Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids

Judée, Florian; Fongia, Céline; Ducommun, Bernard; Yousfi, Mohammed; Lobjois, Valérie; Merbahi, Nofel

doi:10.1038/srep21421

Cited by 132 publications

(107 citation statements)

References 42 publications

(54 reference statements)

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“…Thus, plasma provides an interesting opportunity to interfere with redox‐based processes in cancer cells by effectively inhibiting cell growth and inducing apoptosis, also in leukemic cells . Importantly, plasma‐treated solutions were shown to exhibit anticancer effects as well …”

Section: Introductionmentioning

confidence: 99%

Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

Schmidt

Rödder

Hasse

et al. 2016

Plasma Processes & Polymers

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Targeting cancer cells with cold physical plasma emerged as a promising application in plasma medicine. To understand its mode of action with regard to cellular redox‐regulation, two leukemia cell lines (Jurkat and THP‐1 cells) were plasma‐treated and their gene expression was compared. Transcriptomics revealed strikingly similar expression levels of activator protein 1 family members, and of a particular set of genes associated with apoptosis, DNA repair, and antioxidant defense. Interestingly, important constitutively expressed antioxidant transcripts were differently expressed in both cell types which suggest them to be crucial for the Jurkat's high and the THP‐1 cells’ low sensitivity to plasma. Utilizing these targets as biological read outs may help rendering plasmas more effective against different types of cancers.

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Section: Introductionmentioning

confidence: 99%

Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

Schmidt

Rödder

Hasse

et al. 2016

Plasma Processes & Polymers

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“…ROS production caused by non-thermal plasma appeared as a promising approach for the treatment of various diseases including cancer. Non-thermal plasma generated high amount of ROS, leading to the formation of DNA damage [41]. It resulted in cell cycle arrest and consequently in apoptosis induction [42].…”

Section: Discussionmentioning

confidence: 99%

Safety aspects of atmospheric pressure helium plasma jet operation on skin: In vivo study on mouse skin

et al. 2017

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Biomedical applications of plasma require its efficacy for specific purposes and equally importantly its safety. Herein the safety aspects of cold plasma created with simple atmospheric pressure plasma jet produced with helium gas and electrode discharge are evaluated in skin damage on mouse, at different duration of exposure and gas flow rates. The extent of skin damage and treatments are systematically evaluated using stereomicroscope, labelling with fluorescent dyes, histology, infrared imaging and optical emission spectroscopy. The analyses reveal early and late skin damages as a consequence of plasma treatment, and are attributed to direct and indirect effects of plasma. The results indicate that direct skin damage progresses with longer treatment time and increasing gas flow rates which reflect changes in plasma properties. With increasing flow rates, the temperature on treated skin grows and the RONS formation rises. The direct effects were plasma treatment dependent, whereas the disclosed late—secondary effects were more independent on discharge parameters and related to diffusion of RONS species. Thermal effects and skin heating are related to plasma-coupling properties and are separated from the effects of other RONS. It is demonstrated that cumulative topical treatment with helium plasma jet could lead to skin damage. How these damages can be mitigated is discussed in order to provide guidance, when using atmospheric pressure plasma jets for skin treatments.

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“…Hence the interaction of atmospheric pressure plasmas with liquids was recently subject to a number of studies …”

Section: Introductionmentioning

confidence: 99%

Effect of cold atmospheric plasmas on bacteria in liquid: The role of gas composition

Kaupe

Tschang

Birk

et al. 2019

Plasma Processes & Polymers

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In order to study the impact of different gas compositions on the bactericidal efficiency of cold atmospheric plasma jets, a device with a controlled atmosphere is built. Various mixtures of argon and helium with air are studied regarding their sterilizing effect on Escherichia coli in solution. Bacteria reduction rates react fundamentally different on addition of air in both gases. In case of helium, a distinct maximum for small admixtures is observed. Several diagnostic techniques were applied to the plasma. Stronger formation of peroxynitrous acid due to higher concentrations of hydrogen peroxide and nitrite is found to be responsible for the observed trends and differences. The presented findings are important for the development of efficient treatment devices.

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Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids

Cited by 132 publications

References 42 publications

Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

Safety aspects of atmospheric pressure helium plasma jet operation on skin: In vivo study on mouse skin

Effect of cold atmospheric plasmas on bacteria in liquid: The role of gas composition

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