Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan

Pei, Jen Sheng; Chang, Wen Shin; Hsu, Pei-Chen; Chen, Chao‐Chun; Chin, Yu Ting; Huang, Tai Lin; Hsu, Yuan Nian; Kuo, Ching-Ming; Wang, Yun Chi; Tsai, Chia Wen; Gong, Chi Li; Bau, Da Tian

doi:10.21873/cgp.20178

Cited by 23 publications

(31 citation statements)

References 37 publications

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“…Oral cancer IL-16 genotyping methodology. Genomic DNA from the peripheral blood leucocytes of all oral cancer patients and matched controls were extracted using the QIAamp Blood Mini Kit (Blossom, Taipei, Taiwan) and further processed in typical polymerase chain reaction (PCR) processes as in our previous papers (20)(21)(22). The sequences of designed forward and reverse primers, corresponding restriction enzymes (New England BioLabs, Ipswich, MA, USA) and sizes of PCR products after enzyme digestion for oral cancer IL-16 genotyping identification are shown in Table II.…”

Section: Methodsmentioning

confidence: 99%

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Shih

Chang

Lee

et al. 2020

In Vivo

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Background/Aim: Interleukin-16 (IL-16) is reported to play an important role in inflammation, carcinogenesis and tumoricidal processes, however, the contribution of IL-16 genotype to oral carcinogenesis is still largely unrevealed. Thus, the study aimed to investigate the contribution of IL-16 genotypes to Taiwan oral cancer risk. Materials and Methods: The genotypes of IL-16 rs4778889, rs11556218, and rs4072111 were revealed among 958 oral cancer cases and 958 control subjects by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: First, the distributions of genotypic (p=0.0004) and allelic (p=0.0001) frequencies of IL-16 rs11556218 were significantly different between the case and control groups. In detail, the frequencies of IL-16 rs11556218 TG and GG were 28.1 and 5.8%, respectively, among oral cancer patients, significantly higher compared to those among controls (25.0% and 2.7%, respectively). Second, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Last, there was a synergistic effect of betel quid chewing behavior and risky IL-16 rs11556218 genotype on oral cancer risk. Conclusion: The study indicates that the IL-16 rs11556218 G allele synergistically interacts with betel quid chewing behavior, contributing to increased risk of oral cancer in Taiwanese. From the viewpoint of epidemiology, oral cancer is the tenth most commonly diagnosed cancer worldwide, with the highest incidence density in Taiwan (1). According to the updated annual report from the Taiwan government, oral cancer is the fourth cause of cancer-related deaths among males in Taiwan and the fifth among all Taiwanese (2). For many years, betel quid chewing habit has been identified as the most effective environmental contributor to oral cancer risk for Taiwanese (3). Although the surgery, therapy and medical caring services for oral cancer have made rapid progress during the past decade, the prevalence and death rate of oral cancer are still very high in Taiwan. Thus, early detection and prediction biomarkers for oral cancer risk are in urgent need. Interleukin-16 (IL-16) is encoded by the IL-16 gene located on chromosome 15q26.3, composed of 631 amino acids and cleaved by caspase 3 to the active IL-16 protein, comprising the 121 amino acid C-terminal (4-6). IL-16 is in charge of activating several types of cells, including CD4+ T cells, monocytes, macrophages, eosinophils, and dendritic cells, and promotes the secretion of inflammatory cytokines, such as IL-1 (7), TNF-, and IL-15 (8). Interestingly, a 1759 This article is freely accessible online.

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Section: Methodsmentioning

confidence: 99%

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Shih

Chang

Lee

et al. 2020

In Vivo

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“…A significant association of miR-146a rs2910164 with childhood ALL has been reported in an Iranian population (Hasani et al, 2014 ). This result was successfully replicated in two Chinese case-control studies (Liu et al, 2018 ; Pei et al, 2020 ). In contrast, three studies from Thailand, India and China failed to replicate the results (Chansing et al, 2016 ; Devanandan et al, 2019 ; Xue et al, 2019 ).…”

Section: Introductionmentioning

confidence: 67%

“…Previous studies found that the rs2910164 CC or CG genotype significantly increased the risk of ALL (Hasani et al, 2014 ; Liu et al, 2018 ). The miR146a rs2910164 GG genotype was significantly related to a decreased susceptibility to childhood ALL (Pei et al, 2020 ). This study confirms that the miR146a rs2910164 polymorphism (G>C) contributes to childhood ALL susceptibility among Asians.…”

Section: Discussionmentioning

confidence: 99%

Association Between the miR-146a Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population

Zou

Yin

et al. 2020

Front. Genet.

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Background: miR-146a has been demonstrated to be involved in normal hematopoiesis and the pathogenesis of many hematological malignancies by inhibiting the expression of its targets. Rs2910164(G>C) may modify the expression of the miR-146a gene, which might influence an individual's predisposition to childhood acute lymphoblastic leukemia (ALL). However, inconsistent findings have been reported on the association between the rs2910164(G>C) polymorphism and the risk of childhood ALL. Methods: A comprehensive meta-analysis was performed to accurately estimate the association between the miR-146a rs2910164 polymorphism and childhood ALL among four different genetic models. Results: This meta-analysis included Asian studies with a total of 1,543 patients and 1,816 controls. We observed a significant difference between patients and controls for the additive model (CC vs. GG: OR = 1.598, 95% CI: 1.003–2.545, P = 0.049) using a random effects model. Meanwhile, there was a trend of increased childhood ALL risk in the dominant model (CC + CG vs. GG: OR = 1.501, 95% CI: 0.976–2.307, P = 0.065), recessive model (CC vs. GG + CG: OR = 1.142, 95% CI: 0.946–1.380, P = 0.168) and allele model (C vs. G: OR = 1.217, 95% CI: 0.987–1.500, P = 0.066) between patients and controls. Conclusions: Our findings suggest that the miR-146a rs2910164 CC genotype was significantly associated with childhood ALL susceptibility.

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“…CCND1 rs9344 and rs678653 genotyping procedures. Genomic DNA was extracted from each person's peripheral blood leukocytes within 24 h after collection, carefully quantitated, diluted, and stored in a −80˚C freezer as previously described (25)(26)(27). The genotypic patterns at CCND1 rs9344 were determined for all subjects by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis as in our previous publications (28,29).…”

Section: Recruitment Of Participants Into Asthmatic and Non-asthmatic Control Groupsmentioning

confidence: 99%

Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan

Chiu²,

Hsia

et al. 2021

In Vivo

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Background/Aim: The molecular mechanisms underlying the association between cell cycle and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in asthma airway smooth muscle. We investigated whether the most frequently examined functional variants in CCND1 determine asthma susceptibility. Materials and Methods: We genotyped 651 participants for single-nucleotide polymorphisms (SNPs) at rs9344 and rs678653 on CCND1 and assessed the association of these SNPs with asthma risk. Results: Significant differences were found in the distributions of genotypic (p=0.0064) and allelic (p=0.0021) frequencies of CCND1 rs9344. In addition, AG or GG carriers had 0.63-or 0.48-fold adjusted odds ratios for asthma risk (95%confidence intervals=0.48-0.92 and 0.22-0.78, respectively) than those who carried the AA wildtype. Conclusion: Our results suggest that cell cycle regulation may play a role in asthma initiation and development, and the CCND1 rs9344 genotype may serve as an early detection marker for asthma.Asthma is a complex airway disease characterized by eosinophilic infiltration, airflow obstruction, mucus hypersecretion, goblet cell hyperplasia, and airway hyperresponsiveness and remodeling. According to a report by the World Allergy Organization, up to 300 million people suffer from asthma, and its prevalence continues to increase. Thus, asthma is a worldwide health problem (1). Clinically, asthmatic patients usually present with wheezing, cough, and dyspnea. Asthma has an estimated heritability higher than 60% (2, 3), but due to high immunological and phenotypical variations among asthmatic patients, asthma is considerably heterogeneous (4). Studies conducted in an animal disease model have suggested that approximately 200 genes are closely related to the etiology of asthma (5). Moreover, a multitude of environmental risk factors, including indoor and outdoor allergens, pollutants, smog, and air particles, may all contribute to higher risk of asthma. To date, a rather substantial body of evidence has documented typical structural alterations in the airways and lung parenchyma among asthmatic patients. These lines of evidence show that abnormal hypertrophy and hyperplasia of airway cells, such as goblet cells, smooth muscle cells, fibroblasts, and epithelial cells, take part in the processes of airway remodeling in asthma (6-10). At the molecular level, the proliferation of these human airway cells is controlled by cell cycle regulatory genes. It is possible that the genotypes of cell cycle regulatory genes may determine the personal 2041 This article is freely accessible online.

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Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan

Cited by 23 publications

References 37 publications

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Association Between the miR-146a Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population

Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan

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