2016
DOI: 10.1007/s11302-016-9551-2
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Abstract: Inosine is a purine nucleoside formed by the breakdown of adenosine that elicits an antidepressant-like effect in mice through activation of adenosine A 1 and A 2A receptors. However, the signaling pathways underlying this effect are largely unknown. To address this issue, the present study investigated the influence of extracellular-regulated protein kinase (ERK)1/2, Ca 2+ /calmoduline-dependent protein kinase (CaMKII), protein kinase A (PKA), phosphoinositide 3-kinase (PI3K)/Akt, and glycogen synthase kinase… Show more

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Cited by 29 publications
(19 citation statements)
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References 85 publications
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“…Interestingly the discrimination based on the diagnostic performance of inosine for the DN-MDD group (AUC = 0.999) was different from that for the DT-MDD (AUC = 0.866). This was consistent with a previous study that reported that oral administration of inosine has antidepressant-like effects in animal models [40, 41]. According to our multiple regression analysis, we conclude that the plasma inosine levels are negatively correlated with depression symptoms severity, and that boys have lower inosine level than girls, which may result from the antioxidant effect of female hormones reducing the demand of uric acid in girls [42].…”
Section: Discussionsupporting
confidence: 92%
“…Interestingly the discrimination based on the diagnostic performance of inosine for the DN-MDD group (AUC = 0.999) was different from that for the DT-MDD (AUC = 0.866). This was consistent with a previous study that reported that oral administration of inosine has antidepressant-like effects in animal models [40, 41]. According to our multiple regression analysis, we conclude that the plasma inosine levels are negatively correlated with depression symptoms severity, and that boys have lower inosine level than girls, which may result from the antioxidant effect of female hormones reducing the demand of uric acid in girls [42].…”
Section: Discussionsupporting
confidence: 92%
“…In addition, a significant increase of XO activity in the thalamus and the putamen of patients with recurrent depression have been found [84]. Potential antidepressant actions of inosine have been shown in several preclinical studies [85][86][87][88]. Kaster and colleagues [86] showed that mice treated with inosine had higher anti-immobility effects in the forced swim and in the tail suspension tests.…”
Section: Purinergic Metabolism and Biomarkersmentioning
confidence: 98%
“…A 1 R agonists have been used to treat anxiety, but have troublesome side-effects so positive allosteric modulators have been developed as potent anxiolytic agents ( Vincenzi et al, 2016 ). An antidepressant-like effect of inosine in mice has been reported ( Gonçalves et al, 2017 ).…”
Section: Disorders Of the Central Nervous System (Cns)mentioning
confidence: 99%