2013
DOI: 10.1017/s1461145713000916
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Increases in alpha calcium/calmodulin-dependent protein kinase type II (αCaMKII) activity in the nucleus accumbens shell has been proposed as a core component in the motivation to self-administer cocaine and in priming-induced drug-seeking. Since cocaine withdrawal promotes drug-seeking, we hypothesized that abstinence from cocaine self-administration should enhance αCaMKII as well. We found that short-term abstinence from contingent, but not non-contingent, cocaine i.v. self-administration (2 h/d for 14 d; 0.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
11
1
1

Year Published

2014
2014
2023
2023

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 17 publications
(13 citation statements)
references
References 25 publications
0
11
1
1
Order By: Relevance
“…For instance, priming-induced reinstatement of morphine-seeking is associated with increased pCaMKII-T286 in the AcbSh, but not AcbC, as compared to extinction controls (Liu et al, 2012). Short-term abstinence from cocaine self-administration is associated with increased CaMKII-T286 expression in the nucleus accumbens and medial prefrontal cortex, but not dorsolateral striatum (Caffino et al, 2014). Reinstatement of cocaine-seeking behavior is also associated with increased pCaMKII-T286 expression specifically in the AcbSh but not AcbC (Anderson et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…For instance, priming-induced reinstatement of morphine-seeking is associated with increased pCaMKII-T286 in the AcbSh, but not AcbC, as compared to extinction controls (Liu et al, 2012). Short-term abstinence from cocaine self-administration is associated with increased CaMKII-T286 expression in the nucleus accumbens and medial prefrontal cortex, but not dorsolateral striatum (Caffino et al, 2014). Reinstatement of cocaine-seeking behavior is also associated with increased pCaMKII-T286 expression specifically in the AcbSh but not AcbC (Anderson et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Enhanced aCaMKII gene expression and phosphorylation in the ventral striatum (vS) seem to be pivotal for the motivation to self-administer cocaine [5] as well as the reinstatement of cocaine seeking [6]. We have recently contributed to this topic by showing that short-term abstinence from cocaine selfadministration enhances aCaMKII autophosphorylation in the vS and medial prefrontal cortex (PFC) [7], suggesting that this kinase is regulated not only by cocaine-taking but also by its cessation, implying a role of this kinase in cocaine withdrawal syndrome. In addition, by employing a yoked control paradigm, we demonstrated that cocaine-induced elevation of aCaMKII autophosphorylation occurs only in the animals that self-administered cocaine, further strengthening its role in the motivation to self-administer the drug [7].…”
Section: Introductionmentioning
confidence: 99%
“…We have recently contributed to this topic by showing that short-term abstinence from cocaine selfadministration enhances aCaMKII autophosphorylation in the vS and medial prefrontal cortex (PFC) [7], suggesting that this kinase is regulated not only by cocaine-taking but also by its cessation, implying a role of this kinase in cocaine withdrawal syndrome. In addition, by employing a yoked control paradigm, we demonstrated that cocaine-induced elevation of aCaMKII autophosphorylation occurs only in the animals that self-administered cocaine, further strengthening its role in the motivation to self-administer the drug [7]. Notably, the potential role of aCaMKII in the action of cocaine has been recently expanded including a novel mechanism of aCaMKII regulation such as the phosphorylation at serine 331 [8].…”
Section: Introductionmentioning
confidence: 99%
“…Sabe-se que uma das funções do lobo frontal seria a de impedir pensamentos negativos, distrações e sentimentos. É possível inferir, por exemplo, que usuários de jogos eletrônicos ou de drogas, que apresentem disfunção no córtex frontal medial, possam ter maior dificuldade em resistir às emoções e aos pensamentos que o induzam a repetir a experiência de dependência [46][47][48] .…”
Section: Discussionunclassified