Signal transducer and activator of transcription 3 signaling in tumor immune evasion

Zhang, Luying; Kuča, Kamil; Li, You; Zhao, Yingying; Musílek, Kamil; Nepovimová, Eugenie; Wu, Qinghua; Wu, Weijie; Adam, Vojtěch

doi:10.1016/j.pharmthera.2021.107969

Cited by 38 publications

(32 citation statements)

References 97 publications

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“…STAT3 has been shown to bind to the PD-L1 promoter to regulate its expression in a transcriptional manner, 36 which could induce apoptosis of immune cells, inhibit the lethality of T cells and promote tumour immune escape. 37 In addition, we verified the relationship between MIAT, miR-411-5p, STAT3 and PD-L1 in HCC specimens. In summary, we found that MIAT in HCC cells can promote the expression of STAT3 and PD-L1 through sponging of miR-411-5p.…”

Section: Discussionmentioning

confidence: 59%

“…The luciferase report experiment and RIP results show that MIAT and STAT3 can directly bind to miR‐411‐5p. STAT3 has been shown to bind to the PD‐L1 promoter to regulate its expression in a transcriptional manner, 36 which could induce apoptosis of immune cells, inhibit the lethality of T cells and promote tumour immune escape 37 . In addition, we verified the relationship between MIAT, miR‐411‐5p, STAT3 and PD‐L1 in HCC specimens.…”

Section: Discussionmentioning

confidence: 61%

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lncRNA MIAT targets miR‐411‐5p/STAT3/PD‐L1 axis mediating hepatocellular carcinoma immune response

Zhang

Pan

Qiu

et al. 2022

Int J Experimental Path

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Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death in the world. 1 In September 2017, with the development of immunotherapy, Food and Drug Administration (FDA) approved anti-PD-1 antibody nivolumab as a second-line treatment scheme for patients with advanced HCC who had previously been treated with sorafenib 2 and achieved good curative effect, while more patients who received checkpoint blocker therapy could not achieve the ideal results. 3 Therefore, exploring the reasons for the poor efficacy of immune checkpoint therapy has become a hot spot in clinical HCC treatment. The discovery of novel intervention targets

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 61%

lncRNA MIAT targets miR‐411‐5p/STAT3/PD‐L1 axis mediating hepatocellular carcinoma immune response

Zhang

Pan

Qiu

et al. 2022

Int J Experimental Path

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“… 11 Indeed, STAT3 is involved in immune cell evasion aiding tumor progression and metastasis. 12 Similarly, PD-L1 expression has also been reported in different brain stromal cells with immunosuppressive consequences, such as reactive astrocytes, 11 microglial cells 13 or infiltrating peripheral neutrophils. 14 …”

Section: Introductionmentioning

confidence: 95%

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

et al. 2022

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Nearly 40% of the advanced cancer patients will present brain metastases during the course of their disease, with a 2-year life expectancy of less than 10%. Immune system impairment, including the modulation of both STAT3 and PD-L1, is one of the hallmarks of brain metastases. Liquid biopsy could offer several advantages in brain metastases management, such as the possibility of noninvasive dynamic monitoring. Extracellular vesicles (EVs) have been recently proposed as novel biomarkers especially useful in liquid biopsy due to their secretion in biofluids and their role in cell communication during tumor progression. The main aim of this work was to characterize the size and protein cargo of plasma circulating EVs in patients with solid tumors and their correlation with newly diagnosed brain metastases, in addition to their association with other relevant clinical variables. We analyzed circulating EVs in the plasma of 123 patients: 42 patients with brain metastases, 50 without brain metastases and 31 healthy controls. Patients with newly diagnosed brain metastases had a lower number of circulating EVs in the plasma and a higher protein concentration in small EVs (sEVs) compared to patients without brain metastases and healthy controls. Interestingly, melanoma patients with brain metastases presented decreased STAT3 activation and increased PD-L1 levels in circulating sEVs compared to patients without central nervous system metastases. Decreased STAT3 activation and increased PD-L1 in plasma circulating sEVs identify melanoma patients with brain metastasis.

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“…Due to the high encapsulation efficiency and controllable drug release ability, the PDA nanosystem therefore shows broad application potentials by combining chemotherapy and PTT for antitumor treatment ( Wang et al, 2018 ). The insufficient heat damage induced by PTT cannot always completely eradicate tumor cells due to the presence of multiple intracellular defense mechanisms in cancer cells, especially “autophagy,” which is activated by cancer cells to avert and repair cellular damage caused by PTT ( Amaravadi et al, 2019 ; Zhang et al, 2022 ). Autophagy is a self-degradation process that maintains cellular homeostasis through degradation of misfolded proteins or damaged organelles by the lysosomal system ( Choi et al, 2013 ).…”

Section: Functions Of Pda Nanosystem Mediated Pttmentioning

confidence: 99%

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

et al. 2022

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Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.

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Signal transducer and activator of transcription 3 signaling in tumor immune evasion

Cited by 38 publications

References 97 publications

lncRNA MIAT targets miR‐411‐5p/STAT3/PD‐L1 axis mediating hepatocellular carcinoma immune response

lncRNA MIAT targets miR‐411‐5p/STAT3/PD‐L1 axis mediating hepatocellular carcinoma immune response

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

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