2007
DOI: 10.1161/circulationaha.106.684852
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Abstract: Background-The astonishing thickness of the endothelial glycocalyx, which rivals that of endothelial cells in the microvasculature, was disclosed in the last 15 years. As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability. Methods and Results-Two components of the glycocalyx, syndecan-1 and heparan sulfate, were measured in arterial blood of 18 patients undergoing surgery of the ascending aorta with cardiopulmonary bypass (nϭ12 with and nϭ6 without… Show more

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Cited by 543 publications
(487 citation statements)
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“…These data were approved by a clinical investigation, which showed increased plasma levels of syndecan-1 and heparan sulphate in patients with global or regional ischemia who underwent major vascular surgery [18].…”
Section: The Endothelial Surface Layer and The Pathogenesis Of Extramentioning
confidence: 99%
“…These data were approved by a clinical investigation, which showed increased plasma levels of syndecan-1 and heparan sulphate in patients with global or regional ischemia who underwent major vascular surgery [18].…”
Section: The Endothelial Surface Layer and The Pathogenesis Of Extramentioning
confidence: 99%
“…Patients with type 1 diabetes and microalbuminuria showed higher levels of syndecan-1 in serum than patients without microalbuminuria and controls (Svennevig et al 2006). Shedding of syndecan-1 may be regarded as a protective mechanism during heart surgery (Rehm et al 2007;Svennevig et al 2008), infections (Park et al 2000), and possibly also in diabetes. Only a limited number of studies have addressed syndecan shedding in diabetes (Wang J-B et al 2009).…”
Section: Hs Changes In Dnmentioning
confidence: 99%
“…33,34 Elevated shedding products, reflecting ESL breakdown, have been found in patients with severe sepsis, CKD, or ESRD, patients on dialysis, patients after major vascular surgery, and patients during acute or chronic hyperglycemia. 31,33,[35][36][37][38][39][40] Most of these conditions associated with a perturbed ESL are also characterized by an expanded ECV, higher BP, or both, suggesting that variability in sodium homeostasis and salt sensitivity may be related to the quality of the ESL, in which endothelial GAGs act as an intravascular buffer compartment for sodium.Considering the large ESL volume, it seems likely that, next to the skin interstitium, nonosmotic sodium storage by endothelial GAGs is a clinically relevant sodium buffer. In patients on hemodialysis, for example, increased plasma syndecan-1 levels, reflecting ESL breakdown, have been associated with an increased need for ultrafiltration, advocating that loss of ESL sodium buffer capacity is clinically relevant in patients prone to volume overload.…”
mentioning
confidence: 99%