Short and tandem syntheses of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione via diethyl acetonedicarboxylate

Updating Dimedone─The Humble Hero of the Organic Laboratory

“…For example, leptospermone is a naturally occurring herbicide produced by Callistemon citrinus, and piroxicam is an anti-inflammatory drug used for the treatment of arthritis . By learning how to synthesize dimedone, students will gain the skills to synthesize more complex analogues, such as spiro-1,3-cyclohexadiones, which are key intermediates in the synthesis of pharmaceutical products such as CETP inhibitors (Figure ). Dimedone itself has been used as a precursor for the synthesis of more complex molecules. , …”

Tunable synthesis of α,β-multifunctionalized azaheterocycles via the cascade reaction of saturated cyclic amines with diverse nucleophiles promoted by oxoammonium salt

“…Third, using ethyl 3-oxo-4-(4-oxoquinazolin-3(4 H )-yl)butanoate ( 14 ) as a nucleophile to react with 1a , the α-alkyl-β-oxo cyclic amine 15 was easily obtained by our developed strategy. This resulting product can undergo mature reduction, de-esterification and N -deprotection 13–15 to furnish compound I , which exhibits antimalarial activity with high selectivity against P. falciparum (Scheme 6, 3). 1 a…”