2008
DOI: 10.1097/jcp.0b013e31817d5912
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Abstract: Although there are few studies on the treatment of schizophrenia with testosterone, several indirect findings have suggested testosterone as a possible treatment modality for schizophrenia. To explore the therapeutic effect of testosterone augmentation of antipsychotic medication on symptoms in male patients with schizophrenia, the authors performed a placebo-controlled, double-blind trial on 30 schizophrenic men, using either 5 g of 1% testosterone gel (Testogel; Besins Iscovesco, Paris, France) or a placebo … Show more

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Cited by 52 publications
(11 citation statements)
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References 58 publications
(54 reference statements)
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“…However, CAG repeat length, as an indirect measure of AR function in the brain, was not associated with changes in serum testosterone or symptom severity, suggesting that raloxifene effects may not be dependent on AR function for increased testosterone and symptom reduction. The only trial of testosterone augmentation therapy in men with schizophrenia found that 5 g of 1% testosterone gel over a 4-week peri od improved negative symptoms and increased total testosterone levels by an estimated mean of approximately 13 nmol/L [14]. In our study, the mean increase in circulating testosterone levels following raloxifene treatment from baseline in male patients was 3.2 nmol/L and, therefore, may not have reached the magnitude necessary to ameliorate symptoms.…”
Section: Discussionmentioning
confidence: 76%
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“…However, CAG repeat length, as an indirect measure of AR function in the brain, was not associated with changes in serum testosterone or symptom severity, suggesting that raloxifene effects may not be dependent on AR function for increased testosterone and symptom reduction. The only trial of testosterone augmentation therapy in men with schizophrenia found that 5 g of 1% testosterone gel over a 4-week peri od improved negative symptoms and increased total testosterone levels by an estimated mean of approximately 13 nmol/L [14]. In our study, the mean increase in circulating testosterone levels following raloxifene treatment from baseline in male patients was 3.2 nmol/L and, therefore, may not have reached the magnitude necessary to ameliorate symptoms.…”
Section: Discussionmentioning
confidence: 76%
“…Research has found that a deficit in circulating testosterone may adversely affect symptoms [3, 6, 10, 11] and cognition [8] in men with schizophrenia, suggesting a beneficial effect of increased androgens, as demonstrated in a trial of testosterone augmentation therapy [14]. Hormone replacement therapy with testosterone has been shown to be beneficial in older hypogonadal men, improving sexual function and mild mood symptoms [97]; however, the potential long-term side effects, such as cardiovascular events and prostate cancer [22, 98], are risks of testosterone replacement therapy.…”
Section: Discussionmentioning
confidence: 99%
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“…However, while there are indications of promise for hormone replacement in treating these deficits (Cherrier et al, 2001, Okun et al, 2006, Ko et al, 2008{Okun, 2006 #261) there are also significant carodiovascular contraindications for hormone replacement in males(Vigen et al, 2013). These could be mitigated by identifying the non-steroidal, neural mediators of hormone influence over cognitive information processing in the male brain.…”
mentioning
confidence: 99%