1987
DOI: 10.1001/archderm.123.4.482
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Sickle cell leg ulcers are associated with HLA-B35 and Cw4

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Cited by 8 publications
(13 citation statements)
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“…Furthermore, the same group of genes was found associated with increased susceptibility to venous leg ulcer in older subjects who do not have SCD [14,21].…”
Section: Genome-wide Association Studymentioning
confidence: 71%
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“…Furthermore, the same group of genes was found associated with increased susceptibility to venous leg ulcer in older subjects who do not have SCD [14,21].…”
Section: Genome-wide Association Studymentioning
confidence: 71%
“…A small study of 9 cases and 29 controls showed possible associations of HLA-B35 and CW14 alleles: the study showed that carriers of both alleles increase the risk for the complication by 17 fold [14]. This study however was very small, and the region identified is very difficult to study because of the long range linkage disequilibrium.…”
Section: Candidate Gene Studiesmentioning
confidence: 85%
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“…Several factors influence the development of SCA complications, including human leukocyte antigen (HLA) genotypes (13)(14)(15)(16)(17). The contribution of HLA class I (16) and class II (13,18) polymorphisms to SCA osteomyelitis and other complications were previously investigated with inconsistent results.…”
mentioning
confidence: 99%
“…In spite of this uniform genotype, there is phenotypic heterogeneity and the associated factors (environmental or genetic) are still to be elucidated. Several studies have shown that immunogenetics, especially HLA types, play a significant role in SCD [11][12][13][14], just as they do in other vascular diseases characterized by blood cellular interactions with the endothelium [15][16][17] [12,14]. We are, however, not aware of any previous studies of HLA allele association studies with AVN in SCD.…”
Section: Introductionmentioning
confidence: 97%