Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases

Lai, Hsiang-Chun; Chang, Qwang Yuen; Hsieh, Ching-Liang

doi:10.1155/2019/2909632

Cited by 29 publications

(28 citation statements)

References 167 publications

(165 reference statements)

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“…According to TCM theory, the three acupoints are located at very important sites of the body. They have roles in the regulation of various metabolic activities, including gastrointestinal motility, glandular secretion and nerve conduction[ 9 , 10 , 14 , 16 ]. We therefore hypothesized that, in addition to local effects, acupuncture on ST36, KI1 and CV4 can also improve the conditions of NAFLD by regulating systemic metabolism.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Guo

Meng

et al. 2020

WJG

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BACKGROUND Non-alcoholic fatty liver disease (NAFLD), in which abnormal lipid metabolism plays an important role in disease progression, has become a pandemic. Abnormal lipid metabolism, for example an increased fat intake, has been thought to be an initial factor leading to NAFLD. The small intestine is the main site of dietary lipid absorption. A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism, which is closely associated with the progression of NAFLD. We therefore hypothesized that, acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of lipid. AIM To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse model. METHODS 8-wk-old male C57BL/6J mice were fed a methionine- and choline-deficient diet for 3 wk. Then, all mice were separated randomly into acupoints group (AG) or non-acupoints group (NG) with high fat diet feeding. Needling treatment was performed at Zu san li, Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG mice. Finally, mice were anesthetized with an injection of ketamine-medetomidine and euthanized by exsanguination. RESULTS An apparent improvement of obesity was found in AG mice after acupuncture treatment. In AG mice, the body weight was much lower (22.6 ± 1.2 g vs 28.1 ± 1.0 g, P < 0.005) in comparison to NG mice. The length of small intestine in AG mice was significantly shorter (26.7 ± 2.3 cm vs 32.7 ± 2.7 cm, P < 0.005). A large amount of chyme was observed in the lumen of the AG small intestine. The expression of microsomal triglyceride transfer protein, apolipoprotein B and apolipoprotein C2 was downregulated. Triacylglycerols (TGs), total cholesterol and nonesterified fatty acid (NEFA) levels of the small intestinal tissue were significantly higher in AG mice, but the serum TGs and NEFA levels were reduced in AG mice. CONCLUSION These results indicate that acupuncture at Zu san li, Guan yuan and Yong quan suppressed lipid absorption by downregulating the expression of apolipoproteins in the small intestine.

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Section: Introductionmentioning

confidence: 99%

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Guo

Meng

et al. 2020

WJG

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“…acupuncture, have been reported to be effective for treating numerous nervous system disorders by affecting synaptic plasticity, elevating neurotrophic factors, offering neuroprotection, fostering maintenance of the blood-brain barrier, and inducing cell proliferation, antioxidant activity, antiinflammatory and anti-apoptosis effects [15,16]. Low-intensity laser therapy has been used in neurorehabilitation and in cases of cognitive dysfunction and traumatic brain injury [17,18].…”

Section: Methodsmentioning

confidence: 99%

“…The mechanism of acupuncture therapy for cerebral ischemia includes improving the brain flows, inhibiting oxidative stress and inflammation, restoring the blood-brain barrier, promoting angiogenesis [14]. Electroacupuncture (EA), a combination of modern electric stimulation and acupuncture, have been reported to be effective for treating numerous nervous system disorders by affecting synaptic plasticity, elevating neurotrophic factors, offering neuroprotection, fostering maintenance of the blood-brain barrier, and inducing cell proliferation, antioxidant activity, anti-inflammatory and anti-apoptosis effects [15,16]. Low-intensity laser therapy has been used in neurorehabilitation and in cases of cognitive dysfunction and traumatic brain injury [17,18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Chen

Hsieh

2020

Antioxidants

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In this article, we review how acupuncture regulates oxidative stress to prevent ischemia–reperfusion injury. We electronically searched databases, including PubMed, Clinical Key and the Cochrane Library, from their inception to November 2019 by using the following medical subject headings and keywords: acupuncture, ischemia-reperfusion injury, oxidative stress, reactive oxygen species, and antioxidants. We concluded that acupuncture is effective in treating oxidation after ischemia-reperfusion injury. In addition to increasing the activity of antioxidant enzymes and downregulating the generation of reactive oxygen species (ROS), acupuncture also repairs the DNA, lipids, and proteins attacked by ROS and mediates downstream of the ROS pathway to apoptosis.

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“…Other studies also report that the antidepressant effect of acupuncture is significant and has a multitarget characteristic [53]. Acupuncture treats nervous system diseases by increasing the brain-derived neurotrophic factor level and involving multiple signal pathways, which may be related to amino acid metabolism and inflammatory pathways, especially the toll-like receptor signaling pathway [54].…”

Section: Subtotal (95% Ci)mentioning

confidence: 99%

Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Xiao

Zhang

Yao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To determine the effectiveness and safety of acupuncture for perimenopausal depression. Methods. We searched the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, CNKI, VIP Citation Databases, Wan Fang, and online trial registries such as ClinicalTrials.gov for randomized controlled trials (RCTs) assessing the efficacy and safety of acupuncture for perimenopausal depression. Literature screening, data extraction, and determination of the risk of bias were performed by two researchers independently. The extracted data were pooled and meta-analyzed using RevMan5.3 software. Results. In total, 16 RCTs covering 1311 patients were enrolled. Overall, the results showed that acupuncture was more effective in the treatment of perimenopausal depression than antidepressants (OR = 2.68, 95% CI (1.84, 3.90), P<0.00001). Furthermore, HAMD scores in the manual acupuncture group and electroacupuncture group were lower than those of antidepressants (manual acupuncture vs. antidepressants (MD = −2.35, 95% CI (−2.93, −1.77), P<0.00001) and electroacupuncture vs. antidepressants (MD = −1.2, 95% CI (−1.92, −0.48), P=0.001)). Data analysis revealed that the treatment effect of acupuncture was more stable than that of antidepressants (MD = −2.4, 95% CI (−3.37, −1.43), P<0.00001). Moreover, acupuncture was safer than antidepressants based on the incidence of adverse events (OR = 0.23, 95% CI (0.1, 0.52), P=0.0004). But acupuncture has no effect on estrogen levels (P≥0.05). Conclusions. Acupuncture for perimenopausal depression is safe and effective. Moreover, it has more stable long-term effects than antidepressants and hormone replacement therapy (HRT). We recommend acupuncture as a clinical treatment of perimenopausal depression.

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Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases

Cited by 29 publications

References 167 publications

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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