Sezary's Syndrome: A Case Report Including Ultrastructural and Immunohisto‐chemical Characterization of the Cellular Infiltrates

Abstract

A case of a 77-year-old male with Sezary's syndrome (55) is reported, including ultrastructural and immunohistochemical characterization of the cellular infiltrates.Atypical lymphocytes in the skin were evaluated at stages of both clinical exacerbation and improvement. During both stages, skin specimens revealed essentially similar findings. They were diffusely infiltrated by atypical lymphocytes with a characteristic nuclear convolution. The infiltrating cells exhibited T-cell markers which cross-reacted with the T -cells of the lymph nodes. Atypical convoluted cells in the peripheral blood were PA5 positive and peroxidase negative. The morphological and functional characteristics of the cellular infiltrates in 55 and its clinical independence from mycosisfungoides were discussed.