Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

Jalalvandi, Esmat; Shavandi, Amin

doi:10.1016/j.jmbbm.2018.10.009

Cited by 36 publications

(18 citation statements)

References 53 publications

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“…[ 86–88 ] So as a safe alternative, mostly harmless visible light has come into sight. [ 89–91 ] Jalalvandi et al. designed dual crosslinking hydrogels with secondary photo crosslinking based on a methacrylated gelatin.…”

Section: Strategies For Preparing Injectable Dual Crosslinking Hydrogelsmentioning

confidence: 99%

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Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

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Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

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Section: Strategies For Preparing Injectable Dual Crosslinking Hydrogelsmentioning

confidence: 99%

“…designed dual crosslinking hydrogels with secondary photo crosslinking based on a methacrylated gelatin. [ 89 ] After the precursors were injected, the second crosslinking continued in vivo by exposure to visible green light to polymerize methacrylate groups. Similarly, Wang et al.…”

Section: Strategies For Preparing Injectable Dual Crosslinking Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

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“…The samples were cut into two equal halves using a cutter, kept in contact with each other and pressed together for some time. The self-healing behavior was observed after certain time (Ginting, Pasaribu, Masmur, Kaban & Hestina, 2020;Yang, Lu, Zhang & Zhou, 2015;Chen et al, 2017;Jalalvandi & Shavandi, 2018;Naghizadeh, Karkhaneh & Khojasteh, 2018).…”

Section: Self-healing Behaviormentioning

confidence: 99%

Borax assisted synthesis of dialdehyde Carboxymethyl cellulose-Dextrin/Gelatin based biocompatible self-healing hydrogel

Sharma¹,

Bhalla²,

Kaith³

et al. 2021

Preprint

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The hydrogels with self-healing properties have high potential applications in the biomedical field. Generally, the imine bonds are used as the dynamic covalent bonding in the self-healing hydrogels and hydrogen bonding is used for providing additional strength to self-healing hydrogels. In the presented work, Gelatin, dialdehyde dextrin, and dialdehyde Carboxymethyl cellulose (CMC) based hydrogels were prepared which are biocompatible and biodegradable and hence, can be used in biomedical field. Borax and glutaraldehyde were used as binding agent and cross-linker, respectively. The dynamic imide bond formed between gelatin-dialdehyde dextrin, gelatin-dialdehyde CMC, and gelatin-glutaraldehyde were responsible for self-healing ability of the prepared hydrogel. The rheological studies were also carried out which showed that as a consequence of lower viscosity the hydrogels can show injectable properties. The sample was also found to be blood compatible, which further highlights its biomedical importance.

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“…Shear-thinning hydrogels are formed by ex vivo self-assembly through physical interactions such as hydrogen bonding, hydrophobic interactions, and guest–host interactions [ 311 ]. These hydrogels become injectable under high mechanical shear and are capable of flowing through a needle, reforming their bonds and forming a cohesive depot at the injection site [ 312 ].…”

Section: Polypeptide Deliverymentioning

confidence: 99%

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

et al. 2020

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Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

Cited by 36 publications

References 53 publications

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Borax assisted synthesis of dialdehyde Carboxymethyl cellulose-Dextrin/Gelatin based biocompatible self-healing hydrogel

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

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