Landslides are often deadly natural events. Steep slopes and certain loose soil types are predestined areas for them. Moreover, in the context of climate change, extreme weather events such as heavy rainfall, which often trigger landslides, are becoming even more likely. All this is well known. It therefore stands to reason that this knowledge will lead to the avoidance of these risks. On the other hand, however, there are highly dynamic urbanization processes which often overtake formal urban planning processes by rising population figures and areal expansion. In the course of these processes, economically-deprived population groups often have no other option than to informally build on high-risk areas. Against these backgrounds, we systematically examine in this study how these risks develop over a 24 years’ time period with respect to the city-wide exposure and in particular with respect to different social groups. For this purpose, we use heterogeneous input data from remote sensing, hazard maps and census data. Our case study is the city of Medellín in Colombia. We develop and apply a set of methods integrating the heterogenous data sets to map, quantify and monitor exposure and social vulnerability at a finer spatial resolution than administrative units. Our results document first of all the highly dynamic growth in total population and urban areas. However, our results reveal that the city's expansion is socially unevenly distributed. People of higher vulnerability proxied by informal settlements are found to settle in significantly more areas exposed to landslides. This study proposes a methodological set-up that allows to monitor exposure and social vulnerability over long time spans, allows to bring inequality into the spotlight and provide decision makers with better information to develop socially responsible policies.