Shear Stress‐Responsive Polymersome Nanoreactors Inspired by the Marine Bioluminescence of Dinoflagellates

Rifaie‐Graham, Omar; Galensowske, Nikolas F. B.; Dean, Charlie; Pollard, Jonas; Balog, Sandor; Gouveia, Micael G.; Chami, Mohamed; Vian, Antoine; Amstad, Esther; Lattuada, Marco; Bruns, Nico

doi:10.1002/anie.202010099

Cited by 32 publications

(33 citation statements)

References 58 publications

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“…Incorporation of magnetic particles Iron nanoparticles [29,30] Shear stress Flexible particles, generally hydrogels ADEN/THYM polymersomes Adenine/thymine functionalized block co polymers [31] 2.1. Internal Stimuli…”

Section: Magnetismmentioning

confidence: 99%

“…Some micelles and polymersomes have been studied due to their ability to deform their shape and release the drug under specific shear conditions. Rifaie-Graham et al synthesized polymersomes that change shape with shear stress, thereby releasing the cargo in high shear stress conditions [31]. Shen et al prepared micelles that are responsive to ROS production and shear stress to treat atherosclerosis, which is a type of cardiovascular disease [102].…”

Section: Othersmentioning

confidence: 99%

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Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

2022

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Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it.

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Section: Magnetismmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

2022

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“…18 Among them, DDS that responds to mechanical force stimuli, which has a wide range of sources in organisms and is of great significance in life activities, has recently attracted many interests. 19 For example, the compressive force of articular cartilage during movement, 20 the tensile force of muscles during exercise, 21 and the high shear force in case of vascular disease 22 can be utilized to trigger the release of drugs in the DDS, as shown in Figure 1. Even with a very small mechanical force stimulus (nanonewtons) upon the cytotoxic T cell receptor activation by a homologous antigen, controllable drug release can be triggered to achieve more effective and precise treatment.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in mechanical force-responsive drug delivery systems

Liu

Lai

et al. 2022

Nanoscale Adv.

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“…[2][3][4][5] Such properties can be harnessed to generate enzyme-loaded polymersome nanoreactors which only perform catalysis when they are in an out-of-equilibrium state in response to stimuli. [6][7][8][9][10] One method that living systems have evolved to maintain these out-of-equilibrium processes is to control the transport of metabolites through chemically selective channels. In mimicking the activity of such stimuli-responsive channels within arti cial systems, small molecule photoswitches are especially attractive due to their ability to change geometry, polarity, and absorption pro les both in solution and in the solid-state.…”

Section: Introductionmentioning

confidence: 99%

Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors

Rifaie‐Graham

Yeow

Najer

et al. 2022

Preprint

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The circadian rhythm generates out-of-equilibrium metabolite oscillations controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes capable of light-gated chemical communication, controllable feedback and coupling to macroscopic oscillations. The populations consist of esterase-containing polymersomes functionalized with photo-responsive Donor-Acceptor Stenhouse Adducts (DASA) and light-insensitive semi-permeable urease-loaded polymersomes. The DASA-polymersome membrane becomes permeable under green light, switching on esterase activity and decreasing the pH, which in turn initiates production of alkali in the urease-containing population. A pH-sensitive pigment that absorbs green light when protonated provides a negative feedback loop for deactivating the DASA-polymersomes. Simultaneously, increased alkali production deprotonates the pigment, re-activating esterase activity by opening the membrane gate. We utilise light-mediated fluctuations of pH to perform non-equilibrium communication between the nanoreactors and use the feedback loops to induce work as chemomechanical swelling/deswelling oscillations in a crosslinked hydrogel. We envision possible applications in artificial organelles, protocells, and soft robotics.

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Shear Stress‐Responsive Polymersome Nanoreactors Inspired by the Marine Bioluminescence of Dinoflagellates

Abstract: Supporting information for this article is given via a link at the end of the document.

Cited by 32 publications

References 58 publications

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

Recent advances in mechanical force-responsive drug delivery systems

Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors

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