Sign of Leser–Trélat

Case report of Leser-Trelat sign as sequela of an atypical inflammatory process

“…Leser-Trelat sign is a rare cutaneous manifestation that is usually related to gastrointestinal malignancies [1] . The most common association is gastric adenocarcinoma, but other gastrointestinal tract malignancies, prostate cancer, and lymphomas have also been reported [2] . Nonetheless, in a minority of cases, a malignant process is not found, thus LTS is referred to as pseudo-leser-trelat sign [3] .…”

“…Leser-Trelat sign (LTS) is a rare paraneoplastic syndrome, in which an abrupt eruption of multiple seborrheic keratosis occurs throughout different areas of the body, most notably the chest and back [2] . LTS has been related to young otherwise healthy individuals who harvest a gastrointestinal malignancy, most commonly gastric adenocarcinoma [2] . To date, have been no standardized criteria for the diagnosis of LTS in association to malignancy [1] .…”

“…A relationship with the appearance of a benign neoplasm has not been described in the literature. It is thought that LTS can be caused by paraneoplastic syndrome, where a cascade of cytokines and growth factors are released by malignant neoplasms [2] . In this case report, we describe an adult man that presents an abrupt onset of seborrheic keratosis and a large intra-abdominal tumor, highly suspected for malignancy.…”

Sign of Leser-Trélat and Cutaneous T-Cell Lymphoma: A Rare Association

“…Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link [ 2 ]. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer [ 1 , 3 , 4 ]. In our case, unfortunately the patient refused the intestinal endoscopy but the CT scan was normal.…”

Leser-Trélat-Syndrom assoziiert mit malignem Melanom

“…Es besteht jedoch der Verdacht, dass die Freisetzung von Zytokinen und Wachstumsfaktoren aus der Neoplasie das eruptive Wachstum der seborrhoischen Keratosen stimuliert. Insbesondere die Überexpression von EGFR (Rezeptor für epidermalen Wachstumsfaktor) kann zum Ausbruch dieser Läsionen beitragen [5]. Normalerweise sind die Rezeptoren für epidermalen Wachstumsfaktor (EGFR) auf den basalen Keratinozyten vorhanden und nehmen an Anzahl ab im Verlauf der Differenzierung der Keratinozyten in oberen Epidermisschichten.…”