Signalling in taste receptor cells: cAMP-dependent protein kinase causes depolarization by closure of 44 pS K-channels

Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells

“…Regulation of L‐type (especially Ca v 1.2), but not P/Q‐type, channels by PKA phosphorylation is well documented in cardiac and skeletal muscle, neurons, and chromaffin cells (reviewed in McDonald et al 1994). In patch‐clamp recordings, some cells in frog and rat taste buds are strongly depolarized by cAMP elevation, an effect attributed to PKA‐mediated block of a K + current (Tonosaki & Funakoshi, 1988; Avenet et al 1988; Cummings et al 1993, 1996). In intact tongue preparations, membrane‐permeant cAMP analogues produce bursts of action potentials in taste buds and/or afferent nerves (Cummings et al 1993).…”

Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells

“…Regulation of L‐type (especially Ca v 1.2), but not P/Q‐type, channels by PKA phosphorylation is well documented in cardiac and skeletal muscle, neurons, and chromaffin cells (reviewed in McDonald et al 1994). In patch‐clamp recordings, some cells in frog and rat taste buds are strongly depolarized by cAMP elevation, an effect attributed to PKA‐mediated block of a K + current (Tonosaki & Funakoshi, 1988; Avenet et al 1988; Cummings et al 1993, 1996). In intact tongue preparations, membrane‐permeant cAMP analogues produce bursts of action potentials in taste buds and/or afferent nerves (Cummings et al 1993).…”

Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster

“…Thus, we have identified, for the first time, the specific AC in sugar perception in Drosophila . In vertebrates, it has already been reported that the cAMP mediating pathway is involved in sugar perception (Avenet et al. , 1988a, b; Striem et al.…”

“…, 2005). In vertebrates, although cAMP mediates sugar perception (Avenet et al. , 1988a, b), the Gq/phospholipase C and gustducine/phosphodiesterase pathway (McLaughlin et al.…”

“…, 2002). The AC/cAMP pathway is already known to participate in various physiological signaling, including sugar‐taste perception in vertebrates (Avenet et al. , 1988a, b; Striem et al.…”

Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells

“…Regulation of L‐type (especially Ca v 1.2), but not P/Q‐type, channels by PKA phosphorylation is well documented in cardiac and skeletal muscle, neurons, and chromaffin cells (reviewed in McDonald et al 1994). In patch‐clamp recordings, some cells in frog and rat taste buds are strongly depolarized by cAMP elevation, an effect attributed to PKA‐mediated block of a K + current (Tonosaki & Funakoshi, 1988; Avenet et al 1988; Cummings et al 1993, 1996). In intact tongue preparations, membrane‐permeant cAMP analogues produce bursts of action potentials in taste buds and/or afferent nerves (Cummings et al 1993).…”

Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster

“…Thus, we have identified, for the first time, the specific AC in sugar perception in Drosophila . In vertebrates, it has already been reported that the cAMP mediating pathway is involved in sugar perception (Avenet et al. , 1988a, b; Striem et al.…”

“…, 2005). In vertebrates, although cAMP mediates sugar perception (Avenet et al. , 1988a, b), the Gq/phospholipase C and gustducine/phosphodiesterase pathway (McLaughlin et al.…”

“…, 2002). The AC/cAMP pathway is already known to participate in various physiological signaling, including sugar‐taste perception in vertebrates (Avenet et al. , 1988a, b; Striem et al.…”

Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells

“…Regulation of L‐type (especially Ca v 1.2), but not P/Q‐type, channels by PKA phosphorylation is well documented in cardiac and skeletal muscle, neurons, and chromaffin cells (reviewed in McDonald et al 1994). In patch‐clamp recordings, some cells in frog and rat taste buds are strongly depolarized by cAMP elevation, an effect attributed to PKA‐mediated block of a K + current (Tonosaki & Funakoshi, 1988; Avenet et al 1988; Cummings et al 1993, 1996). In intact tongue preparations, membrane‐permeant cAMP analogues produce bursts of action potentials in taste buds and/or afferent nerves (Cummings et al 1993).…”

Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster

“…Thus, we have identified, for the first time, the specific AC in sugar perception in Drosophila . In vertebrates, it has already been reported that the cAMP mediating pathway is involved in sugar perception (Avenet et al. , 1988a, b; Striem et al.…”

“…, 2005). In vertebrates, although cAMP mediates sugar perception (Avenet et al. , 1988a, b), the Gq/phospholipase C and gustducine/phosphodiesterase pathway (McLaughlin et al.…”

“…, 2002). The AC/cAMP pathway is already known to participate in various physiological signaling, including sugar‐taste perception in vertebrates (Avenet et al. , 1988a, b; Striem et al.…”