Significance of confirming Epstein-Barr virus nuclear antibody as tumor marker

Stošić-Divjak, Svetlana; Dukić, Vojko B; Boričić, Ivan; Račić, Alek J.; Divjak, Isidora; Krsmanovic, V.

doi:10.2298/vsp0707459s

Cited by 1 publication

(1 citation statement)

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“…UCNT is very rare tumour in Serbia (incidence in Belgrade less than 0.5 per 100,000 people per year) [7]. The association between EBV and UCNT in our country was recently confirmed by detection of anti-EBV antibodies in the serum of patients with UCNT [8]. But, there have been no published Serbian reports about presence of EBV in tissue of UCNT and its prognostic significance.…”

Section: Introductionmentioning

confidence: 60%

Prognostic significance of clinical parameters and Epstein-Barr virus infection in non-endemic undifferentiated carcinoma of nasopharyngeal type: a Serbian report

Terzić

Boricic

Pendjer³

et al. 2010

Med Oncol

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Undifferentiated carcinoma of nasopharyngeal type (UCNT) is very rare tumour in Serbia, like in most of the countries of Europe, with incidence less than 0.5 per 100,000 people per year. The aim of this study was to assess the presence of Epstein-Barr virus (EBV) in the UCNT of a non-endemic population in Serbia and identify the main clinical parameters that interfere with patients' survival rate. This study included 102 patients with UCNT who were diagnosed between 1996 and 2003. Biopsies were analysed for EBV-encoded RNA (EBER) by in situ hybridization of tumour tissue microarray. Of 102 patients, 76 were men and 26 were women with ages ranging between 18 and 82 years (median 52.5, mean 53.0±14.1). Survival rates were 80, 39 and 31% for one, three and five years, respectively. Ninety-three of 102 cases were EBER positive (92%). Factors with unfavourable prognostic values were age over 50 years at the time of diagnosis, advanced clinical stage, therapy other than chemoradiotherapy and EBER negative status. In regard to the clinical data, EBER expression in UCNT was shown to be a strong independent predictor of overall and progression-free survival. To our knowledge, the current report constitutes the largest European non-endemic series of UCNT samples from a single institution with correlation between survival and clinical parameters/EBER status.

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Section: Introductionmentioning

confidence: 60%