Significance of the absolute lymphocyte/monocyte ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma

Dosani, Talib; Covut, Fahrettin; Beck, Rose; Driscoll, James J.; Lima, Marcos de; Malek, Ehsan

doi:10.1038/bcj.2017.60

Cited by 43 publications

(47 citation statements)

References 15 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data suggest that as many as one third of the patients with newly diagnosed multiple myeloma present with evidence of immune dysregulation as defined by abnormalities in both ALC and AMC. Consistent with previous studies, the presence of such immune dysregulation was of prognostic significance at the time of diagnosis . The data further suggest that its prognostic implications are independent of other known prognostic factors and not limited to transplant‐eligible patients.…”

Section: Discussionsupporting

confidence: 89%

“…Peripheral blood absolute lymphocyte (ALC) and absolute monocyte (AMC) counts have been used as biomarkers of the tumor microenvironment and immune surveillance in several hematologic malignancies of both myeloid and lymphoid origin . In multiple myeloma alterations in ALC, AMC, and their ratio have been found to be associated with survival outcomes at the time of diagnosis, before, and after autologous hematopoietic stem cell transplantation . In particular, early recovery of normal ALC levels (immune reconstitution) after autologous hematopoietic stem cell transplantation has been associated with improved survival outcomes .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma

et al. 2018

View full text Add to dashboard Cite

Peripheral blood biomarkers of tumor microenvironment and immune surveillance are independent prognostic factors in multiple myeloma. The timing and prognostic impact of immune reconstitution has been studied after autologous hematopoietic stem cell transplantation, less is known about its significance in newly diagnosed multiple myeloma. We studied absolute lymphocyte (ALC) and absolute monocyte (AMC) counts at the time of treatment initiation and 1 month thereafter in 771 newly diagnosed patients. Two hundred and thirty‐four patients (31%) had evidence of immune dysregulation at baseline (abnormal biomarkers). Eighty‐seven of these patients (37%) recovered normal biomarkers at 1 month (early immune reconstitution). The absence of immune dysregulation at baseline (compared to the presence thereof) was associated with better overall survival (HR 0.77, 95% CI 0.61‐0.97, P = 0.025, n = 771). The absence of immune dysregulation at 1 month (compared to the persistence or development thereof) was associated with better overall survival (HR 0.63, 95% CI 0.50‐0.80, P < 0.001, n = 771). Early immune reconstitution (compared to the persistence or development of immune dysregulation) was associated with better overall survival (HR 0.62, 95% CI 0.43‐0.92, P = 0.016, n = 771). Cytogenetic high‐risk disease was negatively, and treatment with immunomodulators positively, associated with early immune reconstitution. The presence or development of immune dysregulation in newly diagnosed multiple myeloma is an independent risk factor. The favorable impact of early immune reconstitution suggests immune dysregulation to be a potentially modifiable risk factor that may be exploited for therapeutic benefit.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…MDSCs; see [369]). Quantitative and qualitative monocyte defects have been reported, including the reduced release of proinflammatory cytokines [378][379][380][381][382][383][384][385][386].…”

Section: Functional Effects Of Imids Mediated Via Cereblonmentioning

confidence: 99%

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

Rundgren

Bruserud

Ryningen

et al. 2018

Journal of Immunological Methods

View full text Add to dashboard Cite

show abstract

“…Plotting ∆w across all patients, we find high-level changes in subpopulation abundances, which are known to be prognostic of disease progression [30]. We find that all MM patients experience a contraction in B cell numbers (Fig.…”

Section: Popalign Discovers General and Treatment-specific Signaturesmentioning

confidence: 64%

Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign

Chen

Park

Rivaud

et al. 2018

Preprint

View full text Add to dashboard Cite

Single-cell measurement techniques can now probe gene expression in heterogeneous cell populations from the human body across a range of environmental and physiological conditions. However, new mathematical and computational methods are required to represent and analyze gene expression changes that occur in complex mixtures of single cells as they respond to signals, drugs, or disease states. Here, we introduce a mathematical modeling platform, PopAlign, that automatically identifies subpopulations of cells within a heterogeneous mixture, and tracks gene expression and cell abundance changes across subpopulations by constructing and comparing probabilistic models. We apply PopAlign to analyze the impact of 42 different immunomodulatory compounds on a heterogeneous population of donor-derived human immune cells as well as patient-specific disease signatures in multiple myeloma. PopAlign scales to comparisons involving tens to hundreds of samples, enabling large-scale studies of natural and engineered cell populations as they respond to drugs, signals or physiological change.

show abstract

Significance of the absolute lymphocyte/monocyte ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma

Cited by 43 publications

References 15 publications

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign

Contact Info

Product

Resources

About