Signet-ring cell carcinoma of the colon: A case report of a 9-year-old boy

Yang, Shaobo; Liu, Gongbao; Zheng, Shan; Dong, Ke; Ma, Yangyang; Xiao, Xia

doi:10.3892/ol.2015.3403

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…However, for patients with cancer staging III-IV, postoperative adjuvant chemotherapy is important to eradicate micrometastases, thereby reducing disease recurrence and increasing the cure rate [33]. At present, adjuvant chemotherapy with Oxaliplatin and 5-fluorouracil-based antineoplastic agents were among the commonly used chemotherapy combinations, as it has been found to reduce the rate of relapse and increase survival rates [3,9]. In the modern era, monoclonal antibody target therapy such as bevacizumab also showed promising results for metastatic colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In the modern era, monoclonal antibody target therapy such as bevacizumab also showed promising results for metastatic colorectal cancer. Postoperative radiotherapy is unable to increase the survival rate of patients with tumors that are difficult to completely resect; however, palliative radiotherapy may effectively relieve the clinical symptoms of metastasized lesions [3,34].…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer (CRC) is a rare pediatric tumor, representing only 1% of all pediatric malignancies, with an incidence rate of between 1 and 8 cases per million children worldwide [1][2][3]. It is also the most common primary gastrointestinal malignancy in children [4,5].Childhood CRCs more frequently develops in children without known predisposing syndromes, nonetheless, 10% to 30% of it have predisposing factors [4] which include familial adenomatous polyposis (FAP), ulcerative colitis, Crohn disease and Peutz-Jegher syndrome [6].…”

Section: Introductionmentioning

confidence: 99%

“…It is not clear why children more commonly present at a later stage than adults, but postulated causes include delays in diagnosis owing to its low incidence and mimicry of more common pathologies including infectious and inflammatory bowel disease [12]. The majority of cases of pediatric colorectal carcinoma are identified in older children: 70-95% of cases occur in children >10 years of age [1,3,[13][14][15]. Childhood colon cancers have a poor prognosis, with a reported 5-year survival ranging from 7 to 12% [1,3,[14][15][16][17].…”

mentioning

confidence: 99%

“…The majority of cases of pediatric colorectal carcinoma are identified in older children: 70-95% of cases occur in children >10 years of age [1,3,[13][14][15]. Childhood colon cancers have a poor prognosis, with a reported 5-year survival ranging from 7 to 12% [1,3,[14][15][16][17]. This poor prognosis may be related to a delayed diagnosis, to the higher incidence of malignant histology, and to the potential of a more rapid tumor growth in a subject who is actively growing [18].…”

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confidence: 99%

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Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

Ognibene¹,

Basile²,

Schiavone³

et al. 2016

JGPLD

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Colorectal carcinomas are rare disease in the pediatric population, especially without known risk factors. The present article reports the case of a 15 year old boy with sporadic colon carcinoma who presented with acute intestinal obstruction symptoms during a soccer match. An annular colonic mass proximal to the hepatic flexure causing mechanical obstruction was observed on abdominal enhanced magnetic resonance. The diagnosis was confirmed by emergency laparotomy which identified an infiltrative and stenosing colonic mass, with serosal involvement and hepatic metastasis. Histological examination of the mass revealed a moderately differentiated adenocarcinoma. The present study aimed to suggest that malignancies should be considered by pediatricians and pedi¬atric surgeons for differential diagnosis when patients present with intestinal obstruction symptoms such as unexplained persistent constipation, abdominal distension or bleeding per rectum, as early diagnosis and treatment decreases the mortality rate of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

Ognibene¹,

Basile²,

Schiavone³

et al. 2016

JGPLD

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Colorectal cancer under 20 years old: a retrospective analysis from three tertiary hospitals

Zhou

Xiao

Wang

et al. 2020

J Cancer Res Clin Oncol

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Purpose Colorectal cancer (CRC) rarely occurs in children and adolescents. This study aimed to perform a retrospective analysis and disclose more detailed information about CRC in patients under 20 years old. Methods Medical records of CRCs in patients under 20 years old referred to three tertiary hospitals in China from September 2000 to July 2019 were retrospectively reviewed. Clinicopathological characteristics, treatment processes and laboratory findings were summarized and treatment outcomes and prognostic factors were analyzed. Results A total of 33,394 CRC medical records were analyzed, and we identified seventy (0.21%) CRCs in patients under 20. The most common primary tumor location was the left hemicolon (35.7%). The prominent pathological types were mucinous adenocarcinoma (22.9%) and signet ring cell carcinoma (22.9%). Nearly half (47.1%) of the patients presented with distant metastasis at diagnosis. The fractions of patients with deficient mismatch repair (dMMR) protein expression and microsatellite instability-high (MSI-H) were 23.8% (5/21) and 71.4% (5/7), respectively. Forty-four patients underwent radical surgery. Fifty-five patients received chemotherapy and six patients received radiotherapy. One dMMR/MSI-H rectal cancer patient received immunotherapy and achieved a clinically complete response. The median overall survival (OS) time was 80 months. The 3-year and 5-year OS rates were 61.8% and 57.2%, respectively. An absence of distant metastasis was a favorable factor for OS. For stage II/III CRCs, classic adenocarcinoma and radical surgery were favorable factors for OS. For stage IV CRCs, primary location at the colon was a favorable factor for OS. Conclusion Child and adolescent CRC patients are likely to have distant metastasis, undifferentiated, left hemicolon location, and a dMMR/MSI-H phenotype at diagnosis. Additional efforts are needed to improve their survival outcomes.

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Prognosis of Signet Ring Cell Carcinoma of the Colon and Rectum and their Distinction of Mucinous Adenocarcinoma with Signet Ring Cells. A Comparative Study

Pozos-Ochoa

Lino-Silva

León-Takahashi

et al. 2017

Pathol. Oncol. Res.

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Signet ring cell carcinoma (SRCC) of the colorectum is very rare, comprising between <1% and 2.4% cases of colorectal cancer. Patients' prognoses are poor. Several case reports had described as SRCC cases that are mucinous adenocarcinomas (MAC) with signet ring cells (SRC). In order to clearly delineate between MAC with SRC and SRCC, we performed a retrospective study at a national cancer referral center in which survival and clinicopathological characteristics between these two forms were compared and also SRCC were characterized by immunohistochemistry. We retrieved 32 cases that had been classified as either SRCC or MAC with SRC subtypes. It was noted that SRCC patients presented at older ages, demonstrated more advanced clinical stages, lymphovascular invasion, lymph node metastases, and higher carcinoembrionic levels than MAC with SRC patients. Regarding SRCC immunophenotype, 50% showed loss of CDX2 expression, 33% were CK20 negative, 41.7% were CK7 positive, and 25% were negative for both CK7 and CK20. For the MAC with SRC and SRCC groups, the median disease-specific survival (DSS) was 46.1 months (95% CI 36.9-55.25) and 22.4 months (95% CI 5.1-39.7 [p = 0.039]), respectively. The 3-year DSS was 80.7% and 28.6% (p = 0.017) for the MAC and SRCC patients, respectively. Univariate and multivariate analyses showed that SRCC was associated with decreased survival. SRCC had several clinicopathological features that permitted differentiation of MAC with SRC from SRCC patients, who had a poor DSS. A differential diagnosis for metastatic gastric cancer is only possible with a good clinicopathological correlation.

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Signet-ring cell carcinoma of the colon: A case report of a 9-year-old boy

Cited by 6 publications

References 12 publications

Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

Colorectal cancer under 20 years old: a retrospective analysis from three tertiary hospitals

Prognosis of Signet Ring Cell Carcinoma of the Colon and Rectum and their Distinction of Mucinous Adenocarcinoma with Signet Ring Cells. A Comparative Study

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