Shortcut method for evaluation and design of a hybrid process for enantioseparations

Kaspereit, Malte; Gedicke, K.; Zahn, V.; Mahoney, Alan W.; Seidel‐Morgenstern, A.

doi:10.1016/j.chroma.2005.02.043

Cited by 53 publications

(47 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Afterwards, also consequences will be discussed for possible process combinations with a crystallizer at the raffinate outlet of the SMB unit (raffinate configuration). It should be noted that the process may also be performed using crystallizers at both outlets of the SMB (see, e.g., [1,3,7,8,11]. This work focuses on processes with a single crystallizer.…”

Section: Plant Configuration and Modelmentioning

confidence: 99%

“…Determination of the optimal coupling purity between the SMB unit and the crystallizer is of major importance to fully exploit the potential of the coupled process. For this purpose, Kaspereit et al [7] introduced a shortcut method. It is based on the purity/performance characteristics of the SMB unit combined with the assumption of established SLE and simple mass balances for the crystallization unit.…”

Section: Introductionmentioning

confidence: 99%

“…Application of the hybrid separation process SMB-crystallization has been discussed for different SLEs. Investigated systems are, e.g., praziquantel [5], mandelic acid [1,3,7], Tröger's base [8], threonine [3], methionine [9], bicalutamide [10], as well as the epimers of a diastereomeric compound [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

Swernath¹,

Kaspereit²,

Kienle³

2013

Chem Eng & Technol

View full text Add to dashboard Cite

The combination of continuous chromatographic processes and subsequent crystallization with a recycle of the mother liquor can improve significantly the efficiency of separation processes for the production of enantiomers if compared to the stand-alone chromatographic process. For the first time, dynamic operability and plantwide control of such a process combination is investigated. In the first step, the effect of disturbances on the open loop dynamics is evaluated. In a second step, a simple plantwide control strategy is proposed in order to ensure a robust process operation. It is demonstrated that the direct control of the simulated moving bed (SMB) unit is not required to stabilize the process combination while maintaining the desired product specifications. Instead, this can be achieved easily by controlling the amount of solvent removed or added to the system.

show abstract

Section: Plant Configuration and Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

Swernath¹,

Kaspereit²,

Kienle³

2013

Chem Eng & Technol

View full text Add to dashboard Cite

show abstract

“…Mit dem Ziel, das Potenzial solcher Hybridverfahren aus Chromatographie und Kristallisation systematischer und effizienter zu analysieren und zu bewerten, wurden "Short-CutMethoden" entwickelt. [275,304,305] Ein Vergleich konkurrierender Konzepte ist für das Beispiel Bicalutamid in Abbildung 35 gegeben. Die Ergebnisse zeigen, dass im Vergleich zum allein betriebenen SMB-Prozess mit dem gekoppelten Prozess bei einer "SMB-Übergabereinheit" von 92 % eine mehr als doppelt so hohe Produktivität der Gewinnung von R-Bicalutamid mçglich ist.…”

Section: Beispiele Präparativer Chromatographischer Enantiomerentrennunclassified

“…Dabei wurde hinsichtlich des Kristallisationsschrittes von der Annahme eingestellter Gleichgewichte ausgegangen. [304] Der Referenzfall war auch hier eine ausschließliche Anwendung des SMBVerfahren (100 % Reinheit). Für dieses spezielle Beispiel wurde eine optimale Übergabereinheit zwischen Chromatographie und Kristallisation von 93 % ermittelt, was zu einer Leistungssteigerung von etwa 45 % im Vergleich zur SMBChromatographie allein führte.…”

Section: Beispiele Präparativer Chromatographischer Enantiomerentrennunclassified

Verfahren zur Enantiomerentrennung

Lorenz

Seidel‐Morgenstern

2014

Angewandte Chemie

Self Cite

View full text Add to dashboard Cite

Die Verfügbarkeit reiner Enantiomere ist von steigender Bedeutung für die pharmazeutische Industrie sowie auch für die Agrochemie und Biotechnologie. Generell gibt es zwei konkurrierende Ansätze zur Gewinnung von reinen Enantiomeren. Der “chirale” Ansatz basiert auf der Entwicklung einer asymmetrischen Synthese, die selektiv eines der Enantiomere liefert. Der “racemische” Ansatz basiert auf der Trennung eines Gemischs der beiden Enantiomere, wobei hier in den letzten Jahren bemerkenswerte Fortschritte erzielt werden konnten. Dieser Aufsatz fokussiert insbesondere auf enantioselektive Kristallisationsprozesse und präparative Chromatographie, einschließlich hybrider Trennprozesse und der zusätzlichen Integration von Racemisierungsschritten. Zur Illustration dienen mehrere in unserem Arbeitskreis untersuchte Trennungen.

show abstract

Adsorption in Simulated Moving Beds

Santana

Silva

Azevedo

et al. 2009

Encyclopedia of Industrial Biotechnology

View full text Add to dashboard Cite

Chromatographic separation is based on the differential affinity of the components to a surface of solid adsorbent. While the batch or elution chromatography has found the largest number of applications up to now, Simulated Moving Bed (SMB) chromatography as a continuous process is gaining more attention due to its advantages in terms of productivity and eluent consumption. SMB is a multicolumn, continuous adsorption separation process that increases throughput, purity and yield relative to batch chromatography. Designing SMB processes involves, among other tasks, the selection of the number of columns per zone and the proper selection of the flowrates (feed, desorbent, raffinate, extract and recycle) and of the switching times in each cycle of operation. Nowadays, SMB technology has been applied to separation and purification of proteins, enantiomers and sugars. Several advances to improve SMB technology efficiency includes new configurations of equipment designs to provide more degrees of freedom than the classical process and also the implementation of the use of solvent gradient, temperature gradient and of supercritical fluids as eluents. The rise of biotechnological products within the marketplace for pharmaceuticals is but one example of how recent developments in this area are making a major impact.

show abstract

Shortcut method for evaluation and design of a hybrid process for enantioseparations

Cited by 53 publications

References 27 publications

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

Verfahren zur Enantiomerentrennung

Adsorption in Simulated Moving Beds

Contact Info

Product

Resources

About