Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. A preliminary report

Yagi, H.

doi:10.1001/archderm.123.7.902

Cited by 14 publications

(8 citation statements)

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“…Serum SCC Ag values were in the normal range in patients with carcinoma in situ of Bowen's disease [21], in contrast to the elevated levels observed in larger tumors and/or associated with metastases. Yamamoto et al [22] described that serum levels of SCC Ag correlated with lesion size and epidermal damage, and decreased to nearly normal values 96 h after the tumor was removed.…”

Section: Skin Cancercontrasting

confidence: 61%

“…Yagi et al [21] reported elevated serum SCC Ag levels in patients with SCC of the skin, particularly at an advanced stage, and the usefulness of SCC Ag determinations for monitoring the course of the disease. Serum SCC Ag values were in the normal range in patients with carcinoma in situ of Bowen's disease [21], in contrast to the elevated levels observed in larger tumors and/or associated with metastases.…”

Section: Skin Cancermentioning

confidence: 99%

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SCC Antigen in Malignant and Nonmalignant Squamous Lesions

Torre¹

1998

Tumor Biol

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Squamous cell carcinoma (SCC) antigen (Ag) present and expressed in normal epithelium and epithelial tissues is used primarily as tumor marker of SCC of the uterine cervix. In this review, we considered factors interfering in vitro with the collection of samples and assay procedures, benign and malignant nongynecological diseases which may be the cause of elevated serum levels of SCC Ag. Contamination with skin or saliva strongly influences SCC Ag levels. SCC Ag is elevated in several benign lesions, including pulmonary (tuberculosis, adult respiratory distress syndrome, pulmonary infiltration with eosinophilia, sarcoidosis, bronchogenic cyst) and skin (eczema, pemphigus, erythroderma epidermitis, psoriasis) diseases. Elevations are observed in SCC malignancies of the head and neck, esophagus, skin, lung, urothelium, anal canal and vulva.

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Section: Skin Cancercontrasting

confidence: 61%

Section: Skin Cancermentioning

confidence: 99%

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

Torre¹

1998

Tumor Biol

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“…False-positive elevations of serum SCC antigen have also been found in 11% of patients with inflammatory lung diseases and in 53% of patients with severe renal malfunctioning [60][61][62]. Elevation of serum SCC antigen values was observed in patients with advanced stage squamous cell carcinomas of the skin (including head and neck), lung, and of other origins, but this is not expected to interfere with the follow-up procedure of cervical cancer patients [60][61][62][63][64].…”

Section: Specificity During the Follow-up Periodmentioning

confidence: 99%

The Clinical Value of Squamous Cell Carcinoma Antigen in Cancer of the Uterine Cervix

et al. 1998

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A review is given of the clinical use and interpretation of serum tumor marker levels during the treatment of patients with cancer of the uterine cervix. Pretreatment serum squamous cell carcinoma (SCC) antigen provides a new prognostic factor in early stage squamous cell carcinoma of the uterine cervix. Elevated serum values of SCC antigen at the time of diagnosis of stage IB and IIA cervical cancer indicate a 3 × increased risk of tumor recurrence, independent of tumor diameter, grade or the presence of lymph node metastases. High pretreatment SCC antigen levels could therefore be used to select ‘high-risk’ patients for adjuvant therapy. Measurement of the serum SCC antigen levels provides a means of monitoring the effect of therapy. During the postoperative follow-up of patients with localized cancer of the uterine cervix the measurement of SCC antigen can lead to the early detection of recurrent disease when curative therapy is still an option. The profile of serum SCC antigen parallels the response to radiotherapy and provides a way of evaluating the effectiveness of chemotherapy. Serial measurements after surgery and during radio- and chemotherapy demonstrate that SCC antigen is a more sensitive marker for recognizing tumor progression or recurrence than CYFRA-21.1, TPS or CEA. When following up patients with a pure adenocarcinoma of the cervix measurements of serum CA 125 and CEA are preferred over SCC antigen measurements.

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“…Elevated marker levels correlate with stage of the disease [7][8][9] and predict recurrence [10][11][12]. SCC-Ag is also a useful tumor marker for cutaneous SCC, but mostly serum levels increase only in patients with a large primary tumor or with metastatic lesions [13]. Serum levels of SCC-Ag reflect the clinical manifestation of acrokeratosis paraneoplastica (Bazex syndrome), a distinct dermatosis usually associated with SCC [14].…”

Section: Case Reportmentioning

confidence: 99%

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen

Lehtovirta¹,

Henrik²,

Vartiainen³

et al. 1999

Tumor Biol

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Squamous cell carcinoma antigen (SCC-Ag) has been shown to be elevated in patients with epidermoid carcinoma of the cervix but also in patients with benign tumors of epithelial origin and in benign skin disorders. Elevated serum levels of the free β subunit of human chorionic gonadotropin (hCGβ) have been observed in patients with cancer of different types, and cancer aggressiveness is related to hCGβ expression. Therefore, we expected that extensive metastatic skin dissemination of gynecologic malignancies would cause a rise in the serum levels of SCC-Ag and hCGβ. The serum levels of SCC-Ag, hCGβ and CA 125 were monitored in 2 patients with extensive skin dissemination of ovarian and endometrial adenocarcinoma. Skin metastases had no effect on serum levels of SCC-Ag but they caused an increase in serum levels of hCGβ. SCC-Ag is not a marker for metastatic skin lesions of gynecologic carcinomas of nonepidermoid origin. hCGβ expression is associated with aggressiveness of cancer and may be a useful marker indicating therapy resistance.

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Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. A preliminary report

Cited by 14 publications

References 0 publications

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

The Clinical Value of Squamous Cell Carcinoma Antigen in Cancer of the Uterine Cervix

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen

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Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. A preliminary report

Cited by 14 publications

References 0 publications

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

The Clinical Value of Squamous Cell Carcinoma Antigen in Cancer of the Uterine Cervix

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCG&beta; but Not Those of SCC Antigen

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Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen