Sexual and vertical transmission of visceral leishmaniasis

Turchetti, A; Souza, Tamara Daiane de; Paixão, Tatiane Alves da; Santos, Renato L.

doi:10.3855/jidc.4108

Cited by 32 publications

(21 citation statements)

References 41 publications

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“…Diniz et al [15] emphasized the importance of animal reservoirs in facilitating transmission of VL in densely populated urban areas in Brazil, and recently, Turchetti et al [16] discussed the role of sexual and vertical transmission of this disease in canine populations playing an important role in the maintenance of VL.…”

Section: Introductionmentioning

confidence: 99%

Recent updates and perspectives on leishmaniasis

Savoia

2015

J Infect Dev Ctries

141

127

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Leishmaniasis is a neglected vector-borne tropical infection considered to be a disease of the poor. Concentrated in poverty-stricken countries within Southeast Asia, East Africa, and Latin America, it is also endemic in several Mediterranean countries. The management of the heterogeneous syndromes determined by parasites belonging to the genus Leishmania is particularly difficult in developed, non-endemic countries owing to the unfamiliarity of physicians with clinical symptoms, diagnostic possibilities, and available treatment options. Therefore, travelers and other people who may be exposed to sand flies in endemic areas should receive counseling regarding leishmaniasis and appropriate protective measures. Serological diagnosis is rarely used for cutaneous and mucocutaneous diseases, but it is the most commonly used technique for visceral leishmaniasis. The drugs used to treat this last disease are expensive and sometimes have toxic side effects. This review highlights the diagnostic, chemotherapeutic, and immunizing strategies to control leishmaniasis, though no human vaccine is commercially available currently owing to the complexity of the cellular immune response to this parasite.

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Section: Introductionmentioning

confidence: 99%

Recent updates and perspectives on leishmaniasis

Savoia

2015

J Infect Dev Ctries

141

127

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“…This type of transmission is called vertical transmission. Now it is found that vector-borne diseases can also be transmitted vertically [3,4]. Also new research shows that virus is transmitted from female mosquitos to their eggs at a high rate [5], which causes vertical transmission of the disease.…”

Section: Introductionmentioning

confidence: 99%

New mathematical model of vertical transmission and cure of vector-borne diseases and its numerical simulation

2018

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In this research article, a new mathematical model for the transmission dynamics of vector-borne diseases with vertical transmission and cure is developed. The non-negative solutions of the model are shown. To understand the dynamical behavior of the epidemic model, the theory of basic reproduction number is used. As this number increases, the disease invades the population and vice versa. The effect of vertical transmission and cure rate on the basic reproduction number is shown. The disease-free and endemic equilibria of the model are found and both their local and global stabilities are presented. Finally, numerical simulations are carried out graphically to show the dynamical behaviors. These results show that vertical transmission and cure have a valuable effect on the transmission dynamics of the disease.

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“…Other forms of transmission have already been reported, such as vertical and/or sexual transmission [11], non-vector hematogenous [12,13], and through other vectors, such as Rhipicephalus sanguineus [14], but their role in the maintenance of the disease is not totally clear yet.…”

Section: Introductionmentioning

confidence: 99%

Alternative Treatment for Leishmaniasis

Oliveira¹,

Melo²,

Penha-Silva³

et al. 2018

Leishmaniases as Re-Emerging Diseases

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Leishmaniasis remains as one of the most important neglected diseases in the world and, after all these years, its treatment is still a problem, mainly because of the side effects caused by the first-and second-line drugs and the indiscriminate treatment, which leads to increasing cases of parasite resistance. The search for alternative therapies for the treatment of leishmaniasis is extremely important. In this context, the use of natural products arises as a promising alternative, combining the empirical knowledge disseminated in the population with researches that aim to scientifically prove the therapeutic effects of plants. Based on this, the use of medicinal plants is considered a desirable and accessible tool in the treatment of these diseases and considered by pharmacognosy as a valuable source for the development of new drugs and as adjuvant for conventional therapies.

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Sexual and vertical transmission of visceral leishmaniasis

Cited by 32 publications

References 41 publications

Recent updates and perspectives on leishmaniasis

Recent updates and perspectives on leishmaniasis

New mathematical model of vertical transmission and cure of vector-borne diseases and its numerical simulation

Alternative Treatment for Leishmaniasis

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