2019
DOI: 10.1002/acn3.705
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Abstract: Objective We aimed to evaluate the safety and effectiveness of short‐term remote ischemic postconditioning ( RIPC ) in acute stroke monkey models. Methods Acute stroke monkeys were allocated to four groups based on the number of limbs exposed to RIPC . RIPC was initiated by 5‐min cuff inflation/deflation cycles of the target limb(s) for 5–10 bouts. Vital signs, skin integrity, brain … Show more

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Cited by 19 publications
(41 citation statements)
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“…The majority of publications ( n = 81 experiments) induced transient focal cerebral ischaemia ranging from 10 to 120 min of MCAo. In three studies, 2022 ischaemia was induced by embolic MCAo and three studies used permanent models of middle cerebral artery occlusion. 2325 RIC was mostly administered by occlusion of the femoral arteries or hind limbs (Supplementary Table I), however, in one study RIC was achieved through infrarenal aortic occlusion (categorised as bilateral limb occlusion) 26 and another study occluded the unilateral renal artery.…”
Section: Resultsmentioning
confidence: 99%
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“…The majority of publications ( n = 81 experiments) induced transient focal cerebral ischaemia ranging from 10 to 120 min of MCAo. In three studies, 2022 ischaemia was induced by embolic MCAo and three studies used permanent models of middle cerebral artery occlusion. 2325 RIC was mostly administered by occlusion of the femoral arteries or hind limbs (Supplementary Table I), however, in one study RIC was achieved through infrarenal aortic occlusion (categorised as bilateral limb occlusion) 26 and another study occluded the unilateral renal artery.…”
Section: Resultsmentioning
confidence: 99%
“…This raises concern of treatment failure when moving into human clinical trials due to inter-species differences. There was only one study assessing larger gyrencephalic species, a recent study assessing the effects of RIPerC on stroke-related cardiac dysfunction in rhesus monkeys (five control, nine RIC) 22 ; multi-limb RIPC improved motor neurological scores (in addition to reducing cardiac enzymes, von-Willebrand factor and C-reactive protein) without affecting cerebral infarct volume, suggesting improvements might be mediated through improving endothelial injury and anti-inflammatory mechanisms. This study is confounded by a small sample size and the use of Propofol during anaesthesia, which interferes with RIC efficacy and a factor that may have contributed to the neutral findings in prior cardiac bypass surgery RIC trials.…”
Section: Discussionmentioning
confidence: 99%
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“…Remote ischemic conditioning is another more practical approach where transient ischemia and reperfusion applied to a remote organ or tissue, protects other organs or tissues from further episodes of lethal ischemia/reperfusion injury. For example, ischemia on the limb protects the brain from subsequent ischemic injury [5][6][7]. Ischemic conditioning can be delivered before (preconditioning), during (perconditioning) or after (postconditioning) the ischemic insult [8].…”
Section: Introductionmentioning
confidence: 99%
“…The most important advantages of RIPC include its low cost, ease of performance and almost impeccable safety for patients. Thus, numerous clinical studies have been conducted to explore effects and potential mechanism of RIPC in different areas, such as organ transplantation, cardiac surgery, hepatic surgery and neurosurgery[ 9 , 18 , 34 - 36 ]. Studies have demonstrated that RIPC mainly occurs in two “windows,” one of which is the initial period following the preconditioning stimulus, which can last for 1-4 h[ 37 , 38 ], while the other happens at 24 h following preconditioning, which can last for 24-72 h[ 39 ].…”
Section: Discussionmentioning
confidence: 99%