Signal integration during development: Insights from the <i>Drosophila</i> eye

Voas, Matthew G.; Rebay, Ilaria

doi:10.1002/dvdy.10449

Cited by 162 publications

(164 citation statements)

References 117 publications

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“…It has been implicated in a number of developmental processes in Drosophila (reviewed in ref. 45) but so far not in hematopoiesis or hemocyte function. It is possible that ectopic expression of Egfr may mimic, in part, the effect of other receptor tyrosine kinases that are normally present in the hemocytes, such as Pvr or perhaps Alk.…”

Section: Discussionmentioning

confidence: 99%

A directed screen for genes involved in Drosophila blood cell activation

Zettervall

Ines

Williams

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

324

400

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An attack by a parasitic wasp activates a vigorous cellular immune response in Drosophila larvae. This response is manifested by an increased number of circulating cells, the hemocytes, and by the appearance of a specialized class of hemocyte, the lamellocytes, which participate in the encapsulation and killing of the parasite. To study the molecular mechanisms of this response, we have overexpressed different genes in the hemocytes, by using the GAL4-upstream activating sequence system and a hemocytespecific Hemese-GAL4 driver. Multiple transgenes were tested, representing several important signaling pathways. We found that the proliferation response and the activation of lamellocyte formation are independent phenomena. A drastic increase in the number of circulating hemocytes is caused by receptor tyrosine kinases, such as Egfr, Pvr, and Alk, as well as by the downstream signaling components Ras85D and pointed, supporting the notion that the Ras-mitogen-activated protein kinase pathway regulates hemocyte numbers. In the case of Pvr and Alk, this phenotype also is accompanied by lamellocyte formation. By contrast, constitutively active hopscotch and hemipterous give massive activation of lamellocyte formation with little or no increase in total hemocyte numbers. This finding indicates that both the Jak͞Stat and the Jun kinase pathways affect lamellocyte formation. Still other signals, mediated by aop ACT , Toll 10b , and Rac1 expression, cause a simultaneous increase in lamellocyte and total cell numbers, and the same effect is seen when WNT signaling is suppressed. We conclude that the activation of a cellular response is complex and affected by multiple signaling pathways.

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Section: Discussionmentioning

confidence: 99%

A directed screen for genes involved in Drosophila blood cell activation

Zettervall

Ines

Williams

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

324

400

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“…Groucho integrates RTK signalling with multiple pathways RTK pathways have frequently been shown to interact with other signal transduction pathways, consistent with extensive dialogues taking place between signalling cascades, yet the precise level(s) at which these pathways interconnect have remained largely elusive (Voas and Rebay, 2004). In a like manner to the case of the N and EGFR pathways, Gro/TLE could be a focal point between RTKs and other pathways.…”

Section: Switching Between Modes Of Transcriptional Regulationmentioning

confidence: 91%

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

Hasson

Paroush

2006

Br J Cancer

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“…However, they act redundantly with an intercellular signal that is used reiteratively to instruct all cell fates in the eye. Signals mediated through the EGF Receptor (EGFR) and Ras transduction pathway are critical for eye development [10]. Although knockout of either EGFR or the transduction pathway have no effect on PP determination, loss of Eya/So and EGFR signaling together blocks PP determination [9].…”

Section: Primary Pigment Cell Determinationmentioning

confidence: 99%

Pattern formation in the Drosophila eye

Carthew

2007

Current Opinion in Genetics & Development

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The insect compound eye is one of the most precise and highly ordered patterns in the living world. It develops from an unpatterned simple epithelium by a series of cell fate decisions and complex morphogenetic movements. In the first days of metamorphosis, this interplay is particularly noticeable. Recent insights have revealed how interactions between neighboring cells drive the process. Interaction between Delta on cone cells and Notch proteins on the surface of neighbors induces the first pigment cells to differentiate. The primary pigment cells then express a Nephrin protein, Hibris, that interacts with a different Nephrin, Roughest, on their neighbors. Heterophilic adhesion between Hibris and Roughest result in remodeling contacts between cells to favour their contact with the pigment cells. In conjunction, the primary pigment cells signal to neighbors through the EGF Receptor to survive rather than undergo apoptosis. This sorting and culling process results in a sculpted pattern with a precise number and position of cells that is repeated hundreds of times in each compound eye.

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Signal integration during development: Insights from the Drosophila eye

Cited by 162 publications

References 117 publications

A directed screen for genes involved in Drosophila blood cell activation

A directed screen for genes involved in Drosophila blood cell activation

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

Pattern formation in the Drosophila eye

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