Shared Gene Expression Between Multiple Sclerosis and Ischemic Stroke

Abstract

Patients with multiple sclerosis (MS) appear to have an increased risk of ischemic stroke (IS). Although MS and IS have very different phenotypes, gene-based and pathway-based analyses of large-scale genome-wide association studies (GWAS) have increasingly enhanced our understanding of these two diseases. Whether there are common molecular mechanisms connecting MS and IS is still unclear. Here, we describe the outcome of gene-based test and pathway-based analysis of GWAS datasets that explored potential gene expression links between MS and IS. After identifying significant gene sets individually of MS and IS, we performed pathway-based analysis in four biological pathway databases (KEGG, PANTHER, REACTOME, and WikiPathways) and GO categories. We discovered that there were 9 shared pathways between MS and IS in KEGG, 2 in PANTHER, 14 in REACTOME, 1 in WikiPathways, and 194 in GO annotations ( p < 0.05). These results provide an improved understanding about possible shared mechanisms and treatments strategies for MS and IS. They also provide some basis for further studies of how these two diseases are linked at the molecular level.

Platelet depletion does not alter long-term functional outcome after cerebral ischaemia in mice

“…The identity of these factors, whether they are actually secretion products or normally retained within platelets, and their effect if applied after infarct maturation, remain to be defined. Results obtained in dissimilar models such as EAE and ischaemic stroke are not overall comparable and need to be carefully reviewed, given that multiple sclerosis and stroke are fundamentally different disease entities that, however, share relevant molecular pathomechanisms involved in CNS damage ( Li et al, 2018 ).…”

Thinking Outside the Ischemia Box: Advancements in the Use of Multiple Sclerosis Drugs in Ischemic Stroke

“…Firstly, the genetic background of MS is indisputable [10,84,85]. Recent reports have claimed that MS and IS are also genetically linked [86], with numerous shared genes and similar gene expression levels [87]. One step further than genetics, epigenetics is also similarly altered in both of these entities.…”

Genetic and Expression Analysis of COPI Genes and Alzheimer’s Disease Susceptibility

“…VEGAS assigns SNPs to 17,787 autosomal genes according to the positions of SNPs and genes (± 50 kb from the 5′ and 3′ UTR) (Liu et al, 2010). Previous studies have provided more detailed information about the PLINK and VEGAS methods (Liu et al, 2013a; Liu et al, 2017d; Li et al, 2018; Lang et al, 2019).…”