2019
DOI: 10.1007/s10120-019-01001-2
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Abstract: Background The purpose of this study was to investigate the prognostic significance of computed tomography (CT) attenuation and F-18 fluorodeoxyglucose (FDG) uptake of visceral adipose tissue (VAT) to predict peritoneal recurrence-free survival (RFS) as well as RFS and overall survival (OS) in patients with advanced gastric cancer (AGC). Methods We retrospectively enrolled 117 patients with AGC who underwent staging FDG positron emission tomography (PET)/CT and subsequent curative surgical resection. CT attenu… Show more

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Cited by 28 publications
(49 citation statements)
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“…Similar results were obtained in extremity sarcoma, prostate cancer, pancreatic adenocarcinoma and head and neck cancer [14,17,33,34]. Notably, the prognostic impact of fat tissue attenuation was also assessed in a retrospective study of gastric cancer [16]. In this study, high VAT density patients showed worse OS and relapse-free survival compared to patients with low values.…”
Section: Discussionsupporting
confidence: 78%
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“…Similar results were obtained in extremity sarcoma, prostate cancer, pancreatic adenocarcinoma and head and neck cancer [14,17,33,34]. Notably, the prognostic impact of fat tissue attenuation was also assessed in a retrospective study of gastric cancer [16]. In this study, high VAT density patients showed worse OS and relapse-free survival compared to patients with low values.…”
Section: Discussionsupporting
confidence: 78%
“…Hence, Dahlman and others propose that adipose tissues of higher density would be composed of shrunken adipocytes, increased fibrosis and decreased fat cell volume, resulting from changes in extracellular matrix pathway regulations. These events would occur following adipose tissue remodeling associated with aging, which presents overlapping features with cancer-associated wasting [30,31], or pathological conditions such as obesity or cancer [16].…”
Section: Discussionmentioning
confidence: 99%
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“…Currently, clinical studies have investigated the use of CT-attenuation and FDG uptake of adipose tissue to estimate the qualitative change in adipose tissue in various malignant diseases [22][23][24][25][26]40].…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the quantity of adipose tissue, recent studies have employed CT-attenuation on non-contrast enhanced CT images and 18 F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) to investigate the clinical value of qualitative characteristics of adipose tissue in cancer patients [22,23]. These two imaging parameters were found to be related to fibrotic and inflammatory changes in adipose tissue and were significantly associated with the prognosis of several malignant diseases [22][23][24][25]. Considering the significant in vitro interaction between PPAT and prostate cancer cells [10,14,17], qualitative characteristics of PPAT on imaging studies may be associated with clinical characteristics and progression of prostate cancer.…”
Section: Introductionmentioning
confidence: 99%