Significance of brain natriuretic peptides in patients on continuous ambulatory peritoneal dialysis

Nakatani, T.; Naganuma, Takeshi; Masuda, Chikayoshi; Uchida, Junji; Sugimura, T; Sugimura, Kazunobu

doi:10.3892/ijmm.10.4.457

Cited by 18 publications

(24 citation statements)

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“…Our results clearly show that patients on HD are more likely to have elevated levels of NT-proBNP compared to patients on CAPD, and this finding may suggest that from the cardiovascular stand point CAPD is a better alternative to HD for renal replacement therapy. These data are consistent with previously mentioned studies [27][28][29] . Whether an advantage predicted by a marker such as NT-proBNP leads to an actual morbidity or mortality benefit cannot be determined from the present study, and this clinically relevant hypothesis warrants further investigation.…”

Section: Abnormal Nt-probnp In Hd Vs Capdsupporting

confidence: 83%

“…The thought that such volume shifts would have adverse effect on the cardiovascular system have been postulated before, and there is an accumulating body of evidence suggesting that BNP and NT-proBNP levels are higher among patients on HD (ref. [27][28][29][30]. No previous studies to our knowledge assessed NT-proBNP according to the level of preservation of the left ventricular systolic function.…”

Section: Abnormal Nt-probnp In Hd Vs Capdmentioning

confidence: 99%

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Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients

Ludka¹,

Špinar²,

Tomandl³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Plasma N-terminal fragment of pro brain natriuretic peptide (NT-proBNP) concentration is elevated in cardiovascular diseases such as congestive heart failure, where increased levels of NT-proBNP indicate cardiac dysfunction, hypervolemia, and higher risk of hospitalization and death. These associations apply also to patients with severe impairment of kidney function. Little is known about diferences in plasma level of NT-proBNP in patients receiving hemodialysis (HD) versus those receiving continuous ambulatory peritoneal dialysis (CAPD). Aim. To evaluate differences in plasma NT-proBNP concentration between HD and CAPD patients. Methods. Plasma NT-proBNP concentration was prospectively measured in consecutive patients receiving either HD or CAPD at our hospital center. All other standard clinical parameters were recorded. The correlation between plasma NT-proBNP concentration and the type of dialysis was then examined. Results. We studied 99 consecutive patients on HD (age 62 ± 15 years, 66% male) and 18 consecutive patients on CAPD (age 56 ± 18 years, 67% male). Both groups had similar baseline characteristics including duration of dialysis, left ventricular function and mass, and cardiothoracic ratio. Significantly more patients on HD had abnormal NTproBNP levels compared to patients on CAPD (97% vs 44%; P<0.0001), and this difference remained highly significant when using various NT-proBNP cut off values. A subgroup analysis revealed that the lower NT-proBNP levels of CAPD patients are most pronounced in patients with preserved left ventricular ejection function. As expected, NT-proBNP levels correlated negatively with left ventricular function and positively with cardiothoracic ratio, and this applied to both HD and CAPD groups. Conclusion. The lower concentration of NT-proBNP in patients on CAPD compared to those on HD suggests that CAPD produces lesser hemodynamic stress, especially in patients with preserved left ventricular systolic function. Even though increased NT-proBNP levels have been shown to predict increased morbidity and mortality, further studies are necessary to assess the long term benefit of CAPD compared to HD.

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Section: Abnormal Nt-probnp In Hd Vs Capdsupporting

confidence: 83%

Section: Abnormal Nt-probnp In Hd Vs Capdmentioning

confidence: 99%

Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients

Ludka¹,

Špinar²,

Tomandl³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Both BNP-32 (7,8) and NT-BNP-76 (9) correlate positively with left ventricular mass index and negatively with left ventricular ejection fraction in patients who are on dialysis. The influence of reduction in GFR on levels of BNP is an important reason that its role is not established in CKD.…”

mentioning

confidence: 99%

B-type Natriuretic Peptides Strongly Predict Mortality in Patients Who Are Treated with Long-Term Dialysis

Roberts¹,

Srivastava²,

Macmillan³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: Left ventricular abnormalities contribute to cardiovascular disease in patients with chronic kidney disease and may be detected by measurement of B-type natriuretic peptide in serum.Design, setting, participants, & measurements: In a prospective cohort study of predialysis patients, patients who were on dialysis, and kidney transplant recipients, serum was collected and assayed for both B-type natriuretic peptide and its N-terminal fragment. Median levels were compared using nonparametric tests, and predictors of B-type natriuretic peptide were determined by linear regression. Survival analysis and Cox regression were performed to examine the association of levels of B-type natriuretic peptide with cardiovascular events and death.Results: Levels of B-type natriuretic peptide were highest in patients who were on dialysis. Patients who were receiving dialysis and had known cardiovascular disease, were not on the waiting list for kidney transplantation, or had left ventricular systolic dysfunction on echocardiography had significantly higher levels of B-type natriuretic peptide than patients without these characteristics. Glomerular filtration rate was an important predictor of B-type natriuretic peptide levels for patients who were not on dialysis (predialysis and renal transplant recipients). Left ventricular systolic dysfunction predicted B-type natriuretic peptide levels in patients who were on dialysis. Both forms of B-type natriuretic peptide were associated with a two-to three-fold increased risk for death in patients who were on dialysis.Conclusions: Levels of B-type natriuretic peptide are greatest in patients who are on dialysis and have cardiovascular comorbidities and are strong predictors of death.

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“…ANP and BNP decrease significantly during hemodialysis treatment but increase again during the interdialytic interval (1,2,4,6,7,14,17,20 -23). Levels in patients on peritoneal dialysis (PD) have been found to be lower than in patients on hemodialysis (11,24 -26), but the correlations with left ventricular function and structure are maintained in both types of dialysis modalities (11,15,27,28).…”

mentioning

confidence: 99%

Predictive Value of Brain Natriuretic Peptides in Patients on Peritoneal Dialysis

Paniagua

Amato

Mujais

et al. 2008

Clinical Journal of the American Society of Nephrology

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Significance of brain natriuretic peptides in patients on continuous ambulatory peritoneal dialysis

Cited by 18 publications

References 0 publications

Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients

Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients

B-type Natriuretic Peptides Strongly Predict Mortality in Patients Who Are Treated with Long-Term Dialysis

Predictive Value of Brain Natriuretic Peptides in Patients on Peritoneal Dialysis

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