Shared and unique mechanisms underlying binge eating disorder and addictive disorders

Schulte, Erica M.; Grilo, Carlos M.; Gearhardt, Ashley N.

doi:10.1016/j.cpr.2016.02.001

Cited by 211 publications

(184 citation statements)

References 286 publications

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“…Such findings are coupled with an exaggerated hypothalamic-pituitary-adrenal axis response and changes in anxiety, cognitive and social behaviors (Luczynski et al, 2016a). These brain (Becker et al, 1999;Lindvall Dahlgren and Wisting, 2016) Alcohol and substance use disorders ▪ Substance use disorders-cluster of cognitive, behavioral and physiological symptoms indicating that the individual continues using a substance despite significant substance-related problems (American Psychiatric Association, 2013) Alcohol and substance use disorders ▪ Underlying change in brain circuits that persist beyond detoxification; behavioral effects of these changes can be seen in relapse and craving (American Psychiatric Association, 2013) ▪ Symptoms include, but are not limited to craving, withdrawal, and tolerance ▪ Share similar neural correlates with Eating disorders with regard to altered reward signaling; involve issues with impulse control (Schulte et al, 2016) Substance use disorders ▪ 12-month prevalence and lifetime prevalence were 3.9% and 9.9%, respectively from 2012-2013 in the United States (Grant et al, 2016) ▪ Alcohol use disorders-medical diagnosis for severe problem drinking that consists of both physical and behavioral symptoms (American Psychiatric Association, 2013) Alcohol use disorders ▪ 12-month prevalence and lifetime prevalence were 13.9% and 29.1%, respectively (Grant et al, 2015) ▪ Harmful use of alcohol is leading cause of morbidity and mortality (Whiteford et al, 2013;Grant et al, 2015); accounts for approximately 2.5 million deaths per year worldwide (World Health Organization, 2011); fourth leading cause of disability worldwide (Whiteford et al, 2013) areas and behaviors are involved in ED and alcohol and substance use disorders pathology, thus it is plausible that the gut microbiota plays a role in such disorders. This systematic review examines the literature on, and discusses the relationship between, behaviors exhibited in these disorders and gut dysbiosis.…”

Section: Introductionmentioning

confidence: 99%

The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A ‘Ménage à Trois’?

Temko

Bouhlal

Farokhnia

et al. 2017

Alcohol and Alcoholism

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Aims: Accumulating evidence for the influence of the gut microbiota on the bidirectional communication along the gut-brain axis suggests a role of the gut microbiota in eating disorders (EDs) and alcohol and substance use disorders. The potential influence of altered gut microbiota (dysbiosis) on behaviors associated with such disorders may have implications for developing therapeutic interventions. Methods: A systematic review of preclinical and clinical studies evaluating the gut microbiota, EDs and alcohol and substance use disorders was conducted using MEDLINE, Embase and Web of Science databases with the objective being to examine the role of the gut microbiota in behavioral correlates of these disorders. Original papers focused on the gut microbiota and potential behavioral implications were deemed eligible for consideration. Results: The resulting 12 publications were limited to gut microbiota studies related to EDs and alcohol and substance use disorders. Some studies suggest that dysbiosis and gut microbial byproducts may influence the pathophysiology of EDs via direct and indirect interference with peptide hormone signaling. Additionally, dysbiosis was shown to be correlated with alcohol use disorder-related symptoms, i.e. craving, depression and anxiety. Finally, a mouse study suggests that manipulations in the gut microbiota may affect cocaine-related behaviors. Conclusions: Promising, albeit preliminary, findings suggest a potential role of the gut microbiota in behavioral correlates of EDs and alcohol and substance use disorders. Short summary: Preliminary evidence exists supporting the role of the gut microbiota in eating disorders and alcohol and substance use disorders, although additional investigation is needed to determine what is causative versus epiphenomenological.

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Section: Introductionmentioning

confidence: 99%

The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A ‘Ménage à Trois’?

Temko

Bouhlal

Farokhnia

et al. 2017

Alcohol and Alcoholism

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“…BED has a disorder of all mental dimensions concerning obesity: impulsivity, body image, mood and anxiety [7,36,37]. Impulsivity disorder is the most studied and researchers debate on the relation between BED and Impulse Control Disorders or the addictive disorders even if binge behavior is similar but not equal to craving [38][39][40]. In our sample, BED has the high prevalence (23,6%).…”

Section: Binge Eating Disorder: Bedmentioning

confidence: 91%

Obesity and Psychiatric Disorders in a Sample of Obese Candidates for Bariatric Surgery in Campania Region

Micanti¹,

Pecoraro²,

Mosca³

et al. 2017

Primary Health Care

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Introduction: Obesity is now considered as pandemic. 40% of Italian population is overweight or obese. Many studies emphasize the association of obesity with mental disorders specifically depressive and anxiety disorders, substance use disorder, personality disorder. It has to be distinguished from the mental dimensions: impulsivity, mood, anxiety and body image connected to the emotional regulation system producing eating behaviors. Obesity subjects differ in eating behaviors: gorging, snacking, sweeteating, grazing and binge that are characterised by different level of psychopathology. Mental disorders are also associated to eating behaviors. Bariatric surgery is considered gold standard therapy for obesity. However, follow-up studies underline that the association obesity-mental disorders determines weight loss failure.Methods: 2205 obese subjects underwent psychiatric assessment before bariatric surgery. Patients were divided into two groups as result of psychiatric assessment: 1392 obese subjects without association with mental disorders and 813 with mental disorders. These last (mean age 37,63 SD ± 12,07; 181 M, 632 W; mean body mass index (BMI), 45,16 SD ± 12,14) were enrolled in this study. Every patient underwent psychiatric evaluation. The absence of mental disorders was considered an exclusion criteria.

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“…The excess of dopamine causes strong, pleasant feeling which prompts to seek further stimuli that would increase or sustain the level of pleasure on the current level. On the other hand, reduced serotonin level may increase the reactivity on hedonistic feelings related to eating [15].…”

Section: Celmentioning

confidence: 99%

Binge eating disorder – etiopathogenesis, disease and treatment

Kucharska¹,

Kostecka²,

Tylec³

et al. 2017

ppn

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Purpose: The aim of this paper is to develop an updated evidence-based database of binge eating disorder (BED) to bring clinicians closer to their nosological position in the classification of mental illnesses and disorders, etiopathogenesis, progression, prognosis and treatment offer. Case description: Binge eating disorder is one of the most common eating disorders. The prevalence of BED in the general population is 2-5%, and among people with overweight or obesity -30%. In the American Psychiatric Classification of DSM-5, a violent binge eating disorder is a separate disease, while the European ICD-10 classification is confused with: overeating related to other psychological factors. In the development of BED, apart from socio-cultural factors, biological, behavioral, cognitive, psychological, personality, temperamental, family and environmental factors are important. There is an increase in the incidence of eating disorders, including the BED, especially in those countries where the cult of lean body is present, the pace of life, the demands and the pressure of the environment are increasing. Gassing attacks are an attempt at relieving the increasing tension and point to the presence of emotional control disorder, leading to the development of self-destructive behaviors. Comment: Prognosis for the people with BED is better than for other eating disorders. 50-80% of patients undergoing remission are affected. Psychotherapy or the combined treatment of psychotherapy with pharmacotherapy have better therapeutic effects compared to the use of only biological therapy. The authors of the study illustrate the course and treatment of the discussed disorder by an example of a characteristic clinical case. Key words: eating disorders, binge eating disorder, clinical. StreszczenieCel: W pracy przedstawiono zaktualizowane dane oparte na dowodach (evidence based) dotyczące zespołu kompulsyjnego objadania się (binge eating disorder -BED) w celu przybliżenia klinicystom jego pozycji nozologicznej w obowiązujących klasyfikacjach chorób i zaburzeń psychicznych, etiopatogenezy, przebiegu, rokowania i możliwości terapeutycznych. Opis przypadku: Zespół kompulsyjnego objadania się należy do najczęściej występujących zaburzeń odżywiania się. Rozpowszechnienie BED w populacji ogólnej wynosi 2-5%, a wśród osób z nadwagą bądź otyłością -30%. W amerykańskiej klasyfikacji

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Shared and unique mechanisms underlying binge eating disorder and addictive disorders

Cited by 211 publications

References 286 publications

The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A ‘Ménage à Trois’?

The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A ‘Ménage à Trois’?

Obesity and Psychiatric Disorders in a Sample of Obese Candidates for Bariatric Surgery in Campania Region

Binge eating disorder – etiopathogenesis, disease and treatment

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