2013
DOI: 10.1038/nrclinonc.2013.162
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Signatures of mutational processes in cancer—a big step closer

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Cited by 4 publications
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“…A few driver mutations [6,7] ultimately lead to cancer, while the role, if any, of the vast majority of mutations, termed “passengers”, during tumor development is poorly understood [8,9]. One crucial principle stands out: mutations can be classified into ‘families’ based upon their flanking DNA sequences [10,11]. Different mutagenic processes generate mutations within different contexts of a neighboring nucleotide sequence (the bases upstream and/or downstream of the mutations, termed “mutation signatures”).…”
Section: Introductionmentioning
confidence: 99%
“…A few driver mutations [6,7] ultimately lead to cancer, while the role, if any, of the vast majority of mutations, termed “passengers”, during tumor development is poorly understood [8,9]. One crucial principle stands out: mutations can be classified into ‘families’ based upon their flanking DNA sequences [10,11]. Different mutagenic processes generate mutations within different contexts of a neighboring nucleotide sequence (the bases upstream and/or downstream of the mutations, termed “mutation signatures”).…”
Section: Introductionmentioning
confidence: 99%
“…(2) C>T transitions at methylated cytosine in CG base pairs display a higher frequency than expected (Alexandrov et al, 2013a;Alexandrov et al, 2013b;Burgess, 2019;Hutchinson, 2013;Petljak et al, 2019). Therefore, activation-induced cytidine deaminase (AID) (Barlow et al, 2013;Greaves, 2018;Petersen-Mahrt et al, 2002) and apolipoprotein B mRNA editing enzyme catalytic (APOBEC) family (Alexandrov et al, 2013b;Buisson et al, 2019;Hutchinson, 2013;McGranahan et al, 2017;Robertson et al, 2017) catalyzing the deamination of C were identified as ESMs. Unfortunately, some cancers such as kidney renal clear cell carcinoma (KIRC) show the low mutation proportion at CG base pairs and low APOBEC expression (Burns et al, 2013b), raising the potential roles of unidentified ESMs.…”
Section: Introductionmentioning
confidence: 99%
“…Transition is a substitution in which one base is replaced by another of the same class (purine or pyrimidine), while transversion is a substitution in which a purine is replaced with a pyrimidine or vice versa (Figure 1B). (2) C>T transitions at methylated cytosine in CG base pairs display a higher frequency than expected (Alexandrov et al, 2013a;Alexandrov et al, 2013b;Burgess, 2019;Hutchinson, 2013;Petljak et al, 2019). Therefore, activation-induced cytidine deaminase (AID) (Barlow et al, 2013;Greaves, 2018;Petersen-Mahrt et al, 2002) and apolipoprotein B mRNA editing enzyme catalytic (APOBEC) family (Alexandrov et al, 2013b;Buisson et al, 2019;Hutchinson, 2013;McGranahan et al, 2017;Robertson et al, 2017) catalyzing the deamination of C were identified as ESMs.…”
Section: Introductionmentioning
confidence: 99%
“…(2) C>T transitions at methylated cytosine in CG base pairs display a higher frequency than expected (Alexandrov et al, 2013a;Alexandrov et al, 2013b;Burgess, 2019;Hutchinson, 2013;Petljak et al, 2019). Therefore, activation-induced cytidine deaminase (AID) (Barlow et al, 2013;Greaves, 2018;Petersen-Mahrt et al, 2002) and apolipoprotein B mRNA editing enzyme catalytic (APOBEC) family (Alexandrov et al, 2013b;Buisson et al, 2019;Hutchinson, 2013;McGranahan et al, 2017;Robertson et al, 2017) catalyzing the deamination of C were identified as ESMs. Unfortunately, some cancers such as kidney renal clear cell carcinoma (KIRC) show the low mutation proportion at CG base pairs and low APOBEC expression (Burns et al, 2013b), raising the potential roles of unidentified ESMs.…”
Section: Introductionmentioning
confidence: 99%