Short-Wavelength Automated Perimetry and Retinal Nerve Fiber Layer Evaluation in Suspected Cases of Glaucoma

Abstract

To determine if short-wavelength automated perimetry (SWAP) provides evidence that indicates early functional losses in ocular hypertensive subjects and to establish a direct comparison with early structural abnormalities in the retinal nerve fiber layer (RNFL). Methods: A total of 160 eyes belonging to 83 patients with ocular hypertension (intraocular pressure Ͼ21 mm Hg and normal results on standard automated perimetry evaluation), on which a SWAP and RNFL study were performed, were examined. One hundred twenty-eight agematched subjects without ocular hypertension were evaluated to establish the 95% and 99% confidence intervals at each of the 76 exploration points of the SWAP test. Results: The RNFL study results were normal in 83 cases (51.8%) and pathologic in 77 cases (48.1%). The SWAP results were pathologic in 57 cases (35.6%). Significant differences (PϽ.001) were observed when comparing the distribution of normal and pathologic SWAP results among the types of defects in the RNFL (focal wedge, diffuse atrophy, and mixed atrophy). Conclusions: Short-wavelength automated perimetry is a useful test for the early detection of visual field losses. It is more sensitive than standard automated perimetry and provides a high association with RNFL assessment, which has proved capable of detecting signs of glaucomatous damage several years before the onset of the typical visual field defects.

Study of Patients with Ocular Hypertension with Scanning Laser Polarimetry and Short-Wavelength Automatic Perimetry

“…This is of particular importance since no previous study looked at the topographic correlation of defects. Previous studies using monochrome photographs detected RNFL defects in 85–92% of eyes with SWAP defects [14, 38]. In the present study SWAP defects were not always accompanied by detectable SLP defects.…”

“…This indicates that detectable RNFL defects may actually precede not only defects in WWP but also defects in SWAP. Similarly Polo et al [14] reported RNFL defects detected with RNFL photography in 24.5% of eyes with normal SWAP.…”

Study of Patients with Ocular Hypertension with Scanning Laser Polarimetry and Short-Wavelength Automatic Perimetry

“…This is of particular importance since no previous study looked at the topographic correlation of defects. Previous studies using monochrome photographs detected RNFL defects in 85–92% of eyes with SWAP defects [14, 38]. In the present study SWAP defects were not always accompanied by detectable SLP defects.…”

“…This indicates that detectable RNFL defects may actually precede not only defects in WWP but also defects in SWAP. Similarly Polo et al [14] reported RNFL defects detected with RNFL photography in 24.5% of eyes with normal SWAP.…”

Glaucomatous Damage Patterns by Short-Wavelength Automated Perimetry (SWAP) in Glaucoma Suspects

“…The specificity of SWAP in normal subjects is 94.5%, and this test is more sensitive than conventional automated perimetry in detecting glaucomatous visual field losses (26,27). The results of this study suggest that a diffuse sensitivity loss component is an early sign of glaucomatous damage over which focal defects develop with the progression of visual field damage.…”

Capacidad diagnóstica del stratus OCT para detectar glaucomas pre-perimétricos

“…Polo et al (19) by means of monochrome photographies) and alterations of the SWAP visual field in ocular hypertensive patients. Nonetheless, photographic analysis is a good method for assessing RNFL, requiring a transparent optical medium in order to obtain good photographies and staff trained to interpret the images adequately.…”

Study of Patients with Ocular Hypertension with Scanning Laser Polarimetry and Short-Wavelength Automatic Perimetry

“…This is of particular importance since no previous study looked at the topographic correlation of defects. Previous studies using monochrome photographs detected RNFL defects in 85–92% of eyes with SWAP defects [14, 38]. In the present study SWAP defects were not always accompanied by detectable SLP defects.…”

“…This indicates that detectable RNFL defects may actually precede not only defects in WWP but also defects in SWAP. Similarly Polo et al [14] reported RNFL defects detected with RNFL photography in 24.5% of eyes with normal SWAP.…”

Glaucomatous Damage Patterns by Short-Wavelength Automated Perimetry (SWAP) in Glaucoma Suspects

“…The specificity of SWAP in normal subjects is 94.5%, and this test is more sensitive than conventional automated perimetry in detecting glaucomatous visual field losses (26,27). The results of this study suggest that a diffuse sensitivity loss component is an early sign of glaucomatous damage over which focal defects develop with the progression of visual field damage.…”

Capacidad diagnóstica del stratus OCT para detectar glaucomas pre-perimétricos

“…Polo et al (19) by means of monochrome photographies) and alterations of the SWAP visual field in ocular hypertensive patients. Nonetheless, photographic analysis is a good method for assessing RNFL, requiring a transparent optical medium in order to obtain good photographies and staff trained to interpret the images adequately.…”

Study of Patients with Ocular Hypertension with Scanning Laser Polarimetry and Short-Wavelength Automatic Perimetry

“…This is of particular importance since no previous study looked at the topographic correlation of defects. Previous studies using monochrome photographs detected RNFL defects in 85–92% of eyes with SWAP defects [14, 38]. In the present study SWAP defects were not always accompanied by detectable SLP defects.…”

“…This indicates that detectable RNFL defects may actually precede not only defects in WWP but also defects in SWAP. Similarly Polo et al [14] reported RNFL defects detected with RNFL photography in 24.5% of eyes with normal SWAP.…”

Glaucomatous Damage Patterns by Short-Wavelength Automated Perimetry (SWAP) in Glaucoma Suspects

“…The specificity of SWAP in normal subjects is 94.5%, and this test is more sensitive than conventional automated perimetry in detecting glaucomatous visual field losses (26,27). The results of this study suggest that a diffuse sensitivity loss component is an early sign of glaucomatous damage over which focal defects develop with the progression of visual field damage.…”

Capacidad diagnóstica del stratus OCT para detectar glaucomas pre-perimétricos

“…Polo et al (19) by means of monochrome photographies) and alterations of the SWAP visual field in ocular hypertensive patients. Nonetheless, photographic analysis is a good method for assessing RNFL, requiring a transparent optical medium in order to obtain good photographies and staff trained to interpret the images adequately.…”