1998
DOI: 10.1161/01.hyp.32.2.338
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Abstract: Abstract-The vascular wall is constantly subjected to a variety of mechanical forces in the form of stretch (tensile stress), due to blood pressure, and shear stress, due to blood flow. Alterations in either of these stresses are known to result in vascular remodeling, an adaptation characterized by modified morphology and function of the blood vessels, allowing the vessels to cope with physiological or pathological conditions. The processes involved in vascular remodeling include cellular hypertrophy and hype… Show more

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Cited by 266 publications
(196 citation statements)
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“…If FAK is involved in volume-sensitive PLC␥ activation, our observations would suggest that focal adhesions may not be the sole site of the swelling-activated interaction between these two proteins because the bulk of plasma membrane-bound tyrosinephosphorylated PLC␥, as detected by immunofluorescence, did not appear to be present in focal adhesions during times corresponding to maximal swelling-induced tyrosine phosphorylation of PLC␥ as determined by immunoblot analysis. Members of the Src family of tyrosine kinases, which can associate with PI 3-kinase (29) as well as FAK (30), mediate volume recovery from swelling in lymphocytes (31) and play important roles in mechanotransduction (32). In lung, mechanical strain elicits Src-mediated PLC␥ activation as a consequence of rearrangements of the actin cytoskeleton (33).…”
Section: Discussionmentioning
confidence: 99%
“…If FAK is involved in volume-sensitive PLC␥ activation, our observations would suggest that focal adhesions may not be the sole site of the swelling-activated interaction between these two proteins because the bulk of plasma membrane-bound tyrosinephosphorylated PLC␥, as detected by immunofluorescence, did not appear to be present in focal adhesions during times corresponding to maximal swelling-induced tyrosine phosphorylation of PLC␥ as determined by immunoblot analysis. Members of the Src family of tyrosine kinases, which can associate with PI 3-kinase (29) as well as FAK (30), mediate volume recovery from swelling in lymphocytes (31) and play important roles in mechanotransduction (32). In lung, mechanical strain elicits Src-mediated PLC␥ activation as a consequence of rearrangements of the actin cytoskeleton (33).…”
Section: Discussionmentioning
confidence: 99%
“…39 The extracellular matrix cannot be involved in the modifications described in the present study because the same cell substrate, collagentype 1, was used in all experiments. Several soluble factors present in the serum may also control gene expression.…”
Section: Discussionmentioning
confidence: 99%
“…Cell-cell interaction is certainly an important factor because redifferentiation occurs when cells are confluent and are kept in high-density cultures. The absence of pressure and flow 39 and the absence of the endothelial cell lining may also be important factors in the dedifferentiation process. Additional experiments are now needed to define the factors involved in the regulation of SERCA2, RyR, and IP3R gene expression in vascular smooth muscle cells.…”
Section: Discussionmentioning
confidence: 99%
“…In another study, mechanical strain applied to SMCs grown on laminin caused a greater increase in h-caldesmon when com- pared with SMCs grown on collagen type I or IV. 58 The signal transduction pathways that are activated by stretch and shear stress 59 have also been shown to increase expression of SM-MHC. 60 Similar to the various effects reported on SMC marker gene expression, conflicting data exist on the growth response of SMCs to mechanical strain in culture.…”
Section: Physical Factorsmentioning
confidence: 99%