Sialolithiasis: mineralogical composition, crystalline structure, calculus site, and epidemiological features

Barrueco, Álvaro Sánchez; Cornejo, María Victoria López-Acevedo; Rueda, Ignacio Alcalá; Andrés, Sol López; Galán, Fernando González; Tapia, Gonzalo Díaz; Mahíllo‐Fernández, Ignacio; Español, Carlos Cenjor; Aubá, José Miguel Villacampa

doi:10.1016/j.bjoms.2022.08.005

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the intermediate layers on points 02, 03, and 04, dense hydroxyapatite aggregates are observed with bacterial empty casts (blue arrowheads) at 20,000× magnification. Point 05 Points 08 and 14 depict a densely aggregated layer of microscopic mineral masses compatible with octacalcium phosphate 24 . A filament pattern of the inorganic matter compatible with carbonate apatite arranged in different orientations was observed on point 10 (red arrowheads).…”

Section: Sialolith Specimen Datamentioning

confidence: 99%

“…Points 03, 04, 07 and 08 at the surface of the core show mineral masses compatible with octacalcium phosphate. At the core of the sialolith a hexahedral calcite crystal having a mineral composition compatible with whitlockite (blue arrowhead) is observed in a long rod-shaped bacterial mold on point 05 24 . At the core of the sialolith, less dense hydroxyapatite aggregates are observed on point 06 (Suppl.…”

Section: Sialolith Specimen Datamentioning

confidence: 99%

“…Sialolithiasis is a common disease of salivary glands characterized by the obstruction of the salivary secretion by a calculus. The incidence of sialolithiasis is reported to be 0.115%, 23 cases were found among 20,000 patients during 18 years in a stomatologic institute by de Temiño and Villar y Pérez de los Ríos 1 – 3 . The diagnosis is based on the medical history, clinical findings, physical examination, and diagnostic imaging including sialography, ultrasonography, computed tomography (CT), and magnetic resonance imaging 4 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of biological components for sialolith formation organized in circular multi-layers

Sodnom-Ish

Cho

et al. 2023

Sci Rep

View full text Add to dashboard Cite

According to the previous studies of sialolithiasis reported so far, this study is aimed to identify the biological components of sialolith, which show different ultrastructures and chemical compositions from other stones, cholelith and urolith. Twenty-two specimens obtained from 20 patients were examined histologically, and analyzed with micro-CT, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). All sialoliths (n = 22) observed in this study showed a central nidus, which was filled with organoid matrix admixed with exosome vesicles, loose calcium apatite crystals, and many bacteria. The micro-CT and SEM observation clearly defined a single or multiple central nidus(es) encircled by highly calcified compact zone. The circular compact zone showed a band-like calcification, about 1–3 mm in thickness, and usually located between the central nidus and the peripheral multilayer zone. But some sialoliths (n = 5) showed severe erosion of compact zone by expanding multilayered zone depending on the level of calcification and inflammation in sialolith. By observing TEM images, many exosome vesicles and degraded cytoplasmic organelles were found in the central nidus, and some epithelial cells were also found in the calcified matrix of peripheral multilayer zone. Particularly, EDS analysis indicated the highest Ca/P ratio in the intermediate compact zone (1.77), and followed by the central nidus area (1.39) and the peripheral multilayer zone (0.87). Taken together, these data suggest that the central nidus containing many inflammatory exosomes and degraded cytoplasmic organelles has a potential to induce a band-like calcification of compact zone, and followed by the additional multilayer deposition of exfoliated salivary epithelial cells as well as salivary materials. Thereby, the calcium apatite-based sialolith is gradually growing in its volume size, and eventually obstructs the salivary flow and provides a site for the bacterial infection.

show abstract

Section: Sialolith Specimen Datamentioning

confidence: 99%

Section: Sialolith Specimen Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of biological components for sialolith formation organized in circular multi-layers

Sodnom-Ish

Cho

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

Characteristics of sialolithiasis in Israel, a big‐data retrospective study of 5100 cases

Jonas,

Muchnik,

Rabinovich

et al. 2024

Oral Diseases

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to identify risk factors for sialolithiasis patients using a large community and hospital‐based cohort.MethodsA retrospective case–control study was conducted on 20,396 individuals, including 5100 sialolithiasis patients and 15,296 matched controls. Demographics and laboratory data were obtained from electronic medical records. Statistical analyses were performed to identify significant differences between the two groups. A p‐value of <0.05 was considered significant.ResultsSialolithiasis was more prevalent in women, with a mean age at diagnosis of 55.75 years. Several geographic location variables emerged as risk factors for sialolithiasis including Israeli birth, higher socioeconomic communities, and specific areas of residency. Tobacco smoking (odds ratio = 1.46) was a significant risk factor. Low high‐density lipoprotein levels, elevated triglycerides, and elevated amylase levels were associated with sialolithiasis.ConclusionsThis study provides valuable insights into the demographic and laboratory characteristics of sialolithiasis patients, indicating that area of residency and lifestyle factors contribute to the risk of developing sialolithiasis. The findings may contribute to a better understanding of the disease and the development of preventative measures or early diagnostics tools.

show abstract

The Biomineralization Conundrum of Calcified Extraradicular Deposits on the Apical Root Surface of Teeth: A Case Report

Álvarez-Vásquez

2023

TODENTJ

View full text Add to dashboard Cite

Background: Calcified extraradicular deposits on the apical root surface of teeth (CEDARST) are rarely seen in the dental field, compared with dental calculus deposits, which are very frequent. However, the exact biomineralization process of this entity has remained unclear until now. Objective: To report a case of an exuberant calcified extraradicular deposit on the apical root surface of an anterior tooth with apical periodontitis and propose for the first time some potential mechanisms involved in this pathological mineralization, and thereby suggest directions for future research. Case Presentation: In brief, a root-canal-treated canine displaying a radiographic periapical radiolucency was treated, and the sinus tract persisted despite root canal retreatment in which high endodontic standards were maintained. Endodontic surgery was performed, and the curettage of the pathologic tissue revealed an exuberant calculus-like material attached to the outer root surface, around the exit of the apical foramen. Two-year follow-up radiography revealed complete bone healing, and the patient´s tooth was asymptomatic and functional. Conclusion: The development of CEDARST seems to depend on a fine synergic control exerted by specific microorganisms (mainly bacteria) on this pathological mineralization, as well as on the local chemical microenvironment of the apical lesion of the affected tooth. Microbial implications and inhibitors of mineralization seem to play a dominant role in CEDARST biomineralization.

show abstract

Sialolithiasis: mineralogical composition, crystalline structure, calculus site, and epidemiological features

Cited by 3 publications

References 19 publications

Identification of biological components for sialolith formation organized in circular multi-layers

Identification of biological components for sialolith formation organized in circular multi-layers

Characteristics of sialolithiasis in Israel, a big‐data retrospective study of 5100 cases

The Biomineralization Conundrum of Calcified Extraradicular Deposits on the Apical Root Surface of Teeth: A Case Report

Contact Info

Product

Resources

About