Sexual steroids in urogynecology

Sartori, Marair Grácio Ferreira; Feldner, Paulo Cezar; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Castro, Rodrigo Aquino; Baracat, Edmund Chada; Lima, Geraldo Rodrigues de; Girão, M. J. B. C.

doi:10.3109/13697137.2010.508542

Cited by 20 publications

(11 citation statements)

References 55 publications

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“…It is notable that despite the well-known fact that sex hormones, e,g., estrogen and progesterone are expressed in the urothelium and are important for its function (Sartori et al, 2011), studies on how such hormones influence ATP release do not seem to be available. This may be a fruitful area for further studies.…”

Section: Urothelial Atp Releasementioning

confidence: 98%

Purinergic signalling in the urinary bladder

Andersson¹

2015

Autonomic Neuroscience

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Section: Urothelial Atp Releasementioning

confidence: 98%

Purinergic signalling in the urinary bladder

Andersson¹

2015

Autonomic Neuroscience

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“…Pelvic and perineal skeletal muscles play important roles in the physiology of the lower urogenital tract in where they accomplish particular reproductive and excretory functions . Morphometric and functional alterations in these muscles are related to the onset of gynaecological and urinary dysfunctions in women, some of them modelled in experimental animals . The variation in the expression of estrogen receptors (ER) in the lower urogenital tract has been associated with some pelvic dysfunctions .…”

Section: Introductionmentioning

confidence: 99%

Aromatase expression is linked to estrogenic sensitivity of periurethral muscles in female rabbits

Carrasco-Ruiz

García-Villamar

López-García

et al. 2015

Cell Biochemistry & Function

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Beyond its role in the conversion of androgens to estrogens, the expression of aromatase could influence on the estrogenic signalling in targeted tissues. Considering the well-defined biochemical and physiological differences between the pubococcygeus (Pcm) and bulbospongiosus (Bsm) muscles in female rabbits, it is presently hypothesized that the aromatase expression is differentially linked to the estrogen sensitivity of each muscle. To this end, serum estradiol levels and the aromatase expression, presence of ERα and ERβ and morphometry were evaluated in the Pcm and Bsm of female rabbits allocated in control, ovariectomized (OVX) and OVX treated with estradiol benzoate (OVX + EB) groups. Aromatase expression was high in the Pcm. Independently to serum estradiol, ovariectomy increased aromatase expression in the Pcm while decreased it in the Bsm. The EB treatment avoided the effect of ovariectomy only in the Pcm. The number of immunoreactive nuclei anti-ERα and anti-ERβ was high in the Pcm of OVX and OVX + EB rabbits, while those in the Bsm remained unchanged. The number of peripheral nuclei per fibre and the cross-sectional area-to-myonucleus ratio were modified only in the Pcm. Our findings support aromatase expression in the Pcm, and Bsm of rabbits is differentially linked to estrogenic sensitivity of each muscle.

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“…8,9 In female aging, effects in lower genital tract are common and related to late post-menopause, being atrophic vulvovaginitis and urogenital dysfunctions common complaints brought by patients. 15,16 Atrophic vulvovaginitis affects 40% of postmenopausal women. Effects of prolonged hypoestrogenism are observed on physical examination of the vulva and vagina and clinical findings include loss of vaginal rugae, reduced elasticity, sparse vaginal content and thinning of the vaginal mucosa.…”

mentioning

confidence: 99%

“…Effects of prolonged hypoestrogenism are observed on physical examination of the vulva and vagina and clinical findings include loss of vaginal rugae, reduced elasticity, sparse vaginal content and thinning of the vaginal mucosa. 15 All these aspects influence the daily lives of patients on account of clinical manifestations, such as symptoms of vaginal dryness, pain or discomfort during intercourse, and urinary symptoms such as dysuria and urgency. 14,16 Genitourinary dysfunction, in turn, characterized by sagging, dystopia and incontinence, may be made worse with the decrease in collagen secondary to hypoestrogenism affecting the support mechanisms, fasciae, and ligaments of the pelvic floor.…”

mentioning

confidence: 99%

Female aging

Sorpreso

Júnior²,

Fonseca³

et al. 2015

Rev. Assoc. Med. Bras.

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Conflict of interest: noneFemale aging is a process that involves hypoestrogenism time, the individual impact on each woman, and what we can do as experts to reduce morbidity and provide quality of life. This natural process in the female life cycle has been of concern to women after menopause. Changes in different biophysical and psychosocial aspects, and their individual experiences, have repercussions on the lives of patients seeking specialized and multidisciplinary support to reduce the harmful effects of prolonged hypoestrogenism. Overweight and obesity, inadequate living habits and the presence of multi-morbidities cause damage to the quality of life and impact the functional capacity. Behavioral prescription and hormone therapy are among the treatments given to ease symptoms and reduce morbidity. A better understanding of these factors can help identify groups that require more care after menopause.Keywords: post-menopause, women, aging.Aging is a physiological process in life and, in women, it is influenced by hypoestrogenism the greater their longevity. The increase in life expectancy among women brought changes in the mortality panorama. 1 Currently, the prevalence of chronic diseases, malignancies and repercussions of hypoestrogenism in each individual serves as motivation for health professionals in clinical and gynecological settings to offer prevention and promotion actions for women seeking quality of life and reduced morbidity. 2,3Also, concern about the quality of life and prevention of chronic diseases and cancer are the demands of women seeking a gynecologist.3,4 The notion of health has been a concern of the very patients interested in weight maintenance, adoption of healthy lifestyle habits, cessation of legal and illegal adictions, and the use of medications for adequate control of chronic diseases. 5Changes in biophysical aspects also affect the quality of life caused by prolonged hypoestrogenism related to urogenital disorders, changes in sexual behavior and libido, memory, skin tropism, effects on lipid profile, and bone metabolism. Psychosocial factors contribute to a positive or negative perception of women's health, which depends on how she experiences and sees life after menopause.7 There are occurrences such as loss of loved ones, change in marital status, retirement process, and prior preparation of this phase in which women turn their attention to themselves, their achievements and accomplishments, their wishes and needs. 8 It is known that age, overweight and obesity, smoking, and the presence of multi-morbidities impair the quality of life and impact the functional capacity.9 According to Fonseca et al., the most relevant information in medical history declared at the time of the initial treatment in women after menopause were: hypertension (44.94%), diabetes (10.1%), smoking (8.39%), thyroid disorders (7.7%), malignancies (6.41%), cardiovascular disease (17.1%), dyslipidemia (0.88%) and psychiatric disorders (0.06%).

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Sexual steroids in urogynecology

Cited by 20 publications

References 55 publications

Purinergic signalling in the urinary bladder

Purinergic signalling in the urinary bladder

Aromatase expression is linked to estrogenic sensitivity of periurethral muscles in female rabbits

Female aging

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