In this study, unsteady boundary layer flow with Casson nanofluid within the sight of chemical reaction toward a stretching sheet has been analyzed mathematically. The fundamental motivation behind the present examination is to research the influence of different fluid parameters, in particular, Casson fluid
β0.25em
(
0.2
≤
β
≤
0.4
), thermophoresis
N
t0.25em
(
0.5
≤
N
t
≤
1.5
), magnetohydrodynamic
M0.25em
(
3.0
≤
M
≤
5.0
), Brownian movement
N
b0.25em
(
0.5
≤
N
b
≤
2.0
), Prandtl numberty, unsteadiness parameter
A0.25em
(
0.10
≤
A
≤
0.25
), chemical reaction parameter
γ0.25em
(
0.1
≤
γ
≤
0.8
), and Schmidt number
S
c0.25em
(
1.0
≤
S
c
≤
3.0
) on nanoparticle concentration, temperature, and velocity distribution. The shooting procedure has been adopted to solve transformed equations with the assistance of Runge–Kutta Fehlberg technique. The impact of different controlling fluid parameters on flow, heat, and mass transportation are depicted in tabular form and are shown graphically. Additionally, values of skin friction coefficient, Nusselt number, and Sherwood number are depicted via tables. Present consequences of the investigation for Nusselt number are related with existing results in writing by taking
N
b
infixafter=
0 and
N
t
infixafter=
0 where results are finding by utilization of MATLAB programming. Findings of current research help in controlling the rate of heat and mass aspects to make the desired quality of final product aiding manufacturing companies and industrial areas.