Short-term effects of bicarbonate/lactate-buffered and conventional lactate-buffered dialysis solutions on peritoneal ultrafiltration: a comparative crossover study

Pajek, Jernej; Kveder, Radoslav; Bren, Andrej; A, Gucek; Bučar, Maja; Škoberne, Andrej; Waniewski, Jacek; Lindholm, Bengt

doi:10.1093/ndt/gfn673

Cited by 45 publications

(50 citation statements)

References 19 publications

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“…In patients who receive nocturnal APD with short dwell times as routine therapy: (298). Therefore, prolongation of the dwell time, such that at least partial normalization of the peritoneal "milieu" and, ideally, improved bacterial killing occurs, is a reasonable alteration to the dialysis prescription to aid in early peritonitis treatment.…”

Section: Guideline 20 -Modification Of Apdmentioning

confidence: 99%

Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update

et al. 2012

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Section: Guideline 20 -Modification Of Apdmentioning

confidence: 99%

Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update

et al. 2012

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“…Pajek et al (37) compared the shortterm effects of a low GDP peritoneal dialysis solution and a conventional PDS in the intraperitoneal and systemic inflammation. According to the authors, despite the significant reduction of intraperitoneal IL-6 concentration in patients using the bicarbonate and lactate solution, the serum levels of inflammatory markers did not differ between the two solutions.…”

Section: Discussionmentioning

confidence: 99%

Relationship between peritoneal permeability with inflammation and subclinical atherosclerosis in peritoneal dialysis patients

Yayar¹,

Eser²,

Bozkurt³

2017

J Turgut Ozal Med Cent

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Aim: High permeability in peritoneal dialysis (PD) is reported to be associated with increased mortality. Cardiovascular disease is the most important cause of morbidity and mortality in patients with end-stage renal disease. The inflammation is thought to take part in development of atherosclerosis. The aim of this study is to investigate the relation of peritoneal permeability type with carotid intima media thickness (CIMT) in PD patients. Material and Methods: Based on the standard peritoneal equilibration test, 56 PD patients (28 male) were divided in two transporter groups: low (low+low average) and high (high+high average) permeability. C-reactive protein (CRP) measured as a marker of inflammation and CIMT was evaluated by high-resolution B-mode ultrasonography. Results: Twenty one patients were low and 35 of them were high peritoneal transporters. Mean CRP level was significantly higher in the high permeability group (HPG) (1.62±1.7 vs 0.84±1 mg/dL; p=0.006). CIMT was higher in the HPG but this difference did not reach statistical significance (0.810±0.160 vs 0.740±0.160 mm; p=0.16). Conclusions: CRP, an indicator of inflammation, was found to be higher in the HPG. CIMT also was found to be higher in HPG although it was not statistically significant. One of the causes of increased mortality rate in this group of patients may be explained by inflammation and atherosclerosis.

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“…Bu tehlikeli özellik yüksek osmolaritenin, dializatın asiditesinin ve /veya yüksek laktat içeriğinin de bir sonucu olabilir (1). Yapılan bir çalışmada düşük GDP'nin intraperitoneal inflamasyonu azalttığı gösterilmiştir fakat diğer çalışmalar-la bu bulgu desteklenmemiştir (54,55). Uzun dönem klinik kullanımda ikodekstrin kullanımının glukozlu solüsyonda görülen periton savunma mekanizmasını kötüleştirmediği gö-rülmüştür.…”

Section: Metabolik Etkileriunclassified

Peri̇ton Di̇yali̇z Sıvıları (Peritoneal Dialysis Solutions)

Dinçel¹,

Bulut²,

Mır³

2014

ZKTB

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ÖZETPeriton diyalizi (PD) son dönem böbrek hastaları için önemli bir renal replasman tedavi yöntemi-dir. Hastalar evde uygulanan PD tedavisine kolayca uyum sağlarlar. Geleneksel standart periton diyaliz solüsyonları osmotic ajan olarak glukoz kullanırlar. Glukoz içeren diyaliz sıvıları yüksek konsantrasyonda glukoz içerirler. Laktat ve glukoz yıkım ürünleri-nin oluşmasına neden olurlar. Yüksek osmolalite ve düşük pH'a sahiptirler. Tüm bu sayılan özellikler peritona zarar verir (fibrosis, neoanjiogenez). Yeni PD solüsyonları alternatif tampon sistemleri ve ozmotik ajan kullanırlar (ikodekstrin ve aminoasitler). Yük-sek pH'ya sahip olup daha az glukoz yıkım ürünleri-nin oluşumuna neden olurlar. Yeni PD solüsyonları-nın kullanımı ile daha iyi metabolic kontrol ve vücut kompozisyonu sağlanabilir. Yeni solüsyonların kullanımı daha az fibrozise yol açar ve antiinflamatuvar özelliklerinden dolayı da periton zarı viabilitesini arttırırlar. Ama hasta sağ kalımını artırdıklarına dair kanıt yoktur. Bu derlemenin ile PD için kullanılan farklı tipte periton diyaliz sıvılarının tanımlaması ve gözden geçirilmesi amaçlanmıştır.Anahtar kelimeler: kronik böbrek yetmezliği, periton diyalizi, periton diyaliz solüsyonu ABSTRACT Peritoneal dialysis (PD) is an important kidney replacement therapy for end stage renal disease (ESRD) patients. Patients easily adapt at home based treatment of PD. Standard traditional solutions uses glucose as an osmotic agent. Glucose based dialysis solutions contains high concentrations of glucose. They cause production of glucose degradation products and lactate. They have high osmolality, and low pH. All these features damage to the peritoneum by fibrosis and neoangiogenesis. Newer PD solutions were produced with alternative buffers and osmotic agents (icodextrin or amino acids). They have a higher pH and causes production of fewer glucose degradation products. With the usage of newer PD solutions we can achieve better metabolic controls of patients and body compositions. Peritoneal membrane viability increases by their less fibrotic and less inflammatory features of new solutions. But their effect on patient survival is not clearly identified yet. The aim of this review is to describe and to overview the different types of peritoneal dialysissolutions used during PD.

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Short-term effects of bicarbonate/lactate-buffered and conventional lactate-buffered dialysis solutions on peritoneal ultrafiltration: a comparative crossover study

Cited by 45 publications

References 19 publications

Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update

Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update

Relationship between peritoneal permeability with inflammation and subclinical atherosclerosis in peritoneal dialysis patients

Peri̇ton Di̇yali̇z Sıvıları (Peritoneal Dialysis Solutions)

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