Side Effects Associated with Prostaglandin Analog Therapy

Alm, Albert; Grierson, Ian; Shields, M. Bruce

doi:10.1016/j.survophthal.2008.08.004

Cited by 239 publications

(185 citation statements)

References 126 publications

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“…Although conjunctival hyperaemia, eyelash changes, and increased pigmentation of periocular skin (removed by epidermal exfoliation) are reversible, increase of iris pigmentation, caused by an increase of the size of melanin granules in iris melanocytes, is considered irreversible. 19,20 In our case also this event regressed; however, increase of iris pigmentation has been shown with no ocular damage.…”

Section: Discussionsupporting

confidence: 59%

Long-term efficacy of latanoprost in primary congenital glaucoma

Uva

Avitabile

Reibaldi

et al. 2013

Eye

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Purpose To investigate the success (glaucoma control) of latanoprost therapy of primary congenital glaucoma (PCG) and factors affecting the long-term outcome. Methods Patients with PCG treated with latanoprost were re-examined. At study visit and from clinical charts, we evaluated: intraocular pressure, length of glaucoma control with latanoprost, need of further medication or glaucoma surgery, systemic and topical side effects. Multivariate analysis was used to test factors related to the final outcome of the treatment.Results Eighty-one eyes of 44 patients with PCG, and 42 eyes of 29 patients with previous glaucoma surgery, had received latanoprost therapy. In the first group, a success (glaucoma control by latanoprost therapy) was found in 24 eyes (29.6%), whereas 57 eyes (70.4%) had received surgery (45 eyes (55.6%) in the first year); among the eyes with previous surgery, a success was found in 12 eyes (28.6%), 13 eyes (31%) required an additional therapy, and 17 eyes (40.5%) had received further glaucoma surgery. No patient discontinued the treatment because of side effects. Factors related to the failure of the latanoprost treatment were: the high score of severity of glaucoma (P ¼ 0.014) and low age at PCG presentation (P ¼ 0.042). Conclusions Long-term treatment with latanoprost is effective in about 30% of the eyes; factors related to failure were severe glaucomatous alterations, and young age at PCG presentation.

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Section: Discussionsupporting

confidence: 59%

Long-term efficacy of latanoprost in primary congenital glaucoma

Uva

Avitabile

Reibaldi

et al. 2013

Eye

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“…The reported ocular complications with latanoprost include conjunctival hyperemia, iris discoloration, anterior uveitis and cystoid macular edema (CME) iris cysts, and reactivation of herpes simplex keratitis. 3 Although a few studies showing an association between serous macular detachment and CME with latanoprost have been published, there are no previous reports that indicate the possible relationship between latanoprost treatment and CSC. To the best of our knowledge, this is the first case of a patient who developed CSC as a possible complication of latanoprost treatment.…”

mentioning

confidence: 99%

“…2 Prostaglandin analogues reduce IOP by enhancing uveoscleral outflow and may also have some effect on vascular permeability as well. 3 Prostaglandins, which are metabolic products of arachidonic acid, are the most extensively studied chemical transmitters contributing to general edema in systemic tissues, including eye tissue. It has been suggested that prostaglandins can mimic vascular endothelial growth factor (VEgF) and vascular permeability factor (VPF), inducing vascular permeability.…”

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confidence: 99%

Central Serous Chorioretinopathy Associated with Topical Latanoprost Therapy

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et al. 2011

Ocular Immunology and Inflammation

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“…8 Çeşitli çalışmalarla prostaglandinlerin hem tirozinaz gen transkripsiyonunu arttırarak hem de direkt tirozinaz enzim aktivitesini arttırarak melanogenezi arttırdığı, bunun da muhtemelen prostanoid reseptör uyarımı yolu ile olduğu gösterilmiştir. 2,8,[17][18][19][20] Elektron mikroskopisi ile yapılan çalışmalarda immatür melanozom ya da matür melanin granüllerinin sayısında değişiklik olmadan var olan melanin granüllerinin boyutunun arttığı gösterilmiştir. 8 PGA ilişkili iris hiperpigmentasyonu çoğunlukla tedavinin bitmesine rağmen düzelme göstermez veya çok yavaş gerileme gösterir.…”

Section: Pga-i̇ris Hiperpigmentasyonuunclassified

Topikal Prostaglandin Analogları ve Hiperpigmentasyon

Duman¹

2016

J Contemp Med

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Topical prostaglandin analogues are among commonly used glaucoma medications. These are considerably safe drugs, however they have some local adverse effects such as conjunctival hyperemia, iris hyperpigmentation, elongation and darkening of eyelashes, and periocular skin hyperpigmentation. The aim of the present article is to review available literature data on topical prostaglandin analogue-induced hyperpigmentation of iris, eyelash and periocular skin and to evaluate the clinical features, possible etiopathogenetic mechanisms, and clinical outcomes.

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Side Effects Associated with Prostaglandin Analog Therapy

Cited by 239 publications

References 126 publications

Long-term efficacy of latanoprost in primary congenital glaucoma

Long-term efficacy of latanoprost in primary congenital glaucoma

Central Serous Chorioretinopathy Associated with Topical Latanoprost Therapy

Topikal Prostaglandin Analogları ve Hiperpigmentasyon

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