1999
DOI: 10.1037/0735-7044.113.3.539
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Abstract: Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explored whether shock-induced hyperalgesia depends on neurons within rostral or caudal portions of the dorsolateral periaqueductal gray (dlPAG). Experiment 1 examined the impact of dlPAG lesions on the … Show more

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Cited by 30 publications
(35 citation statements)
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“…In fact, the present results could have been obtained from eyeblinks emanating from startle or nociceptive circuitry, because a similar pattern of modulation has been observed for startle eyeblinks evoked by non-noxious acoustic stimuli Cuthbert et al, 1996;Lang et al, 1997) and reactions that are nociceptive in origin (pain, NFR) (Rhudy et al, 2005(Rhudy et al, , 2006(Rhudy et al, , 2007a. Furthermore, startle and nociception may be modulated by a common circuit (e.g., amygdala & PAG) (Crown et al, 2000;Davis, 1997;Fanselow, 1994;Fendt et al, 1994;Lang and Davis, 2006;Manning and Mayer, 1995;McLemore et al, 1999). Although additional research is needed to address this issue, our data suggest eyeblinks elicited by noxious electric stimulation of the sural nerve do not habituate as quickly as eyeblinks elicited by acoustic startle probes or electrical probes delivered to the arm.…”
Section: Discussionsupporting
confidence: 51%
“…In fact, the present results could have been obtained from eyeblinks emanating from startle or nociceptive circuitry, because a similar pattern of modulation has been observed for startle eyeblinks evoked by non-noxious acoustic stimuli Cuthbert et al, 1996;Lang et al, 1997) and reactions that are nociceptive in origin (pain, NFR) (Rhudy et al, 2005(Rhudy et al, , 2006(Rhudy et al, , 2007a. Furthermore, startle and nociception may be modulated by a common circuit (e.g., amygdala & PAG) (Crown et al, 2000;Davis, 1997;Fanselow, 1994;Fendt et al, 1994;Lang and Davis, 2006;Manning and Mayer, 1995;McLemore et al, 1999). Although additional research is needed to address this issue, our data suggest eyeblinks elicited by noxious electric stimulation of the sural nerve do not habituate as quickly as eyeblinks elicited by acoustic startle probes or electrical probes delivered to the arm.…”
Section: Discussionsupporting
confidence: 51%
“…The rats were then injected with an assigned dose of morphine sulfate (Sigma-Aldrich, St. Louis) and, 30 minutes later, were placed in the restraining tubes and nociceptive reactivity was assessed. Nociceptive reactivity was assessed with gradually incremented shock and radiant heat, as described in prior studies [e.g., 9,16,17]. Briefly, subjects were placed in the restraining tubes, and the apparatus used to assess reactivity was attached to the tail.…”
Section: Assessment Of Motor/sensory Recoverymentioning
confidence: 99%
“…Our recent work has focused on a third mode of defense that is elicited under low to moderate levels of aversive stimulation (Meagher et al in review). Like the circa-strike mode, it depends on the dlPAG (McLemore et al 1999) and may occur as an unconditioned response to aversive stimulation (Illich et al 1995). However, it has the opposite effect on pain and learning, sensitizing both, an outcome indicative of hyperalgesia.…”
Section: Discussionmentioning
confidence: 98%