Shortened telomere in unremitted schizophrenia

Kota, Lakshmi Narayanan; Purushottam, Meera; Moily, Nagaraj S.; Jain, Sanjeev

doi:10.1111/pcn.12260

Cited by 36 publications

(31 citation statements)

References 43 publications

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“…Smoking and BMI were not examined as potential confounds. Similarly, Kota et al (In press) reported that “unremitted,” but not “remitted,” schizophrenia was associated with short LTL compared to controls. The three remaining studies failed to detect short LTL in schizophrenia.…”

Section: Telomere Length In Psychiatric Illnessesmentioning

confidence: 96%

“…Seven studies have assessed LTL in schizophrenia or other psychotic disorders (Fernandez-Egea et al, 2009; Kao et al, 2008; Kota et al, In press; Malaspina et al, 2014 Mansour et al, 2011; Nieratschker et al, 2013; Yu et al, 2008) (Table 2). In one study, LTL was significantly shortened in individuals with schizophrenia and was unrelated to antipsychotic use or duration of illness (Kao et al, 2008).…”

Section: Telomere Length In Psychiatric Illnessesmentioning

confidence: 99%

See 1 more Smart Citation

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Lindqvist

Epel

Mellon³

et al. 2015

Neuroscience & Biobehavioral Reviews

269

231

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Many psychiatric illnesses are associated with early mortality and with an increased risk of developing physical diseases that are more typically seen in the elderly. Moreover, certain psychiatric illnesses may be associated with accelerated cellular aging, evidenced by shortened leukocyte telomere length (LTL), which could underlie this association. Shortened LTL reflects a cell's mitotic history and cumulative exposure to inflammation and oxidation as well as the availability of telomerase, a telomere-lengthening enzyme. Critically short telomeres can cause cells to undergo senescence, apoptosis or genomic instability, and shorter LTL correlates with poorer health and predicts mortality. Emerging data suggest that LTL may be reduced in certain psychiatric illnesses, perhaps in proportion to exposure to the psychiatric illnesses, although conflicting data exist. Telomerase has been less well characterized in psychiatric illnesses, but a role in depression and in antidepressant and neurotrophic effects has been suggested by preclinical and clinical studies. In this article, studies on LTL and telomerase activity in psychiatric illnesses are critically reviewed, potential mediators are discussed, and future directions are suggested. A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. DISCLOSURESJL is a consultant to Telomere Diagnostics Inc., formerly Telome Health, and owns stock in the company. The company had no role in this research or in writing this review. The remaining authors report no current disclosures or conflicts of interest. HHS Public Access

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Section: Telomere Length In Psychiatric Illnessesmentioning

confidence: 96%

Section: Telomere Length In Psychiatric Illnessesmentioning

confidence: 99%

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Lindqvist

Epel

Mellon³

et al. 2015

Neuroscience & Biobehavioral Reviews

269

231

View full text Add to dashboard Cite

show abstract

“…Thus far, cross-sectional studies have reported mixed results. Several investigations found shorter LTL in persons with schizophrenia than in healthy comparison subjects (HCs) (Fernandez-Egea et al, 2009;Kao et al, 2008) or at least in subgroups of individuals with more chronic, severely psychotic, or treatment-resistant illness (Kota et al, 2015;Li et al, 2015;Rao et al, 2016;Yu et al, 2008) (but see (Lin, 2015)), possibly suggesting accelerated biological aging Kirkpatrick et al, 2008). However, one large study reported longer LTL in schizophrenia than in HCs (Nieratschker et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Leukocyte telomere length: Effects of schizophrenia, age, and gender

Wolkowitz

Jeste

Martin

et al. 2017

Journal of Psychiatric Research

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a b s t r a c tBackground: Schizophrenia is linked with early medical comorbidity and mortality. These observations indicate possible "accelerated biological aging" in schizophrenia, although prior findings are mixed, and few such studies have examined the role of gender. One putative marker of biological aging is leukocyte telomere length (LTL), which typically shortens with age. Methods: We assessed LTL in phenotypically well characterized 134 individuals with schizophrenia (60 women and 74 men) and 123 healthy comparison subjects (HCs) (66 women and 57 men), aged 26 to 65 years. Results: Overall, LTL was inversely associated with age (t(249) ¼ -6.2, p < 0.001), and a gender effect on the rate of LTL decrease with age was found (t(249) ¼ 2.20, p ¼ 0.029), with men declining more rapidly than women. No significant overall effect of diagnosis on the rate of decline was detected. However, at the average sample age (48 years), there was a significant gender effect in both schizophrenia and HC groups (t(249) ¼ 2.48, p ¼ 0.014), with women having longer LTL than men, and a significant gender X diagnosis effect (t(249) ¼ 2.43, p ¼ 0.016) -at the average sample age, women with schizophrenia had shorter LTL than HC women. Discussion: Gender, not the diagnosis of schizophrenia, was the major factor involved with LTL shortening across the age range studied. We discuss the constraints of a cross-sectional design and other methodological issues, and indicate future directions. Understanding the impact of schizophrenia on biological aging will require separate evaluations in men and women.Published by Elsevier Ltd.

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“…Whether or not schizophrenic patients possess shorter (Kota et al 2014) or longer (Nieratschker et al 2013) telomere length on chromosomes remains at issue, noting that telomere length is regulated by additional factors such as demographics, diet, vitamin levels, etc. (e.g., Cieslak et al 2014;Malaspina et al 2014).…”

Section: Exercise Amelioration Of Telomeric-shorteningmentioning

confidence: 99%

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer

Kostrzewa

2015

Neurotox Res

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Schizophrenia spectrum disorders are characterized by symptom profiles consisting of positive and negative symptoms, cognitive impairment, and a plethora of genetic, epigenetic, and phenotypic biomarkers. Assorted animal models of these disorders and clinical neurodevelopmental indicators have implicated neurodegeneration as an element in the underlying pathophysiology. Physical exercise or activity regimes--whether aerobic, resistance, or endurance--ameliorate regional brain and functional deficits not only in affected individuals but also in animal models of the disorder. Cognitive deficits, often linked to regional deficits, were alleviated by exercise, as were quality-of-life, independent of disorder staging and risk level. Apoptotic processes intricate to the etiopathogenesis of schizophrenia were likewise attenuated by physical exercise. There is also evidence of manifest benefits endowed by physical exercise in preserving telomere length and integrity. Not least, exercise improves overall health and quality-of-life. The notion of scaffolding as the outcome of physical exercise implies the "buttressing" of regional network circuits, neurocognitive domains, anti-inflammatory defenses, maintenance of telomeric integrity, and neuro-reparative and regenerative processes.

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Shortened telomere in unremitted schizophrenia

Cited by 36 publications

References 43 publications

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Leukocyte telomere length: Effects of schizophrenia, age, and gender

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

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