Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats

Jambi, Ebtihaj J.; Alshubaily, Fawzia A.

doi:10.1016/j.sjbs.2022.103393

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…[ 40 ] Recently, it has been shown that chemotherapeutics enhance blood ALT, AST, and ALP enzyme activities. [ 41,42 ] In addition, OXL can imbalance the concentration of urea. Ahmed et al [ 43 ] showed that the use of OXL to treat colon adenocarcinoma causes liver, kidney, and bone marrow toxicity.…”

Section: Discussionmentioning

confidence: 99%

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Ileriturk,

Kandemir

et al. 2023

J Biochem & Molecular Tox

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Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of biological and pharmacological activities, including antioxidant and anti‐inflammatory potentials. This research aimed to investigate NRG activity in OXL‐induced hepatorenal toxicity. Accordingly, OXL (4 mg/kg b.w.) in 5% glucose was injected intraperitoneally on the first, second, fifth, and sixth days, and NRG (50 and 100 mg/kg b.w.) was given orally 30 min before to treatment. Biochemical, genetic, and histological methods were utilized to investigate the function tests, oxidant/antioxidant status, inflammation, apoptosis, and endoplasmic reticulum (ER) stress pathways in kidney and liver tissues. Administration of NRG demonstrated an antioxidant effect by increasing the activities of OXL‐induced reduced antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the elevated lipid peroxidation parameter malondialdehyde levels. Nuclear factor‐κB, tumor necrosis factor‐α, interleukin‐1β, and inducible nitric oxide synthase levels increased in OXL administered groups but reduced in NRG‐treated groups. In the OXL‐administered groups, NRG reduced the apoptosis‐inducing factors Caspase‐3 and B‐cell lymphoma 2 (Bcl‐2)‐associated X protein levels, while elevating the antiapoptotic factor Bcl‐2 levels. OXL triggered prolonged ER stress by increasing the levels of ER stress parameters activating transcription factor 6, protein kinase R‐like ER kinase, inositol‐requiring enzyme 1α, and glucose‐regulated protein 78. Therefore, with the NRG administration, this activity was reduced and the ER stress level decreased. Taken together, it was found that OXL induced toxicity by increasing the levels of urea and creatinine, alanine transaminase, aspartate aminotransferase, and alkaline phosphatase activities, inflammation, apoptosis, ER stress, and oxidants in the liver and kidney tissue, and NRG had a protective effect by reversing the deterioration in these pathways.

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Section: Discussionmentioning

confidence: 99%

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Ileriturk,

Kandemir

et al. 2023

J Biochem & Molecular Tox

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“…Similar results were also obtained by previous workers [ 37 ]. Likewise, shilajit was reported to heal fractured bones in children with a daily oral dose of 0.1 g/kg, which accelerated phosphorus uptake and callus formation in the fractured bones [ 5 ]. Various dosages of shilajit healed fractured bones differently, but the one resulting in the maximum healing in experimental rats was to be started at the earliest onset of fracture at a daily oral dose ranging between 260 and 300 mg/kg for less than seven days [2;37].…”

Section: Discussionmentioning

confidence: 99%

“…High dose shilajit treatment demonstrated an osteoprotective effect in animal models of osteoporosis, where bone integrity was primarily involved due to increased calcium, phosphorus, and CT levels. In other words, antioxidant parameters were improved due to the osteogenic effects of SWE [ 5 ]. Treatments of osteoporosis with SWE and SWE/NCT open new doors and novel perspectives to achieve positive results and benefit osteoporotic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Shilajit is characterized as a multi-component natural mineral medicine, traditionally used for the treatments of libido, injury, aging, immunity, obesity, blood sugar, and arthritis [ 4 , 5 ]. Shilajit is a natural blackish-brown herbal compound, which contains fulvic and fulvic acids and is considered safe to be taken orally as part of a person’s everyday diet [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Antioxidant and Anti-Osteoporotic Activities of Shilajit Loaded into Chitosan Nanoparticles and Their Effects on Osteoporosis in Rats

Alshubaily

Jambi

2022

Polymers

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Various therapies for osteoporosis successfully reduce bone loss and fractures, but they mostly do not contribute to new bone structures and adversely affect patients. Shilajit is a natural mineral substance comprised of multi-components, with proved efficacy to improve immunity, antioxidant activity, and disease resistance. In the present study, various effects of shilajit water extract (SWE) on bone development and its management were determined in experimental glucocorticoid-induced osteoporotic rats. The fabrication of nanochitosan (NCT) and NCT conjugation with SWE were conducted and evaluated as enhanced formulations for treating osteoporosis. NCT and SWE/NCT had mean particle diameters of 196.4 and 248.4 nm, respectively, with high positivity charging and stability. The biochemical and anti-osteoporotic effects of SWE and SWE/NCT conjugates were investigated on different groups of compromised rats. Five groups each including six adult albino female rats were formed and treated for a duration of eight weeks with SWE and SWE/NCT conjugate. Significantly improved serum calcium, phosphorus, osteocalcin, and calcitonin levels but decreased hydrogen peroxide, IL-6, and antioxidant biomarkers were recorded in all SWE- and SWE/NCT-treated groups; the SWE/NCT treatment was most effectual treatment. These results suggest that SWE and SWE/NCT may cause anti-osteoporotic activity by reducing oxidative stress, IL-6, and H2O2 while restoring antioxidant levels. The conjugation of SWE onto NCT is highly recommended for augmenting their activities.

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Hazardous or Advantageous: Uncovering the Roles of Heavy Metals and Humic Substances in Shilajit (Phyto-mineral) with Emphasis on Heavy Metals Toxicity and Their Detoxification Mechanisms

Hussain,

Saeed

2024

Biol Trace Elem Res

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Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats

Cited by 4 publications

References 44 publications

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Correlation between Antioxidant and Anti-Osteoporotic Activities of Shilajit Loaded into Chitosan Nanoparticles and Their Effects on Osteoporosis in Rats

Hazardous or Advantageous: Uncovering the Roles of Heavy Metals and Humic Substances in Shilajit (Phyto-mineral) with Emphasis on Heavy Metals Toxicity and Their Detoxification Mechanisms

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