Shall we use cryotherapy in the treatment in surgical procedures, in acute pain or injury, or in long term pain or dysfunction? - A systematic review

Klintberg, Ingrid Hultenheim; Larsson, Maria

doi:10.1016/j.jbmt.2021.03.002

Cited by 7 publications

(5 citation statements)

References 72 publications

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“…An important aspect of cryotherapy is its high tolerability. While good tolerance of cryotherapy has been consistently seen in case of many conditions, our study is the first to show it in CFS, with all included participants completing the study [41]. This is in contrast to some other approaches, for example, an aerobic activity programme, from which the dropout rate was about 50% [42,43].…”

Section: Influence Of Wbc On Cognitive Functionmentioning

confidence: 71%

Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome

et al. 2022

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Background The aim of this study was to explore the tolerability and effect of static stretching (SS) and whole body cryotherapy (WBC) upon fatigue, daytime sleepiness, cognitive functioning and objective and subjective autonomic nervous system functioning in those with Chronic Fatigue Syndrome (CFS) compared to a control population. Methods Thirty-two CFS and eighteen healthy controls (HC) participated in 2 weeks of a SS + WBC programme. This programme was composed of five sessions per week, 10 sessions in total. Results A significant decrease in fatigue was noted in the CFS group in response to SS + WBC. Some domains of cognitive functioning (speed of processing visual information and set-shifting) also improved in response to SS + WBC in both CFS and HC groups. Our study has confirmed that WBC is well tolerated by those with CFS and leads to symptomatic improvements associated with changes in cardiovascular and autonomic function. Conclusions Given the preliminary data showing the beneficial effect of cryotherapy, its relative ease of application, good tolerability, and proven safety, therapy with cold exposure appears to be an approach worth attention. Further studies of cryotherapy as a potential treatment in CFS is important in the light of the lack of effective therapeutic options for these common and often disabling symptoms.

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Section: Influence Of Wbc On Cognitive Functionmentioning

confidence: 71%

Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome

et al. 2022

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“…Prostaglandin E2 (PGE2) concentration, known as a mediator responsible for sensitisation to central and peripheral pain, has been also found to be reduced when ultra-low temperatures are applied (58,59). In the case of the anti-inflammatory effect, a in vivo 38: 1-39 (2024) hypermetabolic state within the treated tissue was recorded as well as compromised circulation of the blood (60). PGE2 which is also a marker of inflammation has been found to decrease in concentration during cryotherapy, indicating a positive anti-inflammatory effect.…”

Section: Cryotherapymentioning

confidence: 98%

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

MOKBEL,

KODRESKO,

GHAZAL

et al. 2023

In Vivo

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This paper explores the crucial role of cryogenic mediums in driving breakthroughs within the biomedical sector. The objective was to investigate, critically discuss, and present the current knowledge and state-of-the-art practices, along with the challenges and perspectives of the most common applications. Through an extensive literature review, this work aims to supplement existing research, offering a comprehensive and up-to-date understanding of the subject. Biomedical research involving cryogenic mediums is advancing on multiple fronts, including the development of advanced medical technologies, clinical treatments for life-threatening conditions, high-quality biospecimen preservation, and antimicrobial interventions in industrial food processing. These advances open new horizons and present cutting-edge opportunities for research and the medical community. While the current body of evidence showcases the impressive impact of cryogenic mediums, such as nitrogen, helium, argon, and oxygen, on

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“…While thermal therapies demonstrate short-term analgesia, long-term effectiveness and optimal protocols require further research through high-quality, large-scale randomized controlled trials with extended follow-up periods [ 94 ]. There is a lack of evidence on the duration of pain relief and ideal treatment frequency and dosing [ 92 ].…”

Section: Types Of Ninptmentioning

confidence: 99%

“…Heat therapy risks include dehydration and aggravated inflammation if overheated [ 96 ]. Prolonged exposure to extreme cold may cause irreversible nerve injury [ 94 ]. Application guidelines regarding duration, temperature thresholds, and monitoring should be followed, especially in special populations.…”

Section: Types Of Ninptmentioning

confidence: 99%

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Shi,

2023

BMC Med

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Background Chronic pain conditions impose significant burdens worldwide. Pharmacological treatments like opioids have limitations. Non-invasive non-pharmacological therapies (NINPT) encompass diverse interventions including physical, psychological, complementary and alternative approaches, and other innovative techniques that provide analgesic options for chronic pain without medications. Main body This review elucidates the mechanisms of major NINPT modalities and synthesizes evidence for their clinical potential across chronic pain populations. NINPT leverages peripheral, spinal, and supraspinal mechanisms to restore normal pain processing and limit central sensitization. However, heterogeneity in treatment protocols and individual responses warrants optimization through precision medicine approaches. Conclusion Future adoption of NINPT requires addressing limitations in standardization and accessibility as well as synergistic combination with emerging therapies. Overall, this review highlights the promise of NINPT as a valuable complementary option ready for integration into contemporary pain medicine paradigms to improve patient care and outcomes.

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Shall we use cryotherapy in the treatment in surgical procedures, in acute pain or injury, or in long term pain or dysfunction? - A systematic review

Cited by 7 publications

References 72 publications

Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome

Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

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