Short-time recovery skeletal muscle from dexamethasone-induced atrophy and weakness in old female rats

Alev, Karin; Aru, Maire; Vain, Arved; Pehme, Ando; Kaasik, Priit; Seene, Teet

doi:10.1016/j.clinbiomech.2022.105808

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…The variations in the effectiveness of vitamin D3 supplementation in terms of its protective role in the hippocampus versus the rest of the body seem to arise from the multifaceted impacts of DEXA on metabolism. These impacts primarily focus on reducing fat mass, inducing muscle wasting, causing intramuscular fat deposition, and leading to mitochondrial dysfunction [ 48 , 49 ]. The mechanism(s) of DEXA’s action resemble stress responses and are associated with hormone dysregulation, insulin resistance, hepatic hexokinase inhibition, and inhibition of glucose oxidation.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Vitamin D3 Protects against Mitochondrial Dysfunction and Loss of BDNF-Mediated Akt Activity in the Hippocampus during Long-Term Dexamethasone Treatment in Rats

Korewo-Labelle,

Karnia,

Myślińska

et al. 2023

IJMS

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Dexamethasone (DEXA) is a commonly used steroid drug with immunosuppressive and analgesic properties. Unfortunately, long-term exposure to DEXA severely impairs brain function. This study aimed to investigate the effects of vitamin D3 supplementation during chronic DEXA treatment on neurogenesis, mitochondrial energy metabolism, protein levels involved in the BDNF-mediated Akt activity, and specific receptors in the hippocampus. We found reduced serum concentrations of 25-hydroxyvitamin D3 (25(OH)D3), downregulated proBDNF and pAkt, dysregulated glucocorticosteroid and mineralocorticoid receptors, impaired mitochondrial biogenesis, and dysfunctional mitochondria energy metabolism in the DEXA-treated group. In contrast, supplementation with vitamin D3 restored the 25(OH)D3 concentration to a value close to that of the control group. There was an elevation in neurotrophic factor protein level, along with augmented activity of pAkt and increased citrate synthase activity in the hippocampus after vitamin D3 administration in long-term DEXA-treated rats. Our findings demonstrate that vitamin D3 supplementation plays a protective role in the hippocampus and partially mitigates the deleterious effects of long-term DEXA administration. The association between serum 25(OH)D3 concentration and BDNF level in the hippocampus indicates the importance of applying vitamin D3 supplementation to prevent and treat pathological conditions.

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Section: Discussionmentioning

confidence: 99%

Supplementation with Vitamin D3 Protects against Mitochondrial Dysfunction and Loss of BDNF-Mediated Akt Activity in the Hippocampus during Long-Term Dexamethasone Treatment in Rats

Korewo-Labelle,

Karnia,

Myślińska

et al. 2023

IJMS

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An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia

Huang,

Guo

et al. 2023

Experimental Gerontology

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Short‐term aerobic exercise prevents development of glucocorticoid myopathic features in aged skeletal muscle in a sex‐dependent manner

Laskin,

Rentería,

Muller‐Delp

et al. 2024

The Journal of Physiology

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Older adults are vulnerable to glucocorticoid‐induced muscle atrophy and weakness, with sex potentially influencing their susceptibility to those effects. Aerobic exercise can reduce glucocorticoid‐induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can prevent glucocorticoid myopathy in aged muscle. The objectives of this study were to define the extent to which sex influences the development of glucocorticoid myopathy in aged muscle, and to determine the extent to which aerobic exercise training protects against myopathy development. Twenty‐four‐month‐old female (n = 30) and male (n = 33) mice were randomized to either sedentary or aerobic exercise groups. Within their respective groups, mice were randomized to either daily treatment with dexamethasone (DEX) or saline. Upon completing treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic exercise only in females. DEX increased sub‐tetanic force and rate of force development only in females, which was not influenced by aerobic exercise. Muscle fatigue was higher in both sexes following DEX, but aerobic exercise prevented fatigue induction only in females. The sex‐specific differences to muscle function in response to DEX treatment coincided with sex‐specific changes to the content of proteins related to calcium handling, mitochondrial quality control, reactive oxygen species production, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short‐term aerobic exercise to protect against those changes. imageKey points There are sexually dimorphic effects of glucocorticoids on aged skeletal muscle physiology. Glucocorticoid‐induced changes to aged muscle contractile properties coincide with sex‐specific differences in the content of calcium handling proteins. Aerobic exercise prevents glucocorticoid‐induced fatigue only in aged females and coincides with differences in the content of mitochondrial quality control proteins and glucocorticoid receptors.

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Short-time recovery skeletal muscle from dexamethasone-induced atrophy and weakness in old female rats

Cited by 3 publications

References 47 publications

Supplementation with Vitamin D3 Protects against Mitochondrial Dysfunction and Loss of BDNF-Mediated Akt Activity in the Hippocampus during Long-Term Dexamethasone Treatment in Rats

Supplementation with Vitamin D3 Protects against Mitochondrial Dysfunction and Loss of BDNF-Mediated Akt Activity in the Hippocampus during Long-Term Dexamethasone Treatment in Rats

An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia

Short‐term aerobic exercise prevents development of glucocorticoid myopathic features in aged skeletal muscle in a sex‐dependent manner

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