Shared neural mechanisms between imagined and perceived egocentric motion – A combined GVS and fMRI study

Macauda, Gianluca; Moisa, Marius; Mast, Fred W.; Ruff, Christian C.; Michels, Lars; Lenggenhager, Bigna

doi:10.1016/j.cortex.2019.04.004

Cited by 12 publications

(7 citation statements)

References 59 publications

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“…In contrast to our study, Macauda et al (2019) found activation in PIVC+ not only during galvanic vestibular stimulation but also during their SPT task. We did not find any task-specific activation in PIVC+.…”

Section: Discussioncontrasting

confidence: 99%

“…have shown that TMS over the right TPJ interferes with own-body mental imagery. Recently, Macauda et al (2019) provided the first evidence for a neural correlate of imagined selfrotation in PIVC+ by combining perceived self-rotations (induced by means of galvanic vestibular stimulation) with an SPT task in an fMRI paradigm. The task, which was adopted from Keehner et al (2006), involved an imagined self-rotation to adopt a different spatial perspective and a spatial judgment about a visual scene from this new perspective.…”

Section: Neural Correlates Of Own-body Mental Imagerymentioning

confidence: 99%

“…Based on previous neuroimaging studies using either own-body mental imagery or CVS, we predicted that structures in the IPL and SPL are prime candidates for integration of perceived and imagined self-rotation. We included PIVC+ as an additional ROI based on the recent findings of Macauda et al (2019). No fMRI study has yet identified neural correlates of a modulatory effect of CVS on own-body mental imagery.…”

Section: Hypothesismentioning

confidence: 99%

“…Previous research has shown that imagined selfrotations are modulated by concomitant vestibular information (Macauda et al, 2019;Deroualle, Borel, Devèze, & Lopez, 2015;Falconer & Mast, 2012;Lenggenhager, Lopez, & Blanke, 2008). Vestibular stimulation leads to impaired performance (Dilda, MacDougall, Curthoys, & Moore, 2012;Lenggenhager et al, 2008) but also to facilitation in imagined self-rotation (Falconer & Mast, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Vestibular Stimulation Modulates Neural Correlates of Own-body Mental Imagery

Klaus

Wyssen

Frank

et al. 2020

Journal of Cognitive Neuroscience

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There is growing evidence that vestibular information is not only involved in reflexive eye movements and the control of posture but it also plays an important role in higher order cognitive processes. Previous behavioral research has shown that concomitant vestibular stimuli influence performance in tasks that involve imagined self-rotations. These results suggest that imagined and perceived body rotations share common mechanisms. However, the nature and specificity of these effects remain largely unknown. Here, we investigated the neural mechanisms underlying this vestibulocognitive interaction. Participants ( n = 20) solved an imagined self-rotation task during caloric vestibular stimulation. We found robust main effects of caloric vestibular stimulation in the core region of the vestibular network, including the rolandic operculum and insula bilaterally, and of the cognitive task in parietal and frontal regions. Interestingly, we found an interaction of stimulation and task in the left inferior parietal lobe, suggesting that this region represents the modulation of imagined body rotations by vestibular input. This result provides evidence that the inferior parietal lobe plays a crucial role in the neural integration of mental and physical body rotation.

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Section: Discussioncontrasting

confidence: 99%

Section: Neural Correlates Of Own-body Mental Imagerymentioning

confidence: 99%

Section: Hypothesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vestibular Stimulation Modulates Neural Correlates of Own-body Mental Imagery

Klaus

Wyssen

Frank

et al. 2020

Journal of Cognitive Neuroscience

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“…The R-package brms [6], which is based on rstan [59] was used to calculate Bayesian ANOVAs and Bayesian multilevel models. Bayesian ANOVAs and multilevel models were calculated adopting the procedure described in Macauda and colleagues [31]. Bayesian procedures were used to provide posterior probability distributions for the estimated parameters, and non-informative priors were used for all parameters.…”

Section: Statistical Analysesmentioning

confidence: 99%

Real Bodies Not Required? Placebo Analgesia and Pain Perception in Immersive Virtual and Augmented Reality

Kempler²,

Lesur

et al. 2020

Preprint

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Pain represents an embodied process, wherein inferences are not only drawn from sensory inputs, but also from bodily states. Previous research has demonstrated that a placebo administered to an embodied rubber hand can effectively induce analgesia, providing first evidence that placebos can work even when applied to temporarily embodied, artificial body parts. Using a heat pain paradigm, the present study investigates placebo analgesia and pain perception during virtual embodiment. We examined whether a virtual placebo (a sham heat protective glove) can successfully induce analgesia, even when administered to a virtual body. The analgesic efficacy of the virtual placebo to the real hand (augmented reality setting) or virtual hand (virtual reality setting) was compared to a physical placebo administered to the own, physical body (physical reality setting). Furthermore, pain perception and subjective embodiment were compared between settings. Healthy participants (n=48) were assigned to either an analgesia-expectation or control-expectation group, where subjective and objective pain was measured at pre- and post-intervention time points. Results evinced that pre-intervention pain intensity was lower in the virtual reality setting, and that participants in the analgesia-expectation condition, after the intervention, exhibited significantly higher pain thresholds, and lower pain intensity and unpleasantness ratings than control-expectation participants, independent of the setting. Our findings evince that a virtual placebo can elicit placebo analgesia comparable to that of a physical placebo, and that administration of a placebo does not necessitate physical bodily interaction to produce analgesic responses, which might pave the way for effective new non-pharmacological approach for pain management.

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Stress and reward in the maternal brain of mothers with borderline personality disorder: a script-based fMRI study

Schneider

Herpertz

Ueltzhöffer

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Borderline personality disorder (BPD) is associated with altered neural activity in regions of salience and emotion regulation. An exaggerated sensitization to emotionally salient situations, increased experience of emotions, and dysfunctional regulative abilities could be reasons for increased distress also during parenting. Mothers with BPD tend to have less reciprocal mother–child interactions (MCI) and reveal altered cortisol and oxytocin reactivity in the interaction with their child, which could indicate altered processing of stress and reward. Here, we studied underlying neural mechanisms of disrupted MCI in BPD. Twenty-five mothers with BPD and 28 healthy mothers participated in a script-driven imagery functional magnetic resonance imaging (fMRI)-paradigm. Scripts described stressful or rewarding MCI with the own child, or situations in which the mother was alone. Mothers with BPD showed larger activities in the bilateral insula and anterior cingulate cortex (ACC) compared to healthy mothers during the imagination of MCI and non-MCI. Already in the precursory phase while listening to the scripts, a similar pattern emerged with stronger activity in the left anterior insula (AINS), but not in the ACC. This AINS activity correlated negatively with the quality of real-life MCI for mothers with BPD. Mothers with BPD reported lower affect and higher arousal. An exaggerated sensitization to different, emotionally salient situations together with dysfunctional emotion regulation abilities, as reflected by increased insula and ACC activity, might hinder sensitive maternal behavior in mothers with BPD. These results underline the importance for psychotherapeutic interventions to improve emotional hyperarousal and emotion regulation in patients with BPD, especially in affected mothers caring for young children.

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Shared neural mechanisms between imagined and perceived egocentric motion – A combined GVS and fMRI study

Cited by 12 publications

References 59 publications

Vestibular Stimulation Modulates Neural Correlates of Own-body Mental Imagery

Vestibular Stimulation Modulates Neural Correlates of Own-body Mental Imagery

Real Bodies Not Required? Placebo Analgesia and Pain Perception in Immersive Virtual and Augmented Reality

Stress and reward in the maternal brain of mothers with borderline personality disorder: a script-based fMRI study

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