Archives of Dermatology
 1992
DOI: 10.1001/archderm.128.5.663
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Significance of DNA ploidy in cutaneous lesions

Arlene J. Herzberg
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Cited by 10 publications

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“…Conflicting data about the significance of ICM‐DNA in skin tumours reported by earlier studies are, at least in part, due to significant differences in methods of specimen preparation, instrumentation and interpretation of DNA data. 7 Concerning DNA cytometry of sweat gland tumours, only a few case reports 23–25 and a small study of nine poroma cases 26 have been published. In none of these reports was ICM‐DNA applied.…”
Section: Discussionmentioning
confidence: 99%
“…DNA image cytometry (ICM‐DNA) represents such an additional method, which has been proven to be helpful in identifying prospective malignancy in various cutaneous and extracutaneous tumours. 6–8 We previously demonstrated that ICM‐DNA can be useful in distinguishing between malignant and benign clear cell hidradenoma. 9 To the best of our knowledge, further studies concerning ICM‐DNA in sweat gland tumours have not been conducted to date.…”
mentioning
confidence: 99%
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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Conflicting data about the significance of ICM‐DNA in skin tumours reported by earlier studies are, at least in part, due to significant differences in methods of specimen preparation, instrumentation and interpretation of DNA data. 7 Concerning DNA cytometry of sweat gland tumours, only a few case reports 23–25 and a small study of nine poroma cases 26 have been published. In none of these reports was ICM‐DNA applied.…”
Section: Discussionmentioning
confidence: 99%
“…DNA image cytometry (ICM‐DNA) represents such an additional method, which has been proven to be helpful in identifying prospective malignancy in various cutaneous and extracutaneous tumours. 6–8 We previously demonstrated that ICM‐DNA can be useful in distinguishing between malignant and benign clear cell hidradenoma. 9 To the best of our knowledge, further studies concerning ICM‐DNA in sweat gland tumours have not been conducted to date.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…DAPI-DNA microfluorometric analyses have been reported to reflect sensitively the biologic behavior of melanotic skin lesions (7,8). Paraffin-embedded specimens may vary with fluorochrome staining (14). However, DAPI produces fluorescence by combining with the adenine-thymine bond of DNA, which minimizes the nonspecific fluorescence of paraffinembedded specimens (15).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Therefore, additional methods are desirable. DNA image cytometry (DNA ICM) has proved to be useful in identifying prospective malignancy in various cutaneous and extracutaneous tumours 9–11 . Regarding cutaneous adnexal tumours, we have demonstrated in previous studies that DNA ICM can be helpful in detecting prospective malignancy in sebaceous tumours of the Muir–Torre syndrome 12 and sweat gland tumours 13,14 .…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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