Sex steroid axes in determining male predominance in hepatocellular carcinoma

Zhang, Lei; Wu, Jinfeng; Wu, Qiong; Zhang, Xiang‐juan; Lin, ShuaiCai; Ran, WanLi; Zhu, Ling; Tang, ChengYan; Wang, Xing

doi:10.1016/j.canlet.2022.216037

Cited by 10 publications

(7 citation statements)

References 84 publications

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“…Its occurrence is a long‐term, dynamic, multistage, multigene change process, and the incidence of HCC is increasing yearly (Hartke et al, 2017), but the current pathogenesis is still unclear. In recent years, the relationship between steroid hormone imbalance and HCC has been studied deeply (Hassan et al, 2021; Patil et al, 2022; Zhang et al, 2023). Cortisol, the most important glucocorticoid secreted by the cortical band of the adrenal cortex, can enhance the body’s stress function (Oswald et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

LC–MS/MS method for the quantification of cortisol of hepatocellular carcinoma

Zhou,

Li,

Yin

et al. 2024

Biomedical Chromatography

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The imbalance of steroid hormones is closely related to the occurrence and development of hepatocellular carcinoma (HCC). However, most research has focused on steroid hormone receptors, and reports about the relationship between the serum concentration of cortisol and the development of HCC are rare. The aim of this research was to establish a simple, specific, sensitive and reliable liquid chromatography–mass spectrometry/mass spectrometry (LC–MS/MS) method for the quantitation of cortisol in human serum and to compare the level of cortisol in serum between 221 HCC patients and 183 healthy volunteers. The results showed that the correlation coefficients of the linear regression with a weighing factor of 1/x2 ranged from 0.9933 to 0.9984 over the range of 2–1,000 ng/ml. The inter‐ and intra‐day precision and accuracy were <10%. The matrix effect and recovery of cortisol were 94.9–102.5% and 96.3–99.8%, respectively. The concentration of cortisol in HCC patients was significantly higher than that in healthy volunteers (p < 0.05) and was not affected by sex, age, menopause or α‐fetoprotein (AFP) level. The present study reveals that elevated cortisol might promote the progression of HCC.

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Section: Resultsmentioning

confidence: 99%

LC–MS/MS method for the quantification of cortisol of hepatocellular carcinoma

Zhou,

Li,

Yin

et al. 2024

Biomedical Chromatography

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“…Much research over the last 20 years provides the concept that androgen is pro-carcinogenic by accelerating cell proliferation via androgen receptor signaling, whereas estrogen is tumor suppressive by inducing cell apoptosis and immune responses. 43 Of note, a novel estrogen-related gene prognostic signature was recently discovered to predict patient survival and immunotherapy response of HCC patients. 44 Overall, these markers have provided diagnostic and prognosis potential and suggest that genetic and/or hormonal mechanisms could explain male predominance in HCC.…”

Section: Discussionmentioning

confidence: 99%

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice

Golonka,

Yeoh,

Saha

et al. 2024

Cellular and Molecular Gastroenterology and Hepatology

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“…Therefore, there is a huge space for research in the future. Studies have summarized that the estrogen-ERα axis plays a tumor-suppressing role in the malignant -transformation stage of HCC, which induces apoptosis of hepatocytes and inhibiting proliferation of carcinogenic cells, 110,189 but opposite effects of ERα in the metastasis stage has been noticed, one possible explanation is that largely expression of vERα in development process of HCC may promote tumor development. 114,115 ERα36/EGFR maintains HCC steam cell characteristics has been reported, but other mechanism of vERα in HCC development and related signal transduction still needs further research.…”

Section: Discussionmentioning

confidence: 99%

The role of sex hormones and receptors in HBV infection and development of HBV‐related HCC

Nuermaimaiti,

Chang,

Yan

et al. 2023

Journal of Medical Virology

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Gender disparity in hepatitis B virus (HBV)‐related diseases has been extensively documented. Epidemiological studies consistently reported that males have a higher prevalence of HBV infection and incidence of hepatocellular carcinoma (HCC). Further investigations have revealed that sex hormone‐related signal transductions play a significant role in gender disparity. Sex hormone axes showed significantly different responses to virus entry and replication. The sex hormones axes change the HBV‐specific immune responses and antitumor immunity. Additionally, Sex hormone axes showed different effects on the development of HBV‐related disease. But the role of sex hormones remains controversial, and researchers have not reached a consensus on the role of sex hormones and the use of hormone therapies in HCC treatment. In this review, we aim to summarize the experimental findings on sex hormones and provide a comprehensive understanding of their roles in the development of HCC and their implications for hormone‐related HCC treatment.

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Sex steroid axes in determining male predominance in hepatocellular carcinoma

Cited by 10 publications

References 84 publications

LC–MS/MS method for the quantification of cortisol of hepatocellular carcinoma

LC–MS/MS method for the quantification of cortisol of hepatocellular carcinoma

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice

The role of sex hormones and receptors in HBV infection and development of HBV‐related HCC

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