2018
DOI: 10.18632/aging.101496
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Abstract: There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly available RNA sequencing data from Genotype-Tissue Expression (GTEx) project. GTEx provided RNA sequencing data of suprapubic (n=228) and lower leg (n=349) skins, which are photo-protected and photo–damag… Show more

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Cited by 28 publications
(23 citation statements)
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References 76 publications
(81 reference statements)
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“…SPRR2F was identified as a targeted gene (21) in epithelial malignant tumors and some other members of the SPRR protein family , which were considered to augment epithelial proliferation and initiation of malignancy (22) . Furthermore, SPRRs were also up-regulated after UV exposure (23) , which indicated that this gene family might mediate some pathological changes in causing skin phototoxicity and may also play a crucial role in melanoma progression. Based on these studies along with the results of our study, it is reasonable to use genetic risk score to evaluate the outcome of melanoma.…”
Section: Discussionmentioning
confidence: 97%
“…SPRR2F was identified as a targeted gene (21) in epithelial malignant tumors and some other members of the SPRR protein family , which were considered to augment epithelial proliferation and initiation of malignancy (22) . Furthermore, SPRRs were also up-regulated after UV exposure (23) , which indicated that this gene family might mediate some pathological changes in causing skin phototoxicity and may also play a crucial role in melanoma progression. Based on these studies along with the results of our study, it is reasonable to use genetic risk score to evaluate the outcome of melanoma.…”
Section: Discussionmentioning
confidence: 97%
“…The deterioration of ribosome presence (59) and function (60) during ageing has been shown previously in mice. In addition, it is well established that photoageing grossly affects gene expression in human keratinocytes (16,61). A decline in ribosome function and in RNA-binding proteins (Fig 4B, Peptide location fingerprinting allows the assessment of protein modifications both on a molecular scale by visualising significant differences in peptide yield along a protein's structure (Fig.…”
Section: Classification and Pathway Analysis Of Skin Proteins With Phmentioning
confidence: 99%
“…As a consequence of higher protein turnover, it is likely that damage manifests primarily in the epidermis as changes in the ability of cells to synthesise functional proteins (16). Due to the biological complexity of skin and these varied mechanisms of damage, the photoageing process creates a spectrum of modifications to proteins which are challenging to track and distinguish using a single methodology.…”
Section: Introductionmentioning
confidence: 99%
“…In order to generate more wrinkles, vasculature structures are needed to develop. Numerous reports suggested that angiogenesis plays a significant role in inducing wrinkle formation in photo-damaged skin [142]. Among harmful environmental factors that contribute to extrinsic aging, long-term effects of repeated exposure to ultraviolet light are the most significant and are referred to as photoaging.…”
Section: Photoagingmentioning
confidence: 99%