volume 8, issue 4, P697-708 2016
DOI: 10.18632/aging.100920
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Anna Kovalchuk, Rocio Rodriguez-Juarez, Yaroslav Ilnytskyy, Boseon Byeon, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Bryan Kolb, Olga Kovalchuk

Abstract: Recent research shows that chemotherapy agents can be more toxic to healthy brain cells than to the target cancer cells. They cause a range of side effects, including memory loss and cognitive dysfunction that can persist long after the completion of treatment. This condition is known as chemo brain. The molecular and cellular mechanisms of chemo brain remain obscure. Here, we analyzed the effects of two cytotoxic chemotherapy drugs—cyclophosphamide (CPP) and mitomycin C (MMC) - on transcriptomic and epigeneti…

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