“…De igual forma se ha demostrado que el consumo de alcohol aumenta las complicaciones postratamiento e incrementa la incidencia de segundos tumores primarios y la mortalidad. El consumo de alcohol está relacionado con la aparición de metástasis ganglionares, factor pronóstico principal en el cáncer de cabeza y cuello (30) . Resulta destacable el efecto que tiene el consumo de alcohol sobre el sistema inmune, tanto en lo que respecta a la inmunidad innata como la adaptativa, promoviendo así respuestas pro inflamatorias que conducen al daño tisular en numerosos órganos y al desarrollo de cáncer (31) .…”

Section: Discussionunclassified

Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia

Arias

Estefan

Borche

et al. 2018

RMU

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ResumenIntroducción: el carcinoma escamoso de cabeza y cuello (HNSCC) es el cáncer de mayor prevalencia en la otorrinolaringología, ocupando en el Uruguay el quinto lugar en incidencia y el sexto lugar en mortalidad en hombres. El propósito de este estudio fue analizar la sobrevida global de pacientes con cáncer de cabeza y cuello en dos centros de referencia de Montevideo.Método: se analizó de forma retrospectiva la sobrevida global de 436 pacientes diagnosticados con HNSCC entre los años 2005 y 2015. Se analizó la sobrevida por método de Kaplan-Meier en relación con el estadio tumoral, topografía, estatus de tabaquismo y alcoholismo de los pacientes. Para el estudio de la interacción de las variables con posible importancia en el pronóstico se utilizó el modelo de regresión de Cox.Resultados: la mediana de sobrevida global de los pacientes con cáncer de cabeza y cuello en nuestra serie es de 35,8 meses (23,5-48,1, IC 95%), para el cáncer de laringe fue superior a la del resto de los pacientes con cáncer de otros sitios anatómicos, 77,3 (49,3-105,2, IC 95%) versus 26,2 meses (20,7-48,1, IC 95%, p < 0,001). No hubo diferencia entre la sobrevida global de tabaquistas y no tabaquistas. El grupo de los no alcoholistas presentó una mejor sobrevida global que el grupo de los alcoholistas, 72,4 (39,1-105,7, IC 95%) versus 26,7 (19,9-33,6 IC 95%). El análisis multivariante identificó el estadio y el alcoholismo como factores pronósticos independientes en nuestra serie.Conclusiones: la mediana de sobrevida global de nuestra serie es similar a la reportada en la bibliografía internacional. Los pacientes con cáncer de laringe presentan mayor sobrevida que los pacientes con cáncer de otros sitios otorrinolaringológicos. De los factores de riesgo clásicos, en nuestra serie el consumo de alcohol impacta negativamente en sobrevida de los pacientes con cáncer de cabeza y cuello.

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“…In today's time there are 4% to 13% of the cases of oral squamous cell carcinoma that affects subjects younger than 45 years of age. [4][5][6][7][8][9][10] The most frequently affected site is tongue and it is seen generally amongst alcohol and tobacco users. 4,5 Squamous cell carcinoma of lower lip is generally seen amongst subjects with exposure to sunlight.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Squamous cell carcinoma of lower lip is generally seen amongst subjects with exposure to sunlight. 6 There has been differences in the etiological factors that are responsible for causing oral squamous cell carcinoma amongst young and elderly individuals as the young individuals are exposed to the risk factors like sunlight and tobacco for a short period of time. 9,[11][12][13][14][15] Oral squamous cell carcinoma occurring amongst the younger individuals have an increased aggressiveness and poor clinical prognosis when compared to those affecting the elderly subjects.…”

Section: Introductionmentioning

confidence: 99%

“…9,[11][12][13][14][15] Oral squamous cell carcinoma occurring amongst the younger individuals have an increased aggressiveness and poor clinical prognosis when compared to those affecting the elderly subjects. 6,7,12,16,17 The prognosis of the condition is determined by the prognostic factors that would in turn determine the biological aggressiveness of the condition amongst the subjects. The various prognostic factors include regional lymph node metastasis, location of tumor and TNM classification.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical findings and risk factors associated with oral cancer: a prospective study

Gupta¹,

Singh²,

Bedi³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cancer is associated with high morbidity and mortality and therefore it represents a grave health problem worldwide. However there is scarcity of the studies in the literature regarding the prognostic factors amongst the subjects. The aim of the present study is to determine the various risk factors and the most commonly affected sites by the oral squamous cell carcinoma amongst subjects of different age groups. Methods: The present prospective comparative study was conducted at the Department of Radiotherapy at Guru Gobind Singh Medical College and Hospital during a period of three months i.e. from April 2016 to June 2016. Patients were evaluated every week for a period of approximately 2 weeks. Examination of the oral cavity was done using probe and mouth mirror by trained personnel. TNM classification was used to classify tumour. Patient’s habits like alcohol and tobacco intake were also recorded. Complete demographic information was obtained from all the patients. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Results: The study included a total of 60 subjects. There were 11 females in the study and 49 males in the study. There were 18.3% (n=11) subjects having cancer of tongue. There were 23.3% (n=14) subjects having cancer of buccal mucosa. Alveolar ridge carcinoma was seen in 8.3% (n=5) subjects. There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e. 70% (n= 38) were at stage IV A according to TNM classification. Conclusions: From the above study we can conclude that there is lack of awareness amongst the people about oral cancer. They mostly present during advanced stage of the disease. Most of the subjects are males, showing there predisposition towards harmful habits.

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Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Cited by 27 publications

References 24 publications

Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia

Clinical findings and risk factors associated with oral cancer: a prospective study

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